ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunosuppression"

  • 2022 American Transplant Congress

    Pegloticase Use in Renal Transplant Recipients with Gout: Findings from an Insurance Claims Database Study

    C. A. Shadur1, B. Marder2, C. Vesel2, B. LaMoreaux2

    1Iowa Kidney Physicians, Des Moines, IA, 2Horizon Therapeutics plc, Deerfield, IL

    *Purpose: Kidney transplant (KT) recipients have high gout incidence due to reduced eGFR and medication use associated with hyperuricemia.1 Oral urate-lowering therapies in KT patients…
  • 2022 American Transplant Congress

    Comparing The Immunologic Responses Between Kidney Transplant Recipients Receiving Standard Immunosuppression And CNI Reduction After Two Doses Of ChAdOx-1 And A Booster Dose BNT162b2

    S. Phirom1, T. Kitrungphaiboon2, W. Jantarabenjakul2, Y. Avihingsanon2, W. Prasithsirikul3, J. Vanichanan4, P. Hansasuta5, N. Townamchai6

    1Nephrology division, Department of medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 2King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 3Bamrasnaradura infectious disease institute, Bangkok, Thailand, 4Infectious diseases, Department of medicine, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 5Department of Microbiology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand, 6Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital, Bangkok, Thailand

    *Purpose: Immunosuppression can impair immunological responses after vaccination in kidney transplant recipients (KTR). However, little is known about the effect of the booster dose of…
  • 2022 American Transplant Congress

    Recipient and Center Factors Associated with Immunosuppression Practice Beyond the First Year After Liver Transplantation

    T. Bittermann1, D. Goldberg2

    1University of Pennsylvania, Philadelphia, PA, 2University of Miami, Miami, FL

    *Purpose: To investigate patient and center factors associated with differences in immunosuppression management in the first 5 years after LT.*Methods: A retrospective cohort of 11,326…
  • 2022 American Transplant Congress

    Association Between Time in Therapeutic Range for Warfarin and Time in Therapeutic Range for Calcineurin Inhibitors in Patients That Received Left Ventricular Assist Devices as Bridge to Transplant

    G. Flajc1, X. Huang2, C. Minard2, M. Manson1, Z. Truman1

    1Baylor St. Luke's Medical Center, Houston, TX, 2Baylor College of Medicine, Houston, TX

    *Purpose: Medication nonadherence is a leading cause of avoidable graft failure post-transplant. The relationship between medication adherence in patients with left ventricular assist devices (LVADs)…
  • 2022 American Transplant Congress

    Donor-Specific T Cell Senescence In Operationally Tolerant Liver Transplant Recipients

    K. Deng1, N. Tanimine2, C. Breeden3, B. Burrell3, G. Gaile3, K. Lee1, R. Matheson1, F. Qiang1, C. Rickert1, C. LeGuern1, J. Markmann1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Department of Gastroenterological and Transplantation Surgery, Hiroshima University, Hiroshima, Japan, 3Immune Tolerance Network, Bethesda, MD

    *Purpose: Recent evidence indicates a correlation in liver transplant recipients between successful operational tolerance (OT) post immunosuppression withdrawal (ISW) with both recipient age and time…
  • 2022 American Transplant Congress

    Standard Induction with Basiliximab versus no Induction in Low Immunological Risk Kidney Transplant Recipients: Study Protocol for a Randomized Controlled Trial

    A. Ajlan1, H. Aleid1, T. Ali1, H. Joharji1, Z. Alabdulkarim1, T. Aburiash1, K. Almeshari1, A. Nazmi1, Y. Shah1, E. Devol1, D. Alkortas1, D. Broering1, I. Alahmadi1, A. Ullah1, A. Alotaibi1, A. Aljedai2

    1KFSHRC, RIYADH, Saudi Arabia, 2MOH, RIYADH, Saudi Arabia

    *Purpose: To compare different induction therapeutic strategies with 2 doses of basiliximab vs. no induction in low immunologic risk kidney transplant recipients as per KFSHRC…
  • 2022 American Transplant Congress

    Impact of Belatacept on Clinical Outcomes in Lung Transplant Patients with Antibody-Mediated Rejection

    L. Zaffiri, R. Hallak, S. Leonard, M. Neely, A. Hulber, H. Berry, K. A. Young, J. M. Reynolds

    Duke University, Durham, NC

    *Purpose: Antibody-mediated rejection (AMR) is cause of significant morbidity and mortality in lung transplant recipients (LTRs). An optimal therapeutic regimen is still lacking. Recent evidence…
  • 2022 American Transplant Congress

    Induction of Tacrolimus Clearance by Steroids Varies by Cyp3a5 Genotype in Kidney Transplant Recipients: A Drug-Drug-Gene Interaction

    P. A. Jacobson1, A. Saqr1, M. Al-Kofahi1, D. P. Schladt2, W. Guan3, W. S. Oetting1, R. Mannon4, C. R. Dorr5, R. P. Remmel1, G. C. Onyeaghala6, B. Wu3, A. K. Israni7, A. Matas8

    1Univ of MN, College of Pharmacy, Minneapolis, MN, 2Hennepin Health Research Institute, Minneapolis, MN, 3Univ of MN, Biostatistics, Minneapolis, MN, 4Univ of Nebraska, Dept of Medicine, Omaha, NE, 5Hennepin Health Research Institute and Dept of Medicine, Minneapolis, MN, 6Hennepin Healthcare Research Institute, Minneapolis, MN, 7Hennepin Health Dept of Medicine and Univ of MN, Minneapolis, MN, 8University of MN, Dept of Surgery, Minneapolis, MN

    *Purpose: Tacrolimus (TAC) is the primary immunosuppressant used in organ transplantation. TAC is a substrate for CYP3A4/5. These enzymes are inhibited or induced by multiple…
  • 2022 American Transplant Congress

    Viral-Specific Cytotoxic T-Cell Responses in Hla-Sensitized Kidney Transplant Patients Maintained on Everolimus and Low Dose Tacrolimus

    R. Zhang1, S. Ge1, M. Chu1, J. Kahwaji2, A. Karasyov1, D. Lovato1, A. Vo2, J. Choi2, M. Toyoda1, S. Jordan2

    1Transplant Immunology Laboratory, Cedars Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars Sinai Medical Center, Los Angeles, CA

    *Purpose: Post-transplant immunosuppression with “everolimus + reduced dose tacrolimus” (Ev + Taclow) is reported to reduce the risk of viral infections compared to standard doses…
  • 2022 American Transplant Congress

    The Successful Use of De Novo Belatacept with Reduced Dose Tacrolimus to Mitigate the Risks of Delayed Graft Function in Kidney Transplantation

    E. Siskind1, J. Splinter1, C. Taing1, A. Adekile2, S. Njim1, S. Shah1, R. Plews3, D. Conti4, S. Patel2

    1Center for Transplantation, University Medical Center of Southern Nevada, Las Vegas, NV, 2University Medical Center of Southern Nevada, Las Vegas, NV, 3Center for Transplantation, Albany Medical Center, Albany, NY, 4Albany Medical Center, Albany, NY

    *Purpose: The new kidney allocation system has caused increased organ travel times and therefore increased cold ischemia time. Furthermore, the change in the priority to…
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