2022 American Transplant Congress
A Novel Application of SRTR Data to Interrogate the Effects of HLA-DQ Mismatches in Kidney Transplantation
*Purpose: Single-center studies demonstrate de-novo HLA-DQ donor-specific antibodies (DSA) are the most common and pathogenic DSA. However, HLA-DQ is not accounted for in many kidney…2022 American Transplant Congress
Successful Transplantation of CPRA 95-100% HLA Incompatible (HLA I) KPD Candidates: A New Combined KPD Matching Strategy at a Single Centre
*Purpose: The six components of the new strategy are Universal flexible assignments of unacceptable antigens (UA); individualized deletion of carefully selected UA; inclusion of compatible…2022 American Transplant Congress
Does ABO/HLA Matching Matter in Uterus Transplantation?
1Baylor University Medical Center, Dallas, TX, 2Baylor Scott and White Dallas, Dallas, TX
*Purpose: Uterus transplantation (UTx) is the most commonly performed vascular composite allograft and is rapidly becoming an accepted treatment for absolute uterine-factor infertility (AUFI). There…2022 American Transplant Congress
Clinical Relevance of Class II HLA Mismatches in Living Donor Kidney Transplantation
*Purpose: The benefit of class II HLA matching is primarily shown in deceased donor kidney transplantation. The objective of this study was to determine the…2022 American Transplant Congress
HLA-DRB1 and DQB1 Amino Acid Mismatches as Determinants of Kidney Allograft Failure
*Purpose: It was previously reported that HLA-DRB1 amino acid (AA) mismatches (MMs) at peptide-binding pockets of this molecule account for significant incremental risk of kidney…2021 American Transplant Congress
Clinical Outcomes and Racial Impact of HLA Matching in the Australian Deceased Donor Kidney Transplantation Program, 2000-2018
Department of Surgery, John Hunter Hospital, Newcastle, Australia
*Purpose: The Australian deceased donor (DD) kidney transplant program places a large emphasis on HLA matching despite a known disadvantage to ethnic minority groups. We…2021 American Transplant Congress
An HLA Class II Matching Strategy That Predicts De Novo Donor-specific HLA Antibody Formation Using Low Resolution HLA Types
*Purpose: The development of de novo donor-specific HLA antibodies (dnDSA) is predominantly against HLA-Class II antigens and is a function of the degree of HLA-DQ…2021 American Transplant Congress
Towards National Organ Sharing: Fair Distribution of Eplets in Canada
McGill University, Montreal, QC, Canada
*Purpose: Eplet matching is being promoted as a rational approach to prevent immune-mediated injuries in transplantation. We studied the frequencies of eplets in a Canadian…2021 American Transplant Congress
Risk Stratification of Kidney Transplant Patients According to the Different Level of HLA-DQ Disparities
*Purpose: It is becoming clear that de novo donor-specific antibodies (dnDSA) against HLA-DQ are the most prevalent and the leading cause of chronic antibody-mediated rejection…2021 American Transplant Congress
Influence of HLA Compatibility on Bk Virus Associated Nephropathy Among Japanese Living Donor Kidney Transplant Recipients
*Purpose: BK polyomavirus-associated nephropathy (BKVN) after kidney transplantation is associated with a high morbidity and higher risk of graft loss. In this study, the relationship…
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