2019 American Transplant Congress
Emergence of Anti-HLA Antibodies after Catch-Up Vaccinations in Pediatric Kidney Transplant Candidates
*Purpose: Evaluate anti-HLA antibody (Ab) emergence after catch-up vaccinations in pediatric kidney transplant candidates (PKTC).*Methods: A single center retrospective review of PKTC 25% from baseline,…2019 American Transplant Congress
Mismatched Epitope and De Novo DSA Development: An Analysis of the Benefit and Benefit-EXT Renal Transplant Cohorts
*Purpose: De novo donor-specific HLA antibodies (dnDSA) target epitopes rather than whole antigens, and their development is associated with the mismatched HLA antibody epitope load…2019 American Transplant Congress
Computational Assessment of T-cell and B-cell Allorecognition to Predict Donor HLA Immunogenicity
*Purpose: Donor-specific alloantibody (DSA) development after solid-organ transplantation is a major cause of graft loss, and limits future transplant options. We have previously shown that…2019 American Transplant Congress
Physiochemical Hla Properties Identify Low Immunogenic Donor/recipient Pairs Predicting Long-term Kidney Graft Survivals
1Gift of Life Michigan, Ann Arbor, MI, 2University of Toledo, Toledo, OH
*Purpose: Although it is well-recognized that HLA matching improves the long-term kidney graft survival, less than 10% of transplants are currently HLA matched. We measured…2018 American Transplant Congress
Antibody-Verified Eplet Mismatches as Determinants of Premature Kidney Transplant Loss
Introduction: HLA matching at the epitope level offers new opportunities to identify compatible donors for transplant candidates. HLAMatchmaker deduces B-cell epitope ('eplets' in HLAMatchmaker) mismatches…2018 American Transplant Congress
Novel Function of TIE2 in Immunoregulation
Transplant Research Program, Boston Children's Hospital, Boston, MA.
The immunogenicity of graft microvascular endothelial cells (ECs) has immense biological significance in the modulation of the local intragraft microenvironment. EC may either support Teffector…2018 American Transplant Congress
Rapamycin Impairs Human Endothelial Cell Alloimmunogenicity Independent of PD-1/PD-1 Ligand Inhibitory Signaling
Department of Surgery, Duke University Medical Center, Durham, NC.
Rapamycin prevents costimulation blockade (CoB)-resistant rejection in mice and primates, and early human data suggests a similar salutary effect. We have hypothesized that one mechanism…2018 American Transplant Congress
Genome Wide Non-HLA Alloimmunity Contributes to Graft Loss after Kidney Transplantation
BackgroundChronic rejection is the main cause of renal transplant loss after the first year and has mostly been attributed to alloimmune responses against human leukocyte…2018 American Transplant Congress
Not All HLA Mismatches Are Equal: Determining the Relative De Novo DSA Induction Capacity of HLA Mismatches
We studied the immunogenicity, defined as the development of de novo DSA (dnDSA), of HLA-A, -B, -DR and -DQ MM (serological) in a cohort of…2018 American Transplant Congress
Anti-IdeS Antibodies in IVIg and Its Effect on IdeS Activity
ObjectiveEvaluate how and why intravenous gamma globulin (IVIg) affects IdeS-cleavage of IgG.IntroductionIgG degrading enzyme of Streptococcus pyogenes (IdeS) cleaves human IgG in two steps, first…
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