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American Transplant Congress abstracts

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Articles tagged "HLA matching"

  • 2022 American Transplant Congress

    Improving Value Delivery in Compatible Living Donor Kidney (CLD) Transplant Through Zero-Low Eplet Mismatch via National Kidney Registry (NKR)

    S. Anand1, J. Sanchez-Garcia1, W. Stapley1, J. Browning1, M. Egbert1, S. Dow1, A. Raza1, T. Srinivas2, D. Morris1

    1Intermountain Medical Center, Murray, UT, 2CareDX, South San Francisco, CA

    *Purpose: Despite advances in diagnostics and therapeutics, kidney allograft survival rates have not increased considerably. Kidney For Life (KFL) through NKR aims to increase access…
  • 2022 American Transplant Congress

    Does Black Race Modify the Risk of Transplant Failure Associated with HLA Mismatch in First Adult Kidney Allografts from Deceased Donors?

    K. Atiemo

    Tulane University, New Orleans, LA

    *Purpose: Current US- based data suggests Black patients awaiting kidney re-transplantation are more likely to be highly sensitized compared to other races. Degree of HLA…
  • 2022 American Transplant Congress

    HLA-DQ Mismatches Are More Likely to Be Listed as Unacceptable Antigens After Renal Graft Failure in African American Recipients as Compared to Other Racial/Ethnic Groups

    D. Isaacson1, M. W. Gmeiner2, V. Kosmoliaptsis3, J. D. Schold4, A. R. Tambur1

    1Northwestern University, Chicago, IL, 2London School of Economics, London, United Kingdom, 3Cambridge University, Cambridge, United Kingdom, 4Cleveland Clinic, Cleveland, OH

    *Purpose: Growing evidence suggests that donor-recipient mismatches at the HLA-DQ locus are the most immunogenic and pathogenic, evidenced by generation of DQ donor-specific antibodies (DSA).…
  • 2022 American Transplant Congress

    Impact of HLA Matching on Graft Survival in Kidney Transplant Recipients

    J. Miller1, N. Salkowski1, B. Thompson1, R. Kandaswamy2, P. Stock3, A. Israni1

    1Scientific Registry of Transplant Recipients, Minneapolis, MN, 2Department of Surgery, University of Minnesota Medical School, Minneapolis, MN, 3Department of Surgery, University of California San Francisco, San Francisco, CA

    *Purpose: This study aims to estimate the association of HLA matching at the A, B, DR, and DQ loci with posttransplant graft failure and patient…
  • 2022 American Transplant Congress

    Allo-Sensitization is Increased in Liver Transplant Recipients Following Ischemia-Reperfusion Injury

    R. A. Sosa, A. Q. Terry, Y. Yin, B. V. Naini, F. M. Kaldas, R. W. Busuttil, D. W. Gjertson, J. W. Kupiec-Weglinski, E. F. Reed

    UCLA, Los Angeles, CA

    *Purpose: Recipient sensitization to donor HLA antigens remains an important clinical problem in transplantation, leading to increased wait times to find a compatible donor and…
  • 2021 American Transplant Congress

    Clinical Outcomes and Racial Impact of HLA Matching in the Australian Deceased Donor Kidney Transplantation Program, 2000-2018

    M. Gramlick, M. Heer

    Department of Surgery, John Hunter Hospital, Newcastle, Australia

    *Purpose: The Australian deceased donor (DD) kidney transplant program places a large emphasis on HLA matching despite a known disadvantage to ethnic minority groups. We…
  • 2021 American Transplant Congress

    An HLA Class II Matching Strategy That Predicts De Novo Donor-specific HLA Antibody Formation Using Low Resolution HLA Types

    L. Hidalgo1, I. Martinez Juarez2, L. Morales Buenrostro2, S. Shojai3, P. Campbell1

    1University of Wisconsin Madison, Madison, WI, 2Instituto Nacional de Ciencias Medicas Y Nutricion Salvador Zubrian, Mexico City, Mexico, 3Medicine, University of Alberta, Edmonton, AB, Canada

    *Purpose: The development of de novo donor-specific HLA antibodies (dnDSA) is predominantly against HLA-Class II antigens and is a function of the degree of HLA-DQ…
  • 2021 American Transplant Congress

    Towards National Organ Sharing: Fair Distribution of Eplets in Canada

    S. Parto, B. Liu, W. Klement, S. Oikonomopoulos, I. Ragoussis, R. Sapir-Pichhadze

    McGill University, Montreal, QC, Canada

    *Purpose: Eplet matching is being promoted as a rational approach to prevent immune-mediated injuries in transplantation. We studied the frequencies of eplets in a Canadian…
  • 2021 American Transplant Congress

    Risk Stratification of Kidney Transplant Patients According to the Different Level of HLA-DQ Disparities

    A. Senev1, A. R. Tambur2, M. Naesens1

    1Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, 2Northwestern University, Chicago, IL

    *Purpose: It is becoming clear that de novo donor-specific antibodies (dnDSA) against HLA-DQ are the most prevalent and the leading cause of chronic antibody-mediated rejection…
  • 2021 American Transplant Congress

    Influence of HLA Compatibility on Bk Virus Associated Nephropathy Among Japanese Living Donor Kidney Transplant Recipients

    N. Fujiyama1, M. Saito2, R. Yamamoto2, R. Sagehashi2, T. Saito2, S. Kashima2, K. Numakura2, S. Narita2, T. Habuchi2, S. Satoh1

    1Center for Kidney Disease and Transplantaion, Akita University Hospital, Akita, Japan, 2Department of Urology, Akita University Graduate School of Medicine, Akita, Japan

    *Purpose: BK polyomavirus-associated nephropathy (BKVN) after kidney transplantation is associated with a high morbidity and higher risk of graft loss. In this study, the relationship…
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