2022 American Transplant Congress
Prospective Analysis of the Impact of Impella 5.5 Devices on HLA Antibody Development in Transplant Recipients
Heart and lung Transplant Research, Baylor University Medical Center, Dallas, TX
*Purpose: Little is known about the development of Human Leukocyte Antigen antibodies with the use of the new Impella 5.5 temporary mechanical circulatory assist device.*Methods:…2022 American Transplant Congress
Elevated Donor-Derived Cell-Free DNA (dd-cfDNA) in the Early Post-Transplant Period is Associated with an Increased Incidence of Adverse Clinical Outcomes in Kidney Transplant Recipients
*Purpose: Early post-transplant elevations in dd-cfDNA, even in the absence of histologic rejection or other overt pathology, have been suggested to carry a risk of…2022 American Transplant Congress
De Novo DSA in the Setting of Stable Allograft Function is a Benign Finding
Houston Methodist Hospital, Houston, TX
*Purpose: We sought to determine the long-term outcome of renal allografts that developed de novo DSA (dnDSA) in the setting of stable renal function.*Methods: A…2022 American Transplant Congress
Use The Vascularized Sentinel Skin Flap For Prophylaxis Of Antibody-mediated Rejection After Kidney Transplantation In Highly Sensitized Patients
*Purpose: Patients with high titer of preexisting donor specific anti-HLA antibodies (DSA) have very high risk of antibody mediated rejection development and followed by the…2022 American Transplant Congress
Association Between De Novo Donor Specific Antibody and Tacrolimus Trough Levels in Long Term Follow Up Renal Transplantation
*Purpose: In this study, we aimed to identify the risk factors contributing to the development of donor-specific anti-HLA antibody (DSA) during long-term follow-up of patients…2022 American Transplant Congress
LGALS1 is Expressed in Glomerular Endothelial Cells and Induced Upon Stimulation with Anti-HLA Antibody
*Purpose: Antibody-mediated rejection (AMR) accounts for >50% of premature kidney graft loss. AMR is caused by donor specific antibodies (DSA) against human leukocyte antigens (HLA)…2022 American Transplant Congress
High Incidence Of Anti-HLA DSA And Late Allograft Dysfunction In Solid Organ Transplant Recipients Hospitalized With Covid-19
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Solid organ transplant (SOT) recipients admitted for COVID-19 commonly experience immunosuppression reduction and acute allograft dysfunction. Given the number of SOT patients hospitalized for…2022 American Transplant Congress
Utility of Four-Point Mycophenolate Mofetil Testing in a Pediatric Kidney Transplant Population
Pediatric Nephrology, UCSF, San Francisco, CA
*Purpose: While there is randomized, multicenter data in adults that area under the time concentration curve (AUC) measurements for Mycophenolate Mofetil (MMF) can direct dosing…2022 American Transplant Congress
De Novo Donor-Specific Antibody Development with Mycophenolate versus Azathioprine in Lung Transplant Recipients
*Purpose: The effect of mycophenolate mofetil (MMF) or azathioprine (AZA) immunosuppression (ISN) regimens on de novo donor specific antibody (DSA) formation in lung transplant recipients…2022 American Transplant Congress
Site-Directed Mutagenesis as a Tool to Investigate Immunogenicity of HLA Epitopes for Humoral Alloreactivity
1Northwestern University, Chicago, IL, 2University Hospital Essen, Essen, Germany
*Purpose: Molecular mismatch load (MML) analysis has been a proposed approach to assess donor/recipient compatibility in support of organ allocation algorithms. While conceptually appealing, MML…
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