Articles tagged "HLA matching"

2020 American Transplant Congress
HLA Diversity Affects Epitope Mismatch Cutoffs Utilized to Predict De Novo DSA Development and Graft Rejection in Renal Transplant Patients
A. Ram¹, S. Dhingra², H. Quach¹, P. T. Jindra¹
¹Immune Evaluation Laboratory-Surgery, Baylor College of Medicine, Houston, TX, ²Pathology, Baylor College of Medicine, Houston, TX
*Purpose: Recent studies have investigated epitope matching in order to determine its predictive power in determining renal transplant outcomes, both in terms of de novo…
2020 American Transplant Congress
Eplet Mismatch Imputed from HLA Serotype-Level Data Can Improve Risk Stratification for Kidney Allograft Loss
A. Heinzel, R. Reindl-Schwaighofer, A. Kainz, K. Hu, R. Oberbauer
Department of Medicine III - Division of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria
*Purpose: HLA-Epitope mismatch improves risk stratification following kidney transplantation. Based on population data, high resolution HLA types required for epitope prediction can be imputed based…
2020 American Transplant Congress
Is the Epitope Mismatch Load Enough to Identify HLA-DQ Mismatches with a Low Risk for De Novo DSA Development?
V. Jucaud¹, M. Stegall², C. Schinstock², R. Heilman³, L. Rebellato⁴, M. Samaniego-Picota⁵, D. Leeser⁴, M. Gandhi², J. Beaumont¹, M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²Mayo Clinic, Rochester, MN, ³Mayo Clinic, Phoenix, AZ, ⁴East Carolina University, Greenville, NC, ⁵Henry Ford Transplant Institute, Detroit, MI
*Purpose: The development of de novo donor-specific anti-HLA antibodies (dnDSA) remains a major risk factor for poor long-term kidney allograft outcomes. In particular, anti-HLA-DQ dnDSAs,…
2020 American Transplant Congress
Improving Access to Transplantation and Outcomes for African American Patients
D. Bekbolsynov, O. Ekwenna, B. Mierzejewska, J. Borucka, S. A. Khuder, M. Rees, R. Green, S. Stepkowski
University of Toledo, Toledo, OH
*Purpose: Black or African American patients are clearly disadvantaged in comparison to Caucasian patients both in terms of the access to kidney transplantation and post-transplant…
2020 American Transplant Congress
Failure to Launch; a Multi-Centre Study of Potential Live Donors in Southeast Nigeria
C. G. Okwuonu¹, G. O. Achor², Q. L. Ogana³, C. Kingsley⁴
¹Internal Medicine, Federal Medical Centre, Umuahia, Nigeria, ²Department of Surgery, Federal Medical Centre, Umuahia, Nigeria, ³Internal Medicine, Beatitudes Mediplex and Kidney Care Centre, Umuahia, Nigeria, ⁴Internal Medicine, Beatitudes Mediplex and Kidney Care Centre, Aba, Nigeria
*Purpose: To determine the socio-demographic characteristics of potential living kidney donors, donor motivation, incidental findings on clinical evaluation and some identified factors that precluded eventual…
2020 American Transplant Congress
The Clinical Relevance of cPRA in 0-ABDRDQ Mismatched Kidney Transplants
J. H. Lan¹, D. Chang¹, M. Kadatz¹, J. Gill¹, H. M. Gebel², J. S. Gill¹
¹Medicine, Division of Nephrology, University of British Columbia, Vancouver, BC, Canada, ²Pathology, Emory University, Atlanta, GA
*Purpose: The clinical relevance of immune sensitization as measured by cPRA in kidney transplantation remains uncertain.*Methods: We identified 4,057 adult, first, kidney only transplant recipients…
2020 American Transplant Congress
Compatible Pairs- Providingan Option to Upgrade
V. Chipman¹, M. Cooper², S. Flechner³, G. Hil⁴, D. Leeser⁵, D. Mandelbrot⁶, M. Ronin⁴, D. Segev⁷, S. Syed⁸, A. Thomas⁹, A. Waterman¹⁰, G. R. Roll¹¹
¹Kidney Transplant, UCSF, San Francisco, CA, ²Georgertown, Washington, DC, ³Cleavland Clinic, Cleavland, OH, ⁴NKR, Babylon, NY, ⁵East Carolina Univ, Greenville, NC, ⁶University of Wisconsin, Madison, WI, ⁷Johns Hopkins, Boltimore, MD, ⁸UCSF, San Francisco, CA, ⁹Johns Hopkins, Baltimore, MD, ¹⁰UCLA and Terasaki Research Institute, Los Angeles, CA, ¹¹Surgery, Division of Transplant, UCSF, San Francisco, CA
*Purpose: Compatible pairs (CPs) can enter an exchange program instead of donating directly. These pairs increase transplants (txp) by providing additional donors within an exchange…
2020 American Transplant Congress
Noninvasive Genotyping of Donor’s HLA in Kidney Transplant Patients by Target Capture Sequencing
T. Jiang, L. Shu, F. Liu, H. Liu, J. Ge
AlloDx, Shanghai; Suzhou, China
*Purpose: Antibody-mediated rejection (ABMR) is the major cause of kidney transplant failure, which requires donor-specific antibodies (DSA) for a definitive diagnosis based on Banff 2013.…
2020 American Transplant Congress
The Impact of HLA-DQ Molecular Mismatches on De Novo Occurrence of Donor-Specific Anti-HLA Antibodies after Kidney Transplantation: An Observational Cohort Study
A. Senev¹, M. Coemans¹, V. Van Sandt², E. Van Loon¹, J. Callemeyn¹, B. Sprangers¹, D. Kuypers¹, M. Emonds¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²HILA, Red Cross-Flanders, Mechelen, Belgium
*Purpose: Evaluating HLA molecular mismatches (MM) instead of antigen mismatches might be a better tool to assess donor-recipient HLA incompatibility and provide a better risk…
2020 American Transplant Congress
HLA Molecular Mismatch Analysis in Recipients of Kidney Plus Hematopoietic Stem/Facilitating Cell Transplant Tolerance Induction Protocol
C. Garcia-Sanchez¹, V. Kosmoliaptsis², H. Copley², J. Leventhal¹, S. Ildstad³
¹NU, Chicago, IL, ²Cambridge, Cambridge, United Kingdom, ³U of Louisville, Lousville, KY
*Purpose: To evaluate the potential role of HLA molecular mismatch (MM) analysis in predicting outcomes in a cohort of HLA-mismatched, related and unrelated recipients of…