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Articles tagged "Immunosuppression"

  • 2016 American Transplant Congress

    Excellent Results of Living-Related Renal Transplant Recipients Treated with High-Dose Mizoribine – Comparison of Taclorimus with CsA for Two Years Result by a Japanese Multicenter Study.

    N. Yoshimura, K. Nishimura, K. Akioka, M. Shimazu, K. Nose, T. Nishioka, N. Nakamura, K. Uchida, T. Nakatani, H. Ushigome.

    Japanese Multicenter Study Group of High Dose Mizoribine in Kidney Transplantation, Kyoto, Japan.

    (Aims) Mizoribine (MZR) has been developed as an immunosuppressive agent, but has a less potent immunosuppressive effect up to 3 mg/kg/day. The widespread use of…
  • 2016 American Transplant Congress

    Long-Term Outcomes in Pediatric Live-Donor Liver Transplantation.

    N. Celik,1 A. Ganoza,2 F. Vyas,1 J. Squires,3 V. Venkat,3 G. Bond,1 K. Soltys,1 R. Sindhi,1 R. Squires,3 A. Humar,2 G. Mazariegos.1

    1Hillman Center for Pediatric Transplantation, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA; 2Thomas E. Starzl Transplantation Institute, Department of Surgery at UPMC, Pittsburgh, PA; 3Division of Pediatric Gastroenterology, CHP of UPMC, Pittsburgh, PA.

    Aim: To determine the incidence of allograft and medical factors characterizing optimal patient outcomes 3 year or more after pediatric live-donor liver transplantation (LDLT). Methods:…
  • 2016 American Transplant Congress

    Targeting the Constitutively Active PI3K/Akt/mTOR Signaling Pathway in Epstein-Barr Virus B Cell Lymphomas.

    A. Sang, G. Ivison, C. Esquivel, S. Krams, O. Martinez.

    Division of Abdominal Transplantation, Stanford School of Medicine, Stanford, CA.

    Epstein-Barr virus (EBV) B cell lymphomas in post-transplant lymphoproliferative disorder (PTLD) is a major problem in organ transplantation. Reduction of immunosuppression sometimes result in tumor…
  • 2016 American Transplant Congress

    Rapamycin Encapsulated Nanoparticles as Pre-Treatment in Lung Transplantation.

    G. Bazzle,1 S. Dixit,2 K. Patel,3 A.-M. Broome,2 S. Nadig,1,3 C. Atkinson.1,3

    1Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; 2Department of Radiology, Medical University of South Carolina, Charleston, SC; 3Department of Surgery, Medical University of South Carolina, Charleston, SC.

    Introduction: While short-term lung transplant outcomes have improved over the years, long-term survival rates remain stagnant. Many injuries occur to the donor organ before transplantation,…
  • 2016 American Transplant Congress

    Everolimus (EVR) versus Mycophenolate Sodium (MPS) for Recipients of Kidney Transplants from Expanded Criteria Donors (ECD) Receiving Anti-Thymocyte Globulin (r-ATG) and Tacrolimus (TAC).

    H. Tedesco-Silva,1 C. Felipe,1 A. Brigido,1 A. Bessa,1 M. Paula,1 P. Ruppel,1 M. Cristelli,1 L. Viana,1 G. Basso,1 M. Franco,2 W. Aguiar,1 J. Medina-Pestana.1

    1Nephrology Division, Hospital do Rim - UNIFESP, Sao Paulo, Brazil; 2Pathology Division, UNIFESP, Sao Paulo, Brazil.

    Introduction: There is no standard of care immunosuppressive regimen for recipients of kidneys recovered from expanded criteria donors. Several centers use r-ATG induction due to…
  • 2016 American Transplant Congress

    The Optimal Time Point for Steroid Withdrawal After Kidney Transplantation Is One Year After Engraftment.

    M. Haller,1 M. Kammer,1,2 A. Kainz,2 G. Heinze,1 R. Oberbauer.1,2

    1Center for Medical Statistics, Informatics and Intelligent Systems (CeMSIIS), Medical University of Vienna, Vienna, Austria; 2Department of Medicine, Medical University of Vienna, Vienna, Austria.

    The optimal time of steroid withdrawal after kidney transplantation remains elusive, since RCTs can evaluate one predefined time point. Thus we analyzed all first kidney…
  • 2016 American Transplant Congress

    Absence of Acute Allograft Rejection in the Early Post Operative Period in a Full Face VCA Recipient with a Positive B-Cell Flow Cytometric Crossmatch Utilizing an Induction Immunosuppression Regimen Including Anti-thymocyte and Anti-CD20 Agents.

    B. Gelb,3 M. Plana,1 D. Dadhania,2 M. Suthanthiran,2 J. Diaz-Siso,1 E. Rogriguez.1

    1Plastic and Reconstructive Surgery, NYU Langone, New York; 2Rogosin Institute, New York; 3Transplant Surgery, NYU Langone, New York.

    Background: The presence of donor-specific antibodies (DSA) to human leukocyte antigen (HLA) convey increased risk of allograft rejection. Patients suffering full-thickness burns to the face…
  • 2016 American Transplant Congress

    Th17 Development Is Critical for Airway Epithelial Injury After Transplantation.

    J. Xu, Y. Zhang, L. Wang, X. Li, R. Chen, R. Zhang, Y. Ding.

    Department of Immunology, Capital Medical University, Beijing, China.

    Background: Development of obliterative bronchiolitis (OB) is the biggest obstacle that limits long-term allograft survival and clinical application of lung transplantation, and the precise mechanisms…
  • 2016 American Transplant Congress

    Advantages of Computerized Dosing Strategy in Tacrolimus Treatment of Renal Transplant Patients.

    S.-Y. Kim,1 S. Cho,1 M.-J. Cho,1 C. Lee,1 A. Han,1 C. Choi,1 S. Ahn,1 S.-I. Min,1 S.-K. Min,1 M. Park,2 I. Jung,3 S. Kim,4 J. Ha.1,2

    1Department of Surgery, Seoul National University Hospital, Seoul, Korea; 2Korea Organ Donation Agency, Seoul, Korea; 3Department of surgery, Seoul Metropolitan Government - Seoul National University Boramae Medical Center, Seoul, Korea; 4Department of Surgery, Myoungji Hospital, Goyang-si, Korea.

    Purpose: Tacrolimus (Tac) is widely used in immunosuppression for kidney transplant (KT) patients. Despite this, it is still difficult for expert physicians to achieve and…
  • 2016 American Transplant Congress

    Factors Predicting Tacrolimus Trough Variability After Lung Transplantation.

    K. Boyle, M. Moranville, P. Shah.

    The Johns Hopkins Hospital, Baltimore, MD.

    Background: Recent data suggests that variability in tacrolimus trough concentrations is associated with acute and chronic rejection. The purpose of this study was to identify…
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