2020 American Transplant Congress
Bone Marrow Plasma Cell Heterogeneity Drives Resistance of Proteasome Inhibitor Therapy
*Purpose: Patients sensitized to HLA antigens by prior transplantation, pregnancy or blood transfusion may have markedly prolonged waiting times for transplant. Moreover, once transplanted, the…2020 American Transplant Congress
Liver Transplant Recipients with High DSA at Time of Transplant Do Not Have Increased Rejection or Mortality
*Purpose: Currently, there is controversy regarding transplanting livers in setting of high HLA-class ll DSA especially since prior studies demonstrated enhanced acute rejections in this…2020 American Transplant Congress
Influence of Human Leukocyte Antigen Status and Gender of Positive Crossmatch Patients on Long-Term Survival Outcomes of Antibody Incompatible Renal Transplantation
*Purpose: Human Leukocyte Antigen (HLA) sensitization is a significant obstacle which limits the use of renal transplantation, but it serves as a therapeutic option for…2020 American Transplant Congress
Significance of DSA Clearance in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients on 1 Year Outcomes: Interim Results from PARAMOUr “Pediatric Renal AMr Outcomes” Study
*Purpose: Little is known about how donor specific antibody (DSA) clearance correlates with outcomes in pediatric antibody mediated rejection (AMR). There is also little data…2020 American Transplant Congress
Quantitative Analysis of Humoral Immunity by Flow-Cytometric Crossmatch Using Molecules of Equivalent Soluble Fluorochromosome (FCXM-MESF)
*Purpose: In this study, we examined the quantitative significance of humoral immunity by flow-cytometric crossmatch using molecules of equivalent soluble fluorochromosome (FCXM-MESF) in recipients of…2020 American Transplant Congress
HLA-DR/DQ Molecular Mismatch Dictates Early Risk of De Novo Donor-Specific Antibody Development and Offers a Personalized Approach to Immunosuppression Management in Kidney Transplantation
*Purpose: Clinicians have few tools to predict the risk of alloimmune injury in a patient undergoing renal transplantation, as traditional demographic or clinical variables lack…2020 American Transplant Congress
HLA Diversity Affects Epitope Mismatch Cutoffs Utilized to Predict De Novo DSA Development and Graft Rejection in Renal Transplant Patients
*Purpose: Recent studies have investigated epitope matching in order to determine its predictive power in determining renal transplant outcomes, both in terms of de novo…2020 American Transplant Congress
Failure to Launch; a Multi-Centre Study of Potential Live Donors in Southeast Nigeria
*Purpose: To determine the socio-demographic characteristics of potential living kidney donors, donor motivation, incidental findings on clinical evaluation and some identified factors that precluded eventual…2020 American Transplant Congress
HLA-Antibody Develops Preferentially in Healthy Subjects with a T-bethiB Cell Response to Vaccine
University of Alabama, Birmingham, AL
*Purpose: Bystander B cell differentiation into antibody (Ab) secreting cells (ASCs) may augment alloimmunity in the HLA-sensitized patient. Recently, a population of FcrL5+IgDnegB cells that…2020 American Transplant Congress
The Impact of a Positive Crossmatch on KAS Patients and Organs
1Medical Affairs, Hansa Biopharma, Camas, WA, 2Hansa Biopharma, Lund, Sweden, 3UNOS, Richmond, VA
*Purpose: Evaluate the potential effects of offer refusals due to positive crossmatch (+XM) on both patients and re-allocated organs with a focus on waitlist outcomes,…
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