2021 American Transplant Congress
Disparities in HLA Representation by Single Antigen Reagents in Different Ethnic Populations
1Keck School of Medicine of USC, Los Angeles, CA, 2Children's Hospital Los Angeles, Los Angeles, CA
*Purpose: It is not possible to test for antibodies against the antigens encoded by every HLA allele due to cost and throughput constraints. When alleles…2021 American Transplant Congress
Donor-specific Anti-HLA Alloantibody in Kidney Transplant Recipients with COVID-19 Exhibit a Different Immunoglobulin Class and Subclass Profile When Compared to Anti-SARS-CoV-2 Antibodies
*Purpose: Both anti-HLA and anti-SARS-CoV-2 antibodies target protein antigens. The aim of the present study was to compare the class and subclass profile of such…2021 American Transplant Congress
Desensitization Using Clazakizumab® (anti-il-6) in Highly-hla Sensitized Patients Awaiting Kidney Transplant (nct03380962)
*Purpose: IL-6 is a critical cytokine for plasma cell IgG production. Clazakizumab (CSL Behring LLC) is a humanized monoclonal aimed at the cytokine IL-6. Here…2021 American Transplant Congress
The Impact of Maintenance Immunosuppression Withdrawal on Sensitization Status After Renal Graft Failure
SUNY Upstate Medical University, Syracuse, NY
*Purpose: Maintaining immunosuppression (IS) following failed renal transplant may lead to increased risk for infections and malignancies; on the other hand, withdrawal can lead to…2021 American Transplant Congress
Guiding Therapeutic Plasma Exchange for Amr Treatment in Lung Transplant Recipients Using Serial Dilution in Single Antigen Bead Assay
*Purpose: Development of donor‐specific antibodies (DSA) is associated with poor outcomes in lung transplantation. Patients who are presented with at least probable AMR require treatment;…2021 American Transplant Congress
Outcomes of HLA Antibody Surveillance Protocol in Heart Transplant Patients – A Single-Center Retrospective Analysis
Baylor University Medical Center, Dallas, TX
*Purpose: Post-transplant care is multifaceted with protocols to provide oversight and maintain the standard of care. While institutional protocols for post-transplant HLA antibody surveillance after…2021 American Transplant Congress
Association Between HLA Class II and TLR4 Regulates HLA-II Stimulated P-selectin Expression and Monocyte Capture to Endothelial Cells
Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA
*Purpose: Antibody-mediated rejection (AMR) is a major obstacle for long-term allograft survival. Donor specific HLA antibodies (DSA) contribute to the process of AMR by binding…2021 American Transplant Congress
Calcineurin Inhibitor Dose and Selection, Not Antiproliferatives or Steroids, Influence Development of DSA One Year Post-kidney Transplant
*Purpose: Allograft rejection is a serious complication in kidney transplantation (KT). Despite advances in immunosuppression, acute rejection remains a concern in the first year of…2021 American Transplant Congress
Are All DSA’s the Same? Are We Ready for Precision Medicine in Pediatric LT?
*Purpose: Donor-specific antibodies (DSA) play an uncertain role in rejection after liver transplantation (LT). We hypothesized that evaluation of epitope differences in HLA-DR/DQ mismatching can…2021 American Transplant Congress
Sharp Anti-HLA Antibody Development Due to Concomitant Graft Nephrectomy and Immunosuppression Withdrawal After Early Graft Loss
*Purpose: The number of patients awaiting for retransplantation has been progressively increasing. The presence of anti-HLA antibodies can significantly lengthen the waiting time, limiting the…
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