Articles tagged "IgG"

2021 American Transplant Congress
Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model
M. Manook¹, W. Flores², R. Schmitz¹, Z. Fitch¹, J. Yoon¹, Y. Bae¹, B. I. Shaw¹, M. Harnois³, S. Permar³, A. Kirk¹, D. Magnani², J. Kwun¹, S. Knechtle¹
¹Duke Transplant Center, Duke University Medical Center, Durham, NC, ²Massbiologics, University of Massachusetts Medical School, Boston, MA, ³Human Vaccine Institute, Duke University Medical Center, Durham, NC
*Purpose: In transplantation, plasmapheresis and IVIg provide the mainstay of treatment directed at reducing or removing circulating donor specific antibody (DSA), yet both have limitations.…
2021 American Transplant Congress
Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts
V. Gorbacheva, R. Fan, W. Baldwin, R. Fairchild, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…
2020 American Transplant Congress
ABH Subtype-Specific Tolerance after ABO-Mismatched Hematopoietic Cell Transplantation
B. Motyka¹, A. Halpin¹, J. Pearcey¹, A. Kariminia², A. Halevy², S. Maier¹, A. Halevy², P. Subrt², C. W. Cairo¹, G. D. Cuvelier³, K. R. Schultz², L. J. West¹
¹Alberta Transplant Institute, University of Alberta, Edmonton, AB, Canada, ²British Columbia Children’s Hospital Research Institute, University of British Columbia, Vancouver, BC, Canada, ³CancerCare Manitoba, University of Manitoba, Winnipeg, MB, Canada
*Purpose: ABO-mediated immunity is reported to have minimal detrimental impact after ABO-mismatched hematopoietic cell transplantation (HCT). Patients are generally presumed ‘tolerant’ with regard to ABO.…
2020 American Transplant Congress
Risk Factors for Losing Varicella Immunity after Pediatric Kidney Transplantation
H. Pizzo¹, J. Mirocha², J. Garrison¹, P. R. Soni³, S. Nadipuram³, D. Puliyanda¹
¹Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Biostatistics Core, Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, ³Pediatric Infectious Disease, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Vaccination against varicella zoster (VZV) pre-kidney transplant (kid tx) can help prevent severe disseminated VZV disease in immunosuppressed patients (pts) post-tx. Despite confirmation of…
2020 American Transplant Congress
Outcomes of a Pre-Transplant Desensitization Protocol with Carfilzomib, Plasmapheresis, and IVIG for Broadly Sensitized Lung Transplant Candidates: A Case Series
S. Fredrick¹, C. Iasella², C. Moore¹, M. Mangiola³, Q. Xu³, C. Ensor⁴, D. Riciutti², C. LaFratte², P. Sanchez³, M. Morrell³, J. McDyer³, A. Zeevi³
¹Department of Pharmacy, UPMC Presbyterian, Pittsburgh, PA, ²University of Pittsburgh School of Pharmacy, Pittsburgh, PA, ³University of Pittsburgh School of Medicine, Pittsburgh, PA, ⁴Department of Pharmacy, AdventHealth, Orlando, FL
*Purpose: The presence of anti-human leukocyte antigen (HLA) antibodies in lung transplant candidates leads to increased wait list times and antibody-mediated rejection (AMR) post-transplant. We…
2020 American Transplant Congress
Marginal Zone B Cells Support Donor-Specific Alloantibody Responses to Heart Allografts
V. Gorbacheva, R. Fan, W. Baldwin, R. Fairchild, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Production of high affinity isotype-switched donor specific alloantibodies (DSA) after transplantation is associated with germinal center formation by follicular (FO) B cells whereas the…
2019 American Transplant Congress
Anti-Donor M H C Class I I Alloantibody Induce Glomerular Injury in Mouse Renal Allografts Subjected to Prolonged Cold Ischemia
V. Gorbacheva, R. Fan, A. Beavers, R. Fairchild, W. Baldwin, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Prolonged cold ischemia storage (CIS) of donor transplants is a major risk factor for acute and chronic graft tissue injury.The goal of this study…
2019 American Transplant Congress
IgG Glycosylation Causes Podocyte Injury in Transplant Glomerulopathy through Calcium Calmodulin Kinase IV
R. Bhargava, K. Maeda, M. Pavlakis, G. Tsokos
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
*Purpose: Transplant glomerulopathy(TG) is a major cause of late allograft loss. Increase in urine podocin/creatinine ratio in TG signifies acceleration of podocyte detachment from glomerular…
2019 American Transplant Congress
Characterization of HLA Antibodies by C3d Assay and IgG Subclasses in Sensitized Kidney Transplant Patients
A. Casillas-Abundis, J. M. Arreola-Guerra, J. Alberu, M. I. Solis-G, L. Llorente, J. Granados, M. Vilatoba, R. Cruz-Martinez, L. Morales-Buenrostro, A. G. Contreras
Instituto Nacional de Ciencias Medicas y Nutricion SZ, Mexico City, Mexico
*Purpose: To determine the detection rate of IgG subclasses (IgGsc) and C3d-binding HLA-antibodies (abs) in a cohort of highly sensitized kidney transplant patients.*Methods: We evaluated,…
2019 American Transplant Congress
Clazakizumab (CLZ, Anti-IL-6 Monoclonal Antibody) Treatment of Patients (Pts) with Chronic Antibody-Mediated Rejection (cABMR) Reduces Total Immunoglobulin (Ig) and Anti-HLA IgG Antibody Levels
B. Shin, N. F. Ammerman, A. A. Vo, X. Zhang, S. C. Jordan, M. Toyoda
Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: We have recently reported successful use of Tocilizumab (TCZ), an anti-IL-6 receptor (R) monoclonal antibody, for cABMR treatment in HLA-sensitized kidney transplant (KTx) Pts.…