ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "HLA antibodies"

  • 2016 American Transplant Congress

    Tocilizumab as Treatment for Persistent Chronic Active Antibody Mediated Rejection.

    H. Fernandez, S. Patel, M. Chiles, L. Ratner, R. Crew.

    Columbia University Medical Center, NYC.

    Intro: CAAMR is an increasingly recognized cause of renal allograft failure with limited treatment options. Many patients with CAAMR have engagement of both T and…
  • 2016 American Transplant Congress

    Donor Specif Antibody (DSA) Kinetics in Patients with Antibody Mediated Rejection (AMR) Treated with Plasmapheresis and Bortezomib.

    L. Requião-Moura,1 M. Afonso,2 A. Sakashita,3 M. Silva,1 A. Matos,1 A. Pacheco-Silva.1

    1Kidney Transplant, Hospital Israelita Albert Einstein, São Paulo, Brazil; 2Histocompatibility Laboratory, Hospital Israelita Albert Einstein, São Paulo, Brazil; 3Blood Bank, Hospital Israelita Albert Einstein, São Paulo, Brazil.

    Backgroud: The best choice to treat AMR is not supported by several evidences, and recently the interest in drugs as Bortezomib has improved. Aim: Evaluted…
  • 2016 American Transplant Congress

    Incidence and Factors Associated with De Novo DSA After BK Viremia in Renal Transplant Recipients.

    S. Patel, S. Kuten, R. Knight, D. Nguyen, E. Graviss, A. Gaber.

    Houston Methodist Hospital, Houston, TX.

    Recent literature indicates an elevated rate of de novo DSA (dnDSA) following BK viremia (BKV) in renal transplant recipients (RTR). We sought to review our…
  • 2015 American Transplant Congress

    Impact of Pretransplant Pregnancy On Immunization and Immunologic Outcome in Kidney Transplantation

    O. Staeck,1 D. Khadzhynov,1 S. Kreimer,1 E. Rajakangas,1 C. Schönemann,2 N. Lachmann,2 K. Budde,1 F. Halleck.1

    1Nephrology, Charité Universitätsmedizin, Berlin, Germany; 2Zentrum für Transfusionsmedizin, Charité Universitätsmedizin, Berlin, Germany.

    BACKGROUND:The detailed impact of pretransplant pregnancy on HLA alloimmunization and outcome after kidney transplantation is so far not well known.PATIENTS AND METHODS:A retrospective single center…
  • 2015 American Transplant Congress

    Pre-Transplant Donor Specific Antibody With Negative Flow-Crossmatch Was Related to Higher Acute Rejection But Not to Poor Graft Survival

    A. Guichard-Romero, L. Marino-Vazquez, M. Lopez, N. Castelan, A. De-Santiago, N. Uribe-Uribe, J. Alberu, L. Morales-Buenrostro.

    Nephrology, Transplantation, and Pathology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.

    Background: DSA have been associated to lower graft survival and a higher humoral rejection rate, but there is a concern about the clinical impact of…
  • 2015 American Transplant Congress

    First Clinical Data With an Improved C1q-Luminex® Assay

    A. Roodenburg,2 J. Bamoulid,1 O. Staeck,1 C. Schoenemann,2 N. Lachmann,2 K. Budde.1

    1Nephrology, Charite Hospital, Berlin, Germany; 2HLA Laboratory, Charite Hospital, Berlin, Germany.

    Background: Chronic allograft dysfunction remains the main obstacle for long-term success of kidney transplantation. Immunological factors, in particular HLA-antibodies, contribute to long-term allograft loss. Identification…
  • 2015 American Transplant Congress

    Accurate Prediction of High-Resolution HLA-A, -B, -C, -DRB1 and -DQB1 Typing and Low-Resolution HLA-DQA1 Typing by Haplotype Analysis

    A. Jaramillo,1 R. Vaidya,2 M. Pando,3 S. Gaitonde.4

    1Histocompatibility & Immunogenetics Laboratory, Gift of Hope Organ & Tissue Donor Network, Itasca, IL; 2College of Pharmacy, Roseman University of Health Sciences, South Jordan, UT; 3Department of Laboratory Medicine & Pathology, Mayo Clinic, Phoenix, AZ; 4Department of Pathology, University of Illinois, Chicago, IL.

    Aim: Allele-specific HLA antibodies are commonly detected by Luminex single antigen bead assays in solid organ transplant recipients. However, high-resolution HLA typing for deceased donors…
  • 2015 American Transplant Congress

    Donor-Specific Alloantibody After Positive Crossmatch Kidney Transplantation With Eculizumab (EC): Correlation With Transplant Glomerulopathy and Graft Failure

    C. Schinstock,1 F. Cosio,1 L. Cornell,1 M. Gandhi,1 M. Everly,2 M. Stegall.1

    1Mayo Clinic, Rochester, MN; 2Paul Terasaki Foundation, Los Angeles, CA.

    Introduction. EC (C5 blockade) reduces the incidence of early clinical acute antibody mediated rejection (AMR) after +XMKTx, but does not prevent chronic AMR. We examined…
  • 2015 American Transplant Congress

    Improved Long-Term Graft Survival in Renal Transplant Recipients With Donor Specific Antibodies (DSA) After Mycophenolic Acid Escalation

    L. Rebellato,1 K. Parker,2 F. Rana,3 S. Kendrick,4 C. Morgan,5 C. Haisch,5 M. Everly,6 R. Harland,5 P. Bolin.3

    1Pathology and Laboratory Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; 2Vidant Medical Center, Greenville, NC; 3Internal Medicine, East Carolina University, Brody School of Medicine, Greenville, NC; 4Eastern Nephrology Associates, Greenville, NC; 5Surgical Immunology and Transplantation, East Carolina University, Brody School of Medicine, Greenville, NC; 6Terasaki Foundation, Los Angeles, CA.

    Background: DSA formation in post-renal transplant patients is associated with chronic rejection and graft failure. Previous studies in our population indicate DSA formation is a…
  • 2015 American Transplant Congress

    Cyclophosphamide as a Salvage Therapy for Combined Intravenous Immunoglobulins and Plasmapheresis Refractory Antibody-Mediated Rejection

    W. Habhab,1 A. Dada,2 M. Alwassia,1 N. Baz,2 N. Zabani,1 A. Fahmy,1 A. Abdul Malik.1

    1Nephrology, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia; 2Pathlogy, King Faisal Specialist Hospital and Research Center, Jeddah, Saudi Arabia.

    Acute antibody-mediated rejection (AMR) poses a significant risk to graft survival. Current or standard treatment (ST) of AMR currently consists of plasmapheresis (PP), intravenous immunoglobulin…
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