ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "HLA antibodies"

  • 2022 American Transplant Congress

    Simultaneous Liver/ Kidney Transplant Reduces Both Donor Specific and Non-Donor Specific HLA Antibodies

    X. Zhang, S. Wisel, I. Kim, S. Jordan

    Cedars Sinai Medical Center, Los Angeles, CA

    *Purpose: Kidney allografts can be transplanted across strong donor specific antibody (DSA) barriers in simultaneous liver/kidney transplant (SLK) recipients. It is suggested that preformed DSAs…
  • 2022 American Transplant Congress

    Multicenter Effort Assessing the Effects of COVID Infection and Vaccination on HLA Antibodies in Waitlisted Patients with ESRD

    G. R. Roll1, M. Cooper2, H. Gebel3, K. M. Hitchman4, M. Hobeika5, J. Houp6, M. Kamoun7, J. Killian8, J. Kim9, V. Kumar10, M. Levine11, T. Lunow-Luke1, R. Parsons12, D. Ranch13, P. Stock14, S. Yi15, R. Rajalingam16

    1UCSF Medical Center, San Francisco, CA, 2MedStar Georgetown Transplant Institute, Washington, DC, 3Emory University Hospital, Atlanta, GA, 4Pathology and Laboratory Medicine, University of Texas Health San Antonio, San Antonio, TX, 5Houston Methodist, Houston, TX, 6University of Alabama, Birmingham, AL, 7Hospital Univ of Pennsylvania, Philadelphia, PA, 8University of Alabama at Birmingham, Birmingham, AL, 9Surgery, Keck Medicine of USC, Los Angeles, CA, 10University of Alabama at Birmingham Hospital, Birmingham, AL, 11University of Pennsylvania, Philadelphia, Pe, 12Emory University School of Medicine, Atlanta, GA, 13UT Health San Antonio, San Antonio, TX, 14Univ of California-San Francisco, San Francisco, CA, 15Houston Methodist Hospital, Houston, TX, 16Immunogenetics and Transplantation Laboratory (ITL), San Francisco, CA

    *Purpose: Although rare, infection and vaccination have been reported to result in human leukocyte antibodies (HLA). We analyzed the effect of SARS-CoV2 infection, or COVID-19…
  • 2022 American Transplant Congress

    Desensitization Protocol Consisting of High-Dose Intravenous Immunoglobulin, Plasmapheresis, and Rituximab in Highly Sensitized Kidney Transplant Recipients

    M. Okada, T. Hiramitsu, T. Tomosugi, K. Futamura, S. Narumi, N. Goto, Y. Watarai

    Nagoya Daini Red Cross Hospital, Nagoya, Japan

    *Purpose: In HLA incompatible kidney transplantation, donor-specific HLA antibody often causes antibody-mediated rejection (AMR). To prevent AMR, we adopted a preoperative desensitization protocol including high-dose…
  • 2022 American Transplant Congress

    HLA-Specific IgD/CD27 Double Negative B Cell Frequency Assessed by a Novel Multiplex Bead-Based Assay Predicts Rejection in Kidney Transplant Recipients

    Z. Ilyas1, A. Akl2, D. Pinelli1, L. Gallon3, A. Tambur1, M. Ansari4

    1Northwestern University, Chicago, IL, 2Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia, 3Northwestern Univ NMFF, Chicago, IL, 4Medicine, Northwestern University, Chicago, IL

    *Purpose: Recipients with sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) or Donor-specific anti-HLA antibodies (DSA) are at higher immunologic…
  • 2022 American Transplant Congress

    Establishment of an In Vitro Assay to Evaluate Indirect T-cell Allo-Response Using Donor PBMC-Pulsed Dendritic Cells

    K. Iwasaki1, T. Tomosugi2, T. Sekiya3, H. Hamana4, Y. Miwa1, K. Futamura2, M. Okada2, T. Hiramitsu2, N. Goto2, S. Narumi2, Y. Watarai2, H. Kishi4, M. Okumura5, S. Ashimine5, K. Ishiyama5, T. Kobayashi5

    1Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan, 2Department of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 3Department of Immune Regulation, The Research Center for Hepatitis and Immunology, Ichikawa, Japan, 4Department of Immunology, University of Toyama, Toyama, Japan, 5Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan

    *Purpose: Conventional MLR-based methods which evaluate donor-specific immune response via direct T-cell recognition pathway have been reported to be useful in predicting acute TCMR. However,…
  • 2022 American Transplant Congress

    A Novel Approach to Non-Invasive Multimodality Testing with Allosure and Allomap Predicts Microvascular Inflammation with High Accuracy in Kidney Transplant Recipients

    S. Parajuli, F. Aziz, N. Garg, S. E. Panzer, K. Van Hyfte, K. Degner, S. Reese, L. Ptak, N. Wilson, A. Djamali

    University of Wisconsin, Madison, WI

    *Purpose: The most prominent histologic lesion in antibody-mediated rejection (ABMR) is microvascular inflammation (MVI); however, its recognition and scoring can be challenging and poorly reproducible…
  • 2022 American Transplant Congress

    The Correlation of Dd-cfdna and Donor Specific Antibodies in Kidney Transplant Recipients

    S. Kant, T. Ishaque, A. Massie, D. C. Brennan, M. Bettinotti

    Johns Hopkins Hospital, Baltimore, MD

    *Purpose: Donor derived cell free DNA (dd-cfDNA) is increasingly being utilized to discern the presence of rejection in kidney transplant recipients (KTRs). There continues to…
  • 2022 American Transplant Congress

    Monitoring of Kidney Allograft Rejection Using Patient-Centric State-of-the-Art Tools – An Approach to Early Diagnosis and Intervention

    A. Rizvi1, A. Gamilla-Crudo2, S. A. Hussain3, M. Kueht4, J. Fair4, M. Mujtaba2

    1Internal Medicine, Nephrology, University of Texas Medical Branch, Galveston, TX, 2University of Texas Medical Branch, Galveston, TX, 3Nephrology, University of Texas Medical Branch, Houston, TX, 4Surgery, University of Texas Medical Branch, Galveston, TX

    *Purpose: The early detection and timely management of kidney allograft rejection using traditional markers including serum creatinine (SCr) has been inadequate due to lagging response.…
  • 2022 American Transplant Congress

    Prospective Analysis of the Impact of Impella 5.5 Devices on HLA Antibody Development in Transplant Recipients

    K. Castro, J. Van Zyl, R. Doss, S. McKean, J. Russelia, A. Alam, M. Askar, S. Hall

    Heart and lung Transplant Research, Baylor University Medical Center, Dallas, TX

    *Purpose: Little is known about the development of Human Leukocyte Antigen antibodies with the use of the new Impella 5.5 temporary mechanical circulatory assist device.*Methods:…
  • 2022 American Transplant Congress

    Elevated Donor-Derived Cell-Free DNA (dd-cfDNA) in the Early Post-Transplant Period is Associated with an Increased Incidence of Adverse Clinical Outcomes in Kidney Transplant Recipients

    D. Wojciechowski1, A. Patel2, S. Anand3, J. Klein4, A. Paramesh5, P. Sood6, G. Shekhtman7, N. Agrawal7, M. Fei7, K. Qu7, D. C. Brennan8

    1University of Texas, Southwestern, Dallas, TX, 2Saint Barnabas Medical Center, Livingston, NJ, 3Intermountain Healthcare, Murray, UT, 4University of Kansas Medical Center, Kansas City, KS, 5Tulane University School of Medicine, New Orleans, LA, 6University of Pittsburgh Medical Center, Pittsburgh, PA, 7CareDx, Brisbane, CA, 8Johns Hopkins School of Medicine, Baltimore, MD

    *Purpose: Early post-transplant elevations in dd-cfDNA, even in the absence of histologic rejection or other overt pathology, have been suggested to carry a risk of…
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