Articles tagged "HLA antibodies"

2022 American Transplant Congress
Three-Way Comparison of Central DSA, %dd-cf DNA, and Molecular Biopsy Findings in the Trifecta Study
P. F. Halloran¹, L. G. Hidalgo², Z. Demko³, A. Prewett³, J. Reeve¹, C. Lawrence⁴, D. Lowe⁴, P. Billings³, .. and the Trifecta Investigators⁵
¹Alberta Transplant Applied Genomics Centre, Edmonton AB, AB, Canada, ²University of Wisconsin, Madison, WI, ³Natera Inc., San Carlos, CA, ⁴One Lambda Inc., West Hills, CA, ⁵., ., AB, Canada
*Purpose: Trifecta (ClinicalTrials.gov #NCT04239703) is a prospective, IRB-approved, consented study of the relationships among three central tests in kidney transplant indication biopsies: molecular biopsy diagnoses…
2022 American Transplant Congress
Clazakizumab® (anti-il-6) Desensitization in Highly-HLA Sensitized Patients Awaiting Kidney Transplant (nct03380962): Long-Term Follow Up
A. Vo¹, J. Tang¹, N. Ammerman¹, E. Huang¹, X. Zhang², M. Haas³, A. Peng¹, R. Najjar¹, S. Williamson¹, C. Meyers¹, S. Sethi¹, K. Lim¹, M. Gillespie¹, N. Badash¹, S. Jordan¹
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ²HLA Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA, ³Pathology, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6 is a cytokine critical for B-cell activation and IgG production. Clazakizumab (CSL Behring LLC) is a humanized monoclonal aimed at the cytokine IL-6.…
2022 American Transplant Congress
Outcomes of a Standardized Antibody-Mediated Rejection (AMR) Treatment Protocol in Heart Transplant Recipients (HTR)
J. Lee, T. Sam, J. Van Zyl, S. Mckean, L. Fuller, N. Wilson, A. Dao, R. Gottlieb, S. Hall, R. Patel
Baylor University Medical Center, Dallas, TX
*Purpose: AMR in HTR portends poor clinical outcomes. Reported mortality range between 20-50%, with higher rates reported for late AMR occurring at least 1 year…
2022 American Transplant Congress
Dynamic Changes of Serum Soluble B Cell Activating Factor in Kidney Transplant with De Novo Donor Specific Antibody
S. Wu¹, X. Su¹, Y. Gao¹, Y. Wei¹, Q. Ye¹, M. Huang², Y. Chen¹, J. Wang¹, Q. Zhang³, Q. Fu¹, J. Li², H. Huang², B. Xu², H. Zhang¹, L. Liu², C. Wang²
¹Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, ²The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, ³Charité - Universitätsmedizin Berlin, Berlin, Germany
*Purpose: De novo donor specific antibody (dnDSA) plays a crucial role in the development of antibody mediated rejection (ABMR) and is correlated to the worse…
2022 American Transplant Congress
Simultaneous Liver/ Kidney Transplant Reduces Both Donor Specific and Non-Donor Specific HLA Antibodies
X. Zhang, S. Wisel, I. Kim, S. Jordan
Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: Kidney allografts can be transplanted across strong donor specific antibody (DSA) barriers in simultaneous liver/kidney transplant (SLK) recipients. It is suggested that preformed DSAs…
2022 American Transplant Congress
Multicenter Effort Assessing the Effects of COVID Infection and Vaccination on HLA Antibodies in Waitlisted Patients with ESRD
G. R. Roll¹, M. Cooper², H. Gebel³, K. M. Hitchman⁴, M. Hobeika⁵, J. Houp⁶, M. Kamoun⁷, J. Killian⁸, J. Kim⁹, V. Kumar¹⁰, M. Levine¹¹, T. Lunow-Luke¹, R. Parsons¹², D. Ranch¹³, P. Stock¹⁴, S. Yi¹⁵, R. Rajalingam¹⁶
¹UCSF Medical Center, San Francisco, CA, ²MedStar Georgetown Transplant Institute, Washington, DC, ³Emory University Hospital, Atlanta, GA, ⁴Pathology and Laboratory Medicine, University of Texas Health San Antonio, San Antonio, TX, ⁵Houston Methodist, Houston, TX, ⁶University of Alabama, Birmingham, AL, ⁷Hospital Univ of Pennsylvania, Philadelphia, PA, ⁸University of Alabama at Birmingham, Birmingham, AL, ⁹Surgery, Keck Medicine of USC, Los Angeles, CA, ¹⁰University of Alabama at Birmingham Hospital, Birmingham, AL, ¹¹University of Pennsylvania, Philadelphia, Pe, ¹²Emory University School of Medicine, Atlanta, GA, ¹³UT Health San Antonio, San Antonio, TX, ¹⁴Univ of California-San Francisco, San Francisco, CA, ¹⁵Houston Methodist Hospital, Houston, TX, ¹⁶Immunogenetics and Transplantation Laboratory (ITL), San Francisco, CA
*Purpose: Although rare, infection and vaccination have been reported to result in human leukocyte antibodies (HLA). We analyzed the effect of SARS-CoV2 infection, or COVID-19…
2022 American Transplant Congress
Desensitization Protocol Consisting of High-Dose Intravenous Immunoglobulin, Plasmapheresis, and Rituximab in Highly Sensitized Kidney Transplant Recipients
M. Okada, T. Hiramitsu, T. Tomosugi, K. Futamura, S. Narumi, N. Goto, Y. Watarai
Nagoya Daini Red Cross Hospital, Nagoya, Japan
*Purpose: In HLA incompatible kidney transplantation, donor-specific HLA antibody often causes antibody-mediated rejection (AMR). To prevent AMR, we adopted a preoperative desensitization protocol including high-dose…
2022 American Transplant Congress
HLA-Specific IgD/CD27 Double Negative B Cell Frequency Assessed by a Novel Multiplex Bead-Based Assay Predicts Rejection in Kidney Transplant Recipients
Z. Ilyas¹, A. Akl², D. Pinelli¹, L. Gallon³, A. Tambur¹, M. Ansari⁴
¹Northwestern University, Chicago, IL, ²Dr. Soliman Fakeeh Hospital, Jeddah, Saudi Arabia, ³Northwestern Univ NMFF, Chicago, IL, ⁴Medicine, Northwestern University, Chicago, IL
*Purpose: Recipients with sensitization to HLA defined by a high percentage of Panel Reactive Antibodies (PRA) or Donor-specific anti-HLA antibodies (DSA) are at higher immunologic…
2022 American Transplant Congress
Establishment of an In Vitro Assay to Evaluate Indirect T-cell Allo-Response Using Donor PBMC-Pulsed Dendritic Cells
K. Iwasaki¹, T. Tomosugi², T. Sekiya³, H. Hamana⁴, Y. Miwa¹, K. Futamura², M. Okada², T. Hiramitsu², N. Goto², S. Narumi², Y. Watarai², H. Kishi⁴, M. Okumura⁵, S. Ashimine⁵, K. Ishiyama⁵, T. Kobayashi⁵
¹Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan, ²Department of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, ³Department of Immune Regulation, The Research Center for Hepatitis and Immunology, Ichikawa, Japan, ⁴Department of Immunology, University of Toyama, Toyama, Japan, ⁵Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan
*Purpose: Conventional MLR-based methods which evaluate donor-specific immune response via direct T-cell recognition pathway have been reported to be useful in predicting acute TCMR. However,…
2022 American Transplant Congress
A Novel Approach to Non-Invasive Multimodality Testing with Allosure and Allomap Predicts Microvascular Inflammation with High Accuracy in Kidney Transplant Recipients
S. Parajuli, F. Aziz, N. Garg, S. E. Panzer, K. Van Hyfte, K. Degner, S. Reese, L. Ptak, N. Wilson, A. Djamali
University of Wisconsin, Madison, WI
*Purpose: The most prominent histologic lesion in antibody-mediated rejection (ABMR) is microvascular inflammation (MVI); however, its recognition and scoring can be challenging and poorly reproducible…

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