ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunoglobulins (Ig)"

  • 2019 American Transplant Congress

    The Effect of Intravenous Immunoglobulin on Human Complement-Dependent Cytotoxicity of Pig Cells: Benefit? Or Harm?

    T. Yamamoto1, Q. Li1, A. Banks1, H. Iwase1, D. Ayares2, D. K. Cooper1, H. Hara1

    1Xenotransplantation Program, Department of Surgery, University of Alabama at Birmingham, Birmingham, AL, 2Revivicor, Blacksburg, VA

    *Purpose: Xenoreactive antibodies and complement play an important role in pig xenograft rejection. Intravenous immunoglobulin (IVIG) is widely used in desensitization protocols and for the…
  • 2019 American Transplant Congress

    A Clinical Analysis for Low-Dose Immunoglobulin United with Plasmapheresis in High Sensitization Renal Transplantation Recipients

    L. Xu1, J. Zhang2

    1Chinese PLA General Hospital Eighth Medical Centre, Beijing, China, 2Nursing Department, Chinese PLA General Hospital, Beijing, China

    *Purpose: To analyze the role of low-dose intravenous immunoglobulin (IVIG) united with plasmapheresis in high sensitization renal transplantation recipients.*Methods: Four patients with high levels of…
  • 2019 American Transplant Congress

    Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy

    M. Ma, P. Chhabra, K. Brayman

    Surgery, University of Virginia, Charlottesville, VA

    *Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…
  • 2018 American Transplant Congress

    APRIL/BLyS Blockade Improves Depletion of Antibody Secreting B Cells Compared to BLyS Blockade Alone in Sensitized Murine Kidney Transplant Model

    N. Bath,1 X. Ding,1 N. Wilson,2 B. Verhoven,1 A. Sukhwal,1 L. Coons,1 S. Panzer,2 A. Djamali,2 R. Redfield.1

    1Surgery, University of Wisconsin, Madison, WI; 2Medicine, University of Wisconsin, Madison, WI.

    Introduction: Antibody mediated rejection (AMR) remains a significant problem in highly sensitized individuals undergoing kidney transplantation. APRIL (A Proliferation Inducing Ligand) and BLyS (B Lymphocyte…
  • 2018 American Transplant Congress

    Identification of Human SIRPa Diversity That Could Regulate Innate Allorecognition

    A. Friday,1 H. Dai,1 A. Williams,1 M. Oberbarnscheidt,1 J. Danska,2 F. Lakkis.1

    1Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA; 2Immunology and Medical Biophysics, University of Toronto, Toronto, ON, Canada.

    Innate allorecognition is a process by which myeloid cells, such as monocytes, distinguish syngeneic from allogeneic cells. Monocytes that recognize donor cells as non-self differentiate…
  • 2018 American Transplant Congress

    The Complexity of HLA-DQ

    D. Pinelli, A. Tambur.

    Northwestern University, Chicago.

    Historically, HLA-DQ antigens and antibodies (Ab) were difficult to classify due to the lack of serological typing reagents. However, with the advent of molecular typing…
  • 2018 American Transplant Congress

    Comparison of C1Q Binding and Flow Cytometric Crossmatch Results Provides an Accurate Evaluation of Hypersensitive Kidney Transplant Patients

    E. Eksioğlu-Demiralp,1 A. Türkmen,2 B. Yelken,2 S. Görçin,2 O. Elbasi,1 F. Yalçin,3 B. Koçak,2 C. Karatas,4 M. Tuncer,4 M. Altinel.3

    1Tissue Typing and Immunology Laboratory, Memorial Health Group, Istanbul, Turkey; 2Sisli Hospital Transplantation Unit, Memorial Health Group, Istanbul, Turkey; 3Hizmet Hospital Transplantation Unit, Memorial Health Group, Istanbul, Turkey; 4Atasehir Hospital Transplantation Unit, Memorial Health Group, Istanbul, Turkey.

    Measurement of C1q binding to Donor specific antibodies (DSA) gives transplantation chance to hypersensitive patients having non-binding high amount of anti-HLA antibodies. In our series…
  • 2018 American Transplant Congress

    Temporal Variability of IgG Subclasses

    D. Pinelli, M. Gopalakrishnan, A. Joong, P. Thrush, A. Tambur.

    Northwestern University, Chicago; Lurie Children's Hospital, Chicago.

    The temporal model of IgG subclass switching supports sequential IgG conversion; however, the diversity of previously stimulated B cells is known to shape responses in…
  • 2018 American Transplant Congress

    The Results of Plasmapheresis and Anti-CD20 Based Desensitization without Intravenous Immunoglobulin in Positive Crossmatch Kidney Transplants

    H. Kwon, Y. KIm, J. Choi, S. Shin, J. Jung, M. Cho, J. Kim, D. Han.

    Asan Medical Center, Seoul, Korea.

    This study examined the mid-term clinical outcomes in positive crossmatch kidney transplants (XMKT) for patients who received desensitization with plasmapheresis (PP) and anti-CD20 based regimens…
  • 2018 American Transplant Congress

    Early Adjunctive Treatment with Human Cytomegaly Virus (CMV) Immunoglobulin Increased CMV-Free Survival after Heart Transplantation

    M. Barten,1 C. Neumaier,1 A. Bernhardt,1 M. Rybczynski,2 R. Plaetke,3 H. Reichenspurner.1

    1Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany; 2General and Interventional Cardiology, University Heart Center Hamburg, Hamburg, Germany; 3Institute of Medical Biometry and Epidemiology, University Hospital Eppendorf Hamburg, Hamburg, Germany.

    Purpose: There is still an ongoing discussion whether a prophylactic or a preemptive therapy against cytomegalovirus (CMV) is superior to reduce the incidence of CMV…
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