2016 American Transplant Congress
Calcineurin Inhibitor (CNI) Delay with ATG Induction: Teaching an Old Dog, New Tricks.
CNI delay early after heart transplantation is a recommended therapeutic option according to ISHLT guidelines. However, there exist only few published data on feasibility of…2016 American Transplant Congress
IVIG and High Dose Steroid Treatment of Transplant Glomerulopathy Effectively Slows Progression of Loss of Renal Allograft Function.
Introduction Transplant glomerulopathy (TG) is commonly associated with chronic antibody mediated rejection and is a major cause of late kidney allograft loss with no established…2016 American Transplant Congress
Contrasting Effects of Tacrolimus and Everolimus on Regulatory T Cell Activation and Mixed Hematopoietic Chimerism Induced by Natural Killer T Cell Stimulation.
Calcineurin (CN)-dependent IL-2 production is crucial for regulatory T cells (Tregs) to demonstrate suppressive activity. The mTOR signal is not required for Treg function because…2016 American Transplant Congress
Pre-Transplant Risk Factors: Predicting Nonadherence and Rejection in Adult Liver Transplant Recipients.
Purpose: The pre-liver transplant (LT) psychosocial evaluation aims to identify risk factors for immunosuppression nonadherence (NA) and poor post-LT outcomes. Despite broad support for these…2016 American Transplant Congress
Therapeutically Equivalent Results to Caucasians in Black Kidney Transplant Recipients Using ASTAGRAF XL® Despite a Higher Degree of HLA Mismatch : A Post-Hoc Analysis of Phase III Data from Over 2000 Patients.
Astelleas Pharma Global Develepment, Northbrook, IL.
INTRO: When contemplating the use of a new immunosuppressant agent in kidney transplantation, measuring outcomes in potentially vulnerable populations is of paramount concern. As such,…2016 American Transplant Congress
Does Post-Transplant Adherence Come at a Cost?
University of Minnesota, Minneapolis, MN.
Background: It is well documented that organ transplant (tx)recipients have an increased incidence of cancer including virus associated cancers like lymphoma. Our objective was to…2016 American Transplant Congress
Mycophenolic Acid Product Discontinuation Prior to Conception: Analysis of Pregnancies in Kidney Transplant Recipients.
Mycophenolic acid (MPA) products are considered teratogenic and transplant centers report discontinuing MPA in female kidney recipients anticipating pregnancy. Data were collected by the National…2016 American Transplant Congress
Avoidance of CNI and Steroids Using Belatacept – A Preliminary Report of CTOT-16.
1UAB, Birmingham; 2UCSF, San Francisco; 3Emory, Atlanta; 4Rho, Chapel Hill; 5NIAID, Bethesda.
CTOT-16 tested the hypothesis that belatacept used as maintenance immunosuppression (IS) in kidney transplantation would allow the long-term avoidance of CNI and corticosteroids. Methods: Primary…2016 American Transplant Congress
Alloantibody Suppression by Bruton Tyrosine Kinase Antagonist Ibrutinib Is Associated with a Moderate Splenic B-Cell Reduction.
Comprehensive Transplantation Center/Surgery, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Bruton tyrosine kinase (Btk) is specifically required for activation of the B-cell antigen receptor signaling pathway that contributes to the initiation and maintenance of…2016 American Transplant Congress
Predicting Late Medication Non-Adherence in Adult Kidney Transplant Recipients.
Background: Medication non-adherence (MNA) is a significant contributor to late graft loss in kidney transplant recipients. The aim of this study was to develop and…
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