Articles tagged "HLA antibodies"

2022 American Transplant Congress
De Novo DSA in the Setting of Stable Allograft Function is a Benign Finding
R. J. Knight, E. A. Graviss, D. T. Nguyen, T. N. Eagar, S. G. Yi, H. Podder, M. Hobeika, R. McMillan, A. O. Gaber
Houston Methodist Hospital, Houston, TX
*Purpose: We sought to determine the long-term outcome of renal allografts that developed de novo DSA (dnDSA) in the setting of stable renal function.*Methods: A…
2022 American Transplant Congress
Use The Vascularized Sentinel Skin Flap For Prophylaxis Of Antibody-mediated Rejection After Kidney Transplantation In Highly Sensitized Patients
A. Kalachyk, A. Nosik, D. Sadouski, H. Startsava
Nephrology, RRT and Kidney Transplant Unit, Minsk scientific and practical center for surgery, transplantation and hematology, State institution, MInsk, Belarus
*Purpose: Patients with high titer of preexisting donor specific anti-HLA antibodies (DSA) have very high risk of antibody mediated rejection development and followed by the…
2022 American Transplant Congress
Association Between De Novo Donor Specific Antibody and Tacrolimus Trough Levels in Long Term Follow Up Renal Transplantation
N. Fujiyama¹, M. Saito², R. Yamamoto², R. Sagehashi², T. Saito², Y. Aoyama², K. Numakura², T. Habuchi², S. Satoh¹
¹Center for Kidney Disease and Transplantation, Akita University Hospital, Akita, Japan, ²Department of Urology, Akita University Graduate School of Medicine, Akita, Japan
*Purpose: In this study, we aimed to identify the risk factors contributing to the development of donor-specific anti-HLA antibody (DSA) during long-term follow-up of patients…
2021 American Transplant Congress
Guiding Therapeutic Plasma Exchange for Amr Treatment in Lung Transplant Recipients Using Serial Dilution in Single Antigen Bead Assay
O. A. Timofeeva¹, J. Choe², M. Alsammak², E. J. Yoon², S. Geier², K. Carney², J. Au², A. Diamond², J. A. Galli², K. Shenoy², A. Mamary², S. Seghal², P. Mullhal², Y. Toyoda², N. Shigemura², F. Cordova², G. Criner², J. Brown²
¹MedStar Georgetown University Hospital, Washington, DC, ²Temple University Hospital, Philadelphia, PA
*Purpose: Development of donor‐specific antibodies (DSA) is associated with poor outcomes in lung transplantation. Patients who are presented with at least probable AMR require treatment;…
2021 American Transplant Congress
Outcomes of HLA Antibody Surveillance Protocol in Heart Transplant Patients – A Single-Center Retrospective Analysis
S. S. Patlolla, V. Bhattad, S. McKean, M. Askar, S. Hall
Baylor University Medical Center, Dallas, TX
*Purpose: Post-transplant care is multifaceted with protocols to provide oversight and maintain the standard of care. While institutional protocols for post-transplant HLA antibody surveillance after…
2021 American Transplant Congress
Association Between HLA Class II and TLR4 Regulates HLA-II Stimulated P-selectin Expression and Monocyte Capture to Endothelial Cells
Y. Jin, J. Nevarez-Mejia, E. F. Reed
Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA
*Purpose: Antibody-mediated rejection (AMR) is a major obstacle for long-term allograft survival. Donor specific HLA antibodies (DSA) contribute to the process of AMR by binding…
2021 American Transplant Congress
Calcineurin Inhibitor Dose and Selection, Not Antiproliferatives or Steroids, Influence Development of DSA One Year Post-kidney Transplant
M. Henderson¹, G. Morris², L. Awdishu¹, K. Fabbri¹, M. Shah³, A. Khan³, J. Kerr¹
¹Pharmacy, University of California San Diego Health, San Diego, CA, ²Pathology, University of California San Diego Health, San Diego, CA, ³Nephrology, University of California San Diego Health, San Diego, CA
*Purpose: Allograft rejection is a serious complication in kidney transplantation (KT). Despite advances in immunosuppression, acute rejection remains a concern in the first year of…
2021 American Transplant Congress
Are All DSA’s the Same? Are We Ready for Precision Medicine in Pediatric LT?
S. E. Shin¹, M. Lee¹, N. Yazigi², K. Khan², S. Kaufman², J. Ahn³, O. Timofeeva⁴, U. Ekong²
¹Georgetown University School of Medicine, Washington, DC, ²Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC, ³Biostatistics, Bioinformatics, & Biomathematics, Georgetown University, Washington, DC, ⁴Histocompatibility Laboratory, Dept. of Pathology & Laboratory Medicine, Georgetown University, Washington, DC
*Purpose: Donor-specific antibodies (DSA) play an uncertain role in rejection after liver transplantation (LT). We hypothesized that evaluation of epitope differences in HLA-DR/DQ mismatching can…
2021 American Transplant Congress
Sharp Anti-HLA Antibody Development Due to Concomitant Graft Nephrectomy and Immunosuppression Withdrawal After Early Graft Loss
R. Valero¹, A. Aguilera¹, E. Rodrigo¹, D. San Segundo², M. Lopez-Hoyos², J. Ruiz¹
¹Nefrología, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ²Inmunología, Hospital Universitario Marqués de Valdecilla, Santander, Spain
*Purpose: The number of patients awaiting for retransplantation has been progressively increasing. The presence of anti-HLA antibodies can significantly lengthen the waiting time, limiting the…
2021 American Transplant Congress
Investigating the HLA Alloimmune Background of the Histological Changes Suggestive of Antibody-mediated Injury in the Absence of Donor-specific Anti-HLA Antibodies
A. Senev, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: The histology of antibody-mediated rejection is observed frequently after kidney transplantation, but a significant percentage of the patients do not have detectable donor-specific HLA…