Articles tagged "HLA antibodies"

2018 American Transplant Congress
The Impact of Lymphocele Formation after Kidney Transplantation on De Novo Donor Specific Antibody Formation
L. Lehner, A. Hohberger, F. Halleck, E. Schrezenmeier, K. Budde, O. Staeck, D. Khadzhynov.
Dept. of Nephrology and Medical Intensive Care, Charité Universtitätsmedizin Berlin, Berlin, Germany.
Introduction: Lymphocele formation is a common complication after kidney transplantation and has been linked to rejection episodes. However, long-term outcome data are scarce and the…
2018 American Transplant Congress
Role of C1q-Binding Donor-Specific Anti-HLA Antibodies in Premature and Accelerated Kidney Allograft Interstitial Fibrosis
K. Louis, D. Viglietti, O. Aubert, A. Loupy, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France.
The 2017 Banff meeting has focused on the importance of a precise diagnosis of IF/TA in kidney recipients by addressing specific etiological factors. Recent studies…
2018 American Transplant Congress
Waning Enthusiasm for a Once Promising Test: C1q Testing Does Not Provide Prognostic Information for DSA Screening Protocols
A. Gilbert, D. Li, M. Awwad, S. Rosen-Bronson, P. Abrams, J. Verbesey, G. Vranic, M. Cooper.
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
Introduction: Testing of donor specific antibodies (DSA) for binding of complement component C1q has been used to better elucidate pathologic antibodies from more benign reactions.…
2018 American Transplant Congress
Pre-Transplant Memory Patients Even without Detected Antibody Are at Rejection Risk in the First-Year after Heart Transplantation
J. Patel, M. Kittleson, E. Kransdorf, R. Levine, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Patients (pts) with prior transplants, blood transfusions, and pregnancies awaiting heart transplantation (HTx) have potential to develop circulating anti-HLA antibodies (HLA Abs). Pts at…
2018 American Transplant Congress
Single Center Experience of HLA-Related Donor Specific Antibody in Living Donor Liver Transplantation
H. Egawa,¹ Y. Kotera,¹ A. Ohmori,¹ S. Yamashita,¹ T. Kato,¹ S. Nemoto,¹ T. Ishizuka,² M. Yamamoto.¹
¹Surgery, Tokyo Women's Medical University, Tokyo, Japan; ²Clinical Laboratory, Tokyo Women's Medical University, Tokyo, Japan.
Although impact of donor specific antibody in liver transplantation has been recognized, significance of desensitization is not established yet. Our aim is to share our…
2018 American Transplant Congress
Carfilzomib and Belatacept Reduces DSA and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation
B. Ezekian, J. Kwun, P. Schroder, M. Manook, J. Yoon, M. Mulvihill, K. Freischlag, J. Cochran, K. Kroning, J. Yi, S. Knechtle.
Duke Transplant Center, Duke University Medical Center, Durham, NC.
Purpose:Sensitized kidney transplant (KT) recipients have poor access to transplantation and inferior outcomes when transplanted. Conventional methods of desensitization remove donor specific antibody (DSA) temporarily,…
2018 American Transplant Congress
A Low Level of De Novo DSA Sialylation is Associated with a Decreased of Allograft Survival in Non-Sensitized Kidney Transplant Recipients
M. Bonnet,^1,2 V. Pernin,^1,3 J-.E. Serre,¹ V. Georgescu,⁴ M. Le Quintrec,^1,2,3 G. Mourad,^1,2 J-.F. Eliaou,^2,5 C. Rene.^2,5
¹Nephrology, Dialysis and Transplantation, Hôpital Lapeyronie, Montpellier University Hospital, Montpellier, France; ²University of Medicine, Montpellier University, Montpellier, France; ³Inserm U1183, IRMB, Hôpital Saint Eloi, Montpellier University Hospital, Montpellier, France; ⁴Department of Medical Information, Montpellier University Hospital, Montpellier, France; ⁵Department of Immunology, Hôpital Saint Eloi, Montpellier University Hospital, Montpellier, France.
Background. In kidney transplantation, de novo donor specific antibodies (dnDSA) are associated with antibody-mediated rejection (ABMR) and graft failure. While appearance of dnDSA, there is…
2018 American Transplant Congress
Serum Treatment with Fetal Bovine Serum Significantly Increases Luminex-Based HLA Antibody Assay Specificity by Reducing Heterophile Antibody Interference
A. Jaramillo,¹ J. House,¹ L. Nelson,¹ S. Stoll,¹ R. Ridgley,¹ H. Khamash.²
¹Department of Laboratory Medicine and Pathology, Mayo Clinic, Phoenix, AZ; ²Department of Medicine, Mayo Clinic, Phoenix, AZ.
Mean fluorescence intensity (MFI) values obtained from Luminex-based HLA antibody assays are used to determine the relative strength of HLA antibodies. However, MFI values can…
2018 American Transplant Congress
MCS and Desensitization
J. Kobashigawa, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, E. Passano, L. Czer, J. Moriguchi, F. Arabia.
Cedars Sinai Medical Center, Los Angeles.
Purpose: Sensitization prior to heart transplantation (HTx) has been associated with increased mortality and rates of rejection as well as an increased incidence of cardiac…
2018 American Transplant Congress
Long Term Culture of Functional Bone Marrow-Derived Human Plasma Cells
N. Moore, K. Bonner, M. D'Costa, M. Stegall.
William J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.
Introduction Antibody-secreting plasma cells (PCs) are critically important for host defense, but also can cause antibody-mediated allograft rejection. The ability to study these cells is…