2022 American Transplant Congress
HLA-DRB1 and DQB1 Amino Acid Mismatches as Determinants of Kidney Allograft Failure
*Purpose: It was previously reported that HLA-DRB1 amino acid (AA) mismatches (MMs) at peptide-binding pockets of this molecule account for significant incremental risk of kidney…2022 American Transplant Congress
Understanding The Modification Of Eplet Mismatch Risk By Immunosuppression Regimen
*Purpose: Solid organ transplant donor-recipient eplet mismatch has been correlated with subsequent donor specific antibody (DSA) formation, antibody mediated rejection, and overall rejection rates. However,…2022 American Transplant Congress
The Effects of Race-Matching in Small Intestine Transplantation
*Purpose: We sought to investigate whether race-matching in small intestine (SI) transplantation correlates with better transplantation outcomes, as well as lower odds of graft rejection.*Methods:…2022 American Transplant Congress
Improving Value Delivery in Compatible Living Donor Kidney (CLD) Transplant Through Zero-Low Eplet Mismatch via National Kidney Registry (NKR)
1Intermountain Medical Center, Murray, UT, 2CareDX, South San Francisco, CA
*Purpose: Despite advances in diagnostics and therapeutics, kidney allograft survival rates have not increased considerably. Kidney For Life (KFL) through NKR aims to increase access…2022 American Transplant Congress
Does Black Race Modify the Risk of Transplant Failure Associated with HLA Mismatch in First Adult Kidney Allografts from Deceased Donors?
Tulane University, New Orleans, LA
*Purpose: Current US- based data suggests Black patients awaiting kidney re-transplantation are more likely to be highly sensitized compared to other races. Degree of HLA…2021 American Transplant Congress
Influence of HLA Compatibility on Bk Virus Associated Nephropathy Among Japanese Living Donor Kidney Transplant Recipients
*Purpose: BK polyomavirus-associated nephropathy (BKVN) after kidney transplantation is associated with a high morbidity and higher risk of graft loss. In this study, the relationship…2021 American Transplant Congress
Low Immunogenic Donors Improved Survival of Kidney Transplants in African American Recipients
1University of Toledo, Toledo, OH, 2Bowling Green State University, Bowling Green, OH
*Purpose: Kidney transplants fail more often in African American (AA) than in Caucasian (CAU) recipients. We calculated the hydrophobic mismatch score (HMS) from polymorphic amino…2021 American Transplant Congress
hlaR,” a Simplified Interface for the HLA Matchmaker Tool
1Surgery, Emory University, Atlanta, GA, 2Pathology, Emory University, Atlanta, GA
*Purpose: Functional epitopes, or eplets, represent a set of amino acids within three angstroms of one another that may not be sequentially contiguous but are…2021 American Transplant Congress
Clinical Outcomes and Racial Impact of HLA Matching in the Australian Deceased Donor Kidney Transplantation Program, 2000-2018
Department of Surgery, John Hunter Hospital, Newcastle, Australia
*Purpose: The Australian deceased donor (DD) kidney transplant program places a large emphasis on HLA matching despite a known disadvantage to ethnic minority groups. We…2021 American Transplant Congress
An HLA Class II Matching Strategy That Predicts De Novo Donor-specific HLA Antibody Formation Using Low Resolution HLA Types
*Purpose: The development of de novo donor-specific HLA antibodies (dnDSA) is predominantly against HLA-Class II antigens and is a function of the degree of HLA-DQ…
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