ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "HLA antibodies"

  • 2022 American Transplant Congress

    Establishment of an In Vitro Assay to Evaluate Indirect T-cell Allo-Response Using Donor PBMC-Pulsed Dendritic Cells

    K. Iwasaki1, T. Tomosugi2, T. Sekiya3, H. Hamana4, Y. Miwa1, K. Futamura2, M. Okada2, T. Hiramitsu2, N. Goto2, S. Narumi2, Y. Watarai2, H. Kishi4, M. Okumura5, S. Ashimine5, K. Ishiyama5, T. Kobayashi5

    1Department of Kidney Diseases and Transplant Immunology, Aichi Medical University School of Medicine, Nagakute, Japan, 2Department of Transplant Surgery, Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan, 3Department of Immune Regulation, The Research Center for Hepatitis and Immunology, Ichikawa, Japan, 4Department of Immunology, University of Toyama, Toyama, Japan, 5Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Japan

    *Purpose: Conventional MLR-based methods which evaluate donor-specific immune response via direct T-cell recognition pathway have been reported to be useful in predicting acute TCMR. However,…
  • 2022 American Transplant Congress

    A Novel Approach to Non-Invasive Multimodality Testing with Allosure and Allomap Predicts Microvascular Inflammation with High Accuracy in Kidney Transplant Recipients

    S. Parajuli, F. Aziz, N. Garg, S. E. Panzer, K. Van Hyfte, K. Degner, S. Reese, L. Ptak, N. Wilson, A. Djamali

    University of Wisconsin, Madison, WI

    *Purpose: The most prominent histologic lesion in antibody-mediated rejection (ABMR) is microvascular inflammation (MVI); however, its recognition and scoring can be challenging and poorly reproducible…
  • 2022 American Transplant Congress

    The Correlation of Dd-cfdna and Donor Specific Antibodies in Kidney Transplant Recipients

    S. Kant, T. Ishaque, A. Massie, D. C. Brennan, M. Bettinotti

    Johns Hopkins Hospital, Baltimore, MD

    *Purpose: Donor derived cell free DNA (dd-cfDNA) is increasingly being utilized to discern the presence of rejection in kidney transplant recipients (KTRs). There continues to…
  • 2022 American Transplant Congress

    Monitoring of Kidney Allograft Rejection Using Patient-Centric State-of-the-Art Tools – An Approach to Early Diagnosis and Intervention

    A. Rizvi1, A. Gamilla-Crudo2, S. A. Hussain3, M. Kueht4, J. Fair4, M. Mujtaba2

    1Internal Medicine, Nephrology, University of Texas Medical Branch, Galveston, TX, 2University of Texas Medical Branch, Galveston, TX, 3Nephrology, University of Texas Medical Branch, Houston, TX, 4Surgery, University of Texas Medical Branch, Galveston, TX

    *Purpose: The early detection and timely management of kidney allograft rejection using traditional markers including serum creatinine (SCr) has been inadequate due to lagging response.…
  • 2022 American Transplant Congress

    Prospective Analysis of the Impact of Impella 5.5 Devices on HLA Antibody Development in Transplant Recipients

    K. Castro, J. Van Zyl, R. Doss, S. McKean, J. Russelia, A. Alam, M. Askar, S. Hall

    Heart and lung Transplant Research, Baylor University Medical Center, Dallas, TX

    *Purpose: Little is known about the development of Human Leukocyte Antigen antibodies with the use of the new Impella 5.5 temporary mechanical circulatory assist device.*Methods:…
  • 2022 American Transplant Congress

    Elevated Donor-Derived Cell-Free DNA (dd-cfDNA) in the Early Post-Transplant Period is Associated with an Increased Incidence of Adverse Clinical Outcomes in Kidney Transplant Recipients

    D. Wojciechowski1, A. Patel2, S. Anand3, J. Klein4, A. Paramesh5, P. Sood6, G. Shekhtman7, N. Agrawal7, M. Fei7, K. Qu7, D. C. Brennan8

    1University of Texas, Southwestern, Dallas, TX, 2Saint Barnabas Medical Center, Livingston, NJ, 3Intermountain Healthcare, Murray, UT, 4University of Kansas Medical Center, Kansas City, KS, 5Tulane University School of Medicine, New Orleans, LA, 6University of Pittsburgh Medical Center, Pittsburgh, PA, 7CareDx, Brisbane, CA, 8Johns Hopkins School of Medicine, Baltimore, MD

    *Purpose: Early post-transplant elevations in dd-cfDNA, even in the absence of histologic rejection or other overt pathology, have been suggested to carry a risk of…
  • 2022 American Transplant Congress

    De Novo DSA in the Setting of Stable Allograft Function is a Benign Finding

    R. J. Knight, E. A. Graviss, D. T. Nguyen, T. N. Eagar, S. G. Yi, H. Podder, M. Hobeika, R. McMillan, A. O. Gaber

    Houston Methodist Hospital, Houston, TX

    *Purpose: We sought to determine the long-term outcome of renal allografts that developed de novo DSA (dnDSA) in the setting of stable renal function.*Methods: A…
  • 2022 American Transplant Congress

    Use The Vascularized Sentinel Skin Flap For Prophylaxis Of Antibody-mediated Rejection After Kidney Transplantation In Highly Sensitized Patients

    A. Kalachyk, A. Nosik, D. Sadouski, H. Startsava

    Nephrology, RRT and Kidney Transplant Unit, Minsk scientific and practical center for surgery, transplantation and hematology, State institution, MInsk, Belarus

    *Purpose: Patients with high titer of preexisting donor specific anti-HLA antibodies (DSA) have very high risk of antibody mediated rejection development and followed by the…
  • 2022 American Transplant Congress

    Association Between De Novo Donor Specific Antibody and Tacrolimus Trough Levels in Long Term Follow Up Renal Transplantation

    N. Fujiyama1, M. Saito2, R. Yamamoto2, R. Sagehashi2, T. Saito2, Y. Aoyama2, K. Numakura2, T. Habuchi2, S. Satoh1

    1Center for Kidney Disease and Transplantation, Akita University Hospital, Akita, Japan, 2Department of Urology, Akita University Graduate School of Medicine, Akita, Japan

    *Purpose: In this study, we aimed to identify the risk factors contributing to the development of donor-specific anti-HLA antibody (DSA) during long-term follow-up of patients…
  • 2022 American Transplant Congress

    LGALS1 is Expressed in Glomerular Endothelial Cells and Induced Upon Stimulation with Anti-HLA Antibody

    A. Boshart1, S. Farkona1, S. Clotet-Freixas1, C. McEvoy1, J. Murphy1, S. Crome2, A. Konvalinka3

    1Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada, 2Immunology, Toronto General Hospital Research Institute, Ajmera Transplant Centre, University of Toronto, University Health Network, Toronto, ON, Canada, 3Nephrology, Toronto General Hospital Research Institute, Ajmera Transplant Centre, University Health Network, Toronto, ON, Canada

    *Purpose: Antibody-mediated rejection (AMR) accounts for >50% of premature kidney graft loss. AMR is caused by donor specific antibodies (DSA) against human leukocyte antigens (HLA)…
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