2019 American Transplant Congress
The Effect of Intravenous Immunoglobulin on Human Complement-Dependent Cytotoxicity of Pig Cells: Benefit? Or Harm?
*Purpose: Xenoreactive antibodies and complement play an important role in pig xenograft rejection. Intravenous immunoglobulin (IVIG) is widely used in desensitization protocols and for the…2019 American Transplant Congress
A Clinical Analysis for Low-Dose Immunoglobulin United with Plasmapheresis in High Sensitization Renal Transplantation Recipients
*Purpose: To analyze the role of low-dose intravenous immunoglobulin (IVIG) united with plasmapheresis in high sensitization renal transplantation recipients.*Methods: Four patients with high levels of…2019 American Transplant Congress
Prevention of Islet Allo- and Xenograft Rejection with Immunoglobulin M Immunotherapy
Surgery, University of Virginia, Charlottesville, VA
*Purpose: To investigate if IgM therapy mitigates islet allo- and xenotransplant rejection and promotes permanent islet survival.*Methods: 1) New onset diabetic NOD mice (n=14) were…2018 American Transplant Congress
Early Adjunctive Treatment with Human Cytomegaly Virus (CMV) Immunoglobulin Increased CMV-Free Survival after Heart Transplantation
Purpose: There is still an ongoing discussion whether a prophylactic or a preemptive therapy against cytomegalovirus (CMV) is superior to reduce the incidence of CMV…2018 American Transplant Congress
Evanescent Antibodies: A Report on the Natural History of Anti-Blood Group A2 Antibodies and Their Rapid Resolution in Patients Awaiting A2 to B Transplantation
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
Introduction: Despite the benefits of A2 to B transplants, centers have been reluctant to adopt such a program due to unanswered questions including whether elevation…2018 American Transplant Congress
The Effect of Intravenous Immunoglobulin on In Vitro Human Antibody Binding to Genetically-Engineered Pig Cells – Relevance to Clinical Xenotransplantation –
Background: Xenoreactive antibodies play an important role in xenograft rejection. Intravenous immunoglobulin (IVIG), which has anti-complement activity and contains anti-idiotypic antibodies, is widely used for…2018 American Transplant Congress
Assessment of Donor Specific Anti-HLA Antibodies throughout SLK Transplantation
Simultaneous Liver-Kidney transplantation provides a mechanism to protect the transplanted kidney from recognition by the recipient's immune response compared to solitary kidney transplant alone. High…2018 American Transplant Congress
APRIL/BLyS Blockade Improves Depletion of Antibody Secreting B Cells Compared to BLyS Blockade Alone in Sensitized Murine Kidney Transplant Model
1Surgery, University of Wisconsin, Madison, WI; 2Medicine, University of Wisconsin, Madison, WI.
Introduction: Antibody mediated rejection (AMR) remains a significant problem in highly sensitized individuals undergoing kidney transplantation. APRIL (A Proliferation Inducing Ligand) and BLyS (B Lymphocyte…2018 American Transplant Congress
Identification of Human SIRPa Diversity That Could Regulate Innate Allorecognition
Innate allorecognition is a process by which myeloid cells, such as monocytes, distinguish syngeneic from allogeneic cells. Monocytes that recognize donor cells as non-self differentiate…2018 American Transplant Congress
The Complexity of HLA-DQ
Northwestern University, Chicago.
Historically, HLA-DQ antigens and antibodies (Ab) were difficult to classify due to the lack of serological typing reagents. However, with the advent of molecular typing…
American Transplant Congress abstracts