ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Immunogenicity"

  • 2018 American Transplant Congress

    Antibody-Verified Eplet Mismatches as Determinants of Premature Kidney Transplant Loss

    R. Sapir-Pichhadze,1 X. Zhang,1 A. Ferradji,1 A. Madbouly,2 S. Fingerson,2 K. Tinckam,5 H. Gebel,3 H. Cardinal,4 B. Foster.1

    1McGill University, Montreal, Canada; 2National Marrow Donor Program, Minneapolis; 3Emory University Hospital, Atlanta; 4CHUM, Montreal, Canada; 5University Health Network, Toronto, Canada.

    Introduction: HLA matching at the epitope level offers new opportunities to identify compatible donors for transplant candidates. HLAMatchmaker deduces B-cell epitope ('eplets' in HLAMatchmaker) mismatches…
  • 2018 American Transplant Congress

    Novel Function of TIE2 in Immunoregulation

    C. Ghosh, T. Agur, A-.L. Mak, S. Pal, J. Wedel, B. David.

    Transplant Research Program, Boston Children's Hospital, Boston, MA.

    The immunogenicity of graft microvascular endothelial cells (ECs) has immense biological significance in the modulation of the local intragraft microenvironment. EC may either support Teffector…
  • 2018 American Transplant Congress

    Rapamycin Impairs Human Endothelial Cell Alloimmunogenicity Independent of PD-1/PD-1 Ligand Inhibitory Signaling

    Q. Gao, V. Bendersky, A. Kirk, H. Xu.

    Department of Surgery, Duke University Medical Center, Durham, NC.

    Rapamycin prevents costimulation blockade (CoB)-resistant rejection in mice and primates, and early human data suggests a similar salutary effect. We have hypothesized that one mechanism…
  • 2018 American Transplant Congress

    Genome Wide Non-HLA Alloimmunity Contributes to Graft Loss after Kidney Transplantation

    R. Reindl-Schwaighofer, A. Heinzel, A. Kainz, K. Jelencsics, O. Viklicky, G. Böhmig, G. Fischer, B. Keating, R. Oberbauer.

    Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; Department of Nephrology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; Transplant Institute, University of Pennsylvania, Philadelphia, PA.

    BackgroundChronic rejection is the main cause of renal transplant loss after the first year and has mostly been attributed to alloimmune responses against human leukocyte…
  • 2018 American Transplant Congress

    Not All HLA Mismatches Are Equal: Determining the Relative De Novo DSA Induction Capacity of HLA Mismatches

    V. Jucaud,1 L. Rebellato,2 K. Briley,2 A. Maldonado,3 C. Haisch,2 P. Bolin,2 S. Kendrick,4 H. Jones,4 K. McLawhorn,4 D. Leeser,2 M. Everly.1

    1Terasaki Research Institute, Los Angeles, CA; 2East Carolina University, Greenville, NC; 3Vidant Medical Center, Greenville, NC; 4Eastern Nephrology Associates, Greenville, NC.

    We studied the immunogenicity, defined as the development of de novo DSA (dnDSA), of HLA-A, -B, -DR and -DQ MM (serological) in a cohort of…
  • 2018 American Transplant Congress

    Anti-IdeS Antibodies in IVIg and Its Effect on IdeS Activity

    A. Runström,1 S. Järnum,1 S. Jordan,2 L. Winstedt,1 C. Kjellman.1

    1Hansa Medical AB, Lund, Sweden; 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles.

    ObjectiveEvaluate how and why intravenous gamma globulin (IVIg) affects IdeS-cleavage of IgG.IntroductionIgG degrading enzyme of Streptococcus pyogenes (IdeS) cleaves human IgG in two steps, first…
  • 2018 American Transplant Congress

    The Relative Immunogenicity of HLA Mismatches in Adult Liver Transplant Recipients

    V. Jucaud,1 A. Shaked,2 M. DesMarais,3 P. Sayre,3 M. Everly.1

    1Terasaki Research Institute, Los Angeles, CA; 2University of Pennsylvania, Philadelphia, PA; 3Immune Tolerance Network, Seattle, WA.

    Determining the immunogenicity of HLA mismatches (MM) may help preventing the appearance of de novo DSA (dnDSA) and avoiding antibody-mediated injuries.We studied the development of…
  • 2018 American Transplant Congress

    Ex-Vivo Pretreatment of Islets with Mitomycin-C Have a Potential to Induce Specific Immune Response for Peripheral Tolerance

    N. Sato, A. Kenjo, T. Kimura, R. Okada, T. Ishigame, Y. Kofunato, J. Watanabe, M. Muto, S. Suzushino, T. Shimura, S. Marubashi.

    Hepato-Biliary-Pancreatic and Transplant Sugery, Fukushima Medical University, Fukushima, Japan.

    Background.Our previous study demonstrated that ex-vivo Mitomycin-C(MMC) pretreatment of islets reduced immunogenicity, enhancing graft survival without immunosuppression(IS). However, it is still unclear whether donor specific…
  • 2017 American Transplant Congress

    A Novel Microsurgical Penis Transplant Model to Study Distinct Immunologic Features of Urogenital Tissues.

    G. Furtmüller, S. Fidder, B. Simons, B. Oh, B. Kern, D. Lough, M. Chicco, C. Brayton, W. Lee, D. Cooney, R. Redett, G. Brandacher.

    Johns Hopkins University, Baltimore, MD

    Background: Penis transplantation has been successfully employed in the recent past and represents an exciting avenue for restoration of male urogenitalia and function by using…
  • 2017 American Transplant Congress

    Inhibition of Heat Shock Protein 90 Suppresses the Expression of MHC Class I Molecules, but Not MHC Class II Molecules, on Endothelial Cells in Allografts.

    T. Tanaka, T. Maehana, N. Masumori.

    Urology, Sapporo Medical University, Sapporo, Japan

    Purpose: Heat shock protein 90 (HSP90) is a ubiquitously expressed molecular chaperone that is associated with the correct activation of client proteins. Important roles of…
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