ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "HLA antibodies"

  • 2016 American Transplant Congress

    Prospective Single Antigen Bead Epitope-Based Clustering for Early Detection of Antibody Mediated Rejection.

    A. Lichvar, S. Tremblay, P. Brailey, A. Girnita, R. Alloway, E. Woodle.

    U of Cincinnati, Cincinnati.

    Purpose:Epitope-based groups of HLA single antigen beads (SAB) often demonstrate clustering in patients with donor specific antibodies (DSA). Coordinated Mean Florescent Intensity (MFI) increases of…
  • 2016 American Transplant Congress

    The Combined Effect of Acute Rejection and De Novo Donor-Specific Antibodies on Kidney Allograft Survival.

    S. Davis, J. Gralla, A. Wiseman, J. Cooper.

    Division of Renal Diseases and Hypertension, University of Colorado, Aurora, CO.

    While dnDSA is associated with graft loss in multiple studies, the clinical context in which dnDSA develops and contributes to graft loss is less well…
  • 2016 American Transplant Congress

    Should HLA DR and DQ Eplet Mismatching Replace Traditional DR and DQ Mismatching for Deceased Donor Offers in Pediatric Renal Transplantation?

    C. Bryan, V. Chadha, B. Warady.

    Midwest Transplant Network, Kansas City, KS; Nephrology, Childrens Mercy Hospital, Kansas City, MO; Nephrology, Childrens Mercy Hospital, Kansas City, MO.

    Introduction. It is now appreciated that greater HLA DR mismatching of the first pediatric kidney transplantation is associated with higher degrees of sensitization, lower rates…
  • 2015 American Transplant Congress

    Assessment of Circulating HLA-Specific Alloreactive Memory B Cells Reveals Surreptitious Immunized Kidney Transplant Recipients at High Risk of Antibody-Mediated Rejection

    M. Lúcia,1 S. Luque,1 E. Crespo,1 J. Cruzado,1,2 E. Melilli,2 J. Martorell,3 J. Torras,1,2 S. Gil-Vernet,2 J. Grinyo,1,2 O. Bestard.1,2

    1Renal transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Catalunya, Spain; 2Experimental Nephrology Laboratory, IDIBELL, Barcelona, Catalunya, Spain; 3Histocompatibility Unit, Immunology Department, Hospital Clinic, Barcelona, Catalunya, Spain.

    Even though current bead-based multiplex techniques enable an accurate assessment of circulating HLA-specific antibodies, a more comprehensive study of the humoral alloimmune response through the…
  • 2015 American Transplant Congress

    DQB1 Epitope Matching Predicts the Development of De Novo DSA and Antibody Mediated Rejection

    M. Willicombe,1 M. Blow,2 P. Brookes,2 E. Santos,2 D. Taube.1

    1Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, United Kingdom; 2H&I, Hammersmith Hospital, London, United Kingdom.

    HLA DQ antibodies are the commonest de novo [DN] DSA specificity seen post renal transplantation. Their presence is associated with antibody mediated injury and allograft…
  • 2015 American Transplant Congress

    Measuring Affinity of Polyclonal HLA-Specific Antibodies in Highly Sensitised Cases Can Serve as an Additional Biomarker to Guide Direct Transplantation

    S. Daga,1,2 D. Lowe,6 R. Buchli,3 J. Collard,3 A. Mulder,8 C. McMurtrey,3,4 H. Moyse,7 N. Evans,7 N. Krishnan,2 W. Hildebrand,3,4 F. Claas,8 D. Briggs,5 D. Zehnder,1,2 D. Mithcell,1 R. Higgins.1,2

    1Clinical Sciences Research Laboratories, University of Warwick, Coventry, United Kingdom; 2Renal Unit, University Hospital, Coventry and Warwickshire NHS Trust, Coventry, United Kingdom; 3Pure Protein LLC, Oklahoma; 4University of Oklahoma Health Science Center, Oklahoma City; 5Department of Histocompatibility and Immunogenetics, NHS Blood and Transplant, Birmingham, United Kingdom; 6Department of Histocompatibility and Immunogenetics, Royal Liverpool University Hospital, Liverpool, United Kingdom; 7School of Engineering, University of Warwick, Coventry, United Kingdom; 8Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, Netherlands.

    Significant numbers of patients on transplant waiting lists in the UK are sensitised (43%). Direct transplantation across these HLA-specific antibodies using risk stratification strategies are…
  • 2015 American Transplant Congress

    The Correlation Between Donor Specific Antibodies and Heart Transplant Rejection

    R. Bedard,1 P. Jindra,2 M. Manson,1 M. Moaddab,1 H. Mallidi,3 W. Etheridge,1 A. Civitello,3 R. Kerman.2

    1CHI St. Luke's Health - Baylor St. Luke's Medical Center, Houston, TX; 2Immune Evaluation Laboratory, Baylor College of Medicine, Houston, TX; 3Texas Heart Institute, Baylor College of Medicine, Houston, TX.

    The presence of donor specific HLA antibodies (DSA) has been shown to be detrimental to heart transplant (HTx) survival. Virtual crossmatching (VXM) offers a rapid…
  • 2015 American Transplant Congress

    Risk of HLA Antibody Sensitization in Pediatric Heart Failure Patients Pre/Post Berlin VAD Procedure and Pre/Post Heart Transplantation

    R. Kerman, P. Jindra, A. Jeewa, S. Burki, C. Fraser, I. Adachi.

    Baylor College of Medicine, Houston, TX; Texas Children's Hospital, Houston, TX.

    The Berlin Heart Excor Ventricular Assist Device (Berlin VAD) was designed for use in children with heart failure. The Berlin VAD has allowed for successful…
  • 2015 American Transplant Congress

    Number of Antigen Targets: A Key Parameter for Accurate Flow Cytometry Crossmatch Interpretation of Weak DSA

    L. Hidalgo,1 S. Hasenbank,1 A. Halpin,1 P. Campbell.1,2

    1Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; 2Medicine, University of Alberta, Edmonton, AB, Canada.

    BACKGROUND: Flow cytometry crossmatch (FCXM) results are used to assess the safety of a transplant across pre-existing DSA. The number of targets on donor cells…
  • 2015 American Transplant Congress

    Improving the Predictive Value of the Virtual Crossmatch: Is the C1Q Assay Needed?

    A. Colovai,1 C. Savchik,1 P. Masiakos,1 S. Calp-Inal,2 L. Kayler,3 E. Akalin.2

    1Transplant Immunology Laboratory, Montefiore Medical Center, Bronx, NY; 2Nephrology, Montefiore Medical Center, Bronx, NY; 3Surgery, Montefiore Medical Center, Bronx, NY.

    The criteria for reporting unacceptable HLA antigens of renal transplant candidates differ greatly between transplant centers. In the attempt to refine these criteria, the experience…
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