2017 American Transplant Congress
Long-Term Immunosuppression Adherence After Kidney Transplant and Relationship to Allograft Histology.
Background: Loss of Medicare coverage for immunosuppression 3 years after kidney transplant may be associated with increased nonadherence. The goal of this study was to…2017 American Transplant Congress
Clinical and Pathologic Characteristics of Acute Rejection After Alemtuzumab Induction in Kidney Transplant Recipients.
Background: Alemtuzumab induction (AZI) can be used for early steroid withdrawal in kidney transplant (KTx) recipients. There is evidence that AZI-induced lymphocyte depletion leads to…2017 American Transplant Congress
Digital Image Analysis of Pediatric Liver Allograft Biopsies Correlates with METAVIR Fibrosis Score.
1Children's Mercy Hospital, Kansas City, MO; 2University of Kansas Medical Center, Kansas City, KS
Background: Serial surveillance biopsies demonstrate post-transplant inflammation and fibrosis in long-surviving pediatric liver allografts. These changes can ultimately lead to cirrhosis and graft failure. However,…2017 American Transplant Congress
Biodistribution of Adipose Derived Regenerative Cells Administered via the Renal Artery in Novel Rat Transplant Model.
Introduction:A novel rodent model of ischaemia- reperfusion injury (IRI) has shown significant improvement in renal function and histology after administration of adipose derived regenerative cells…2017 American Transplant Congress
The Impact of Early Clinical and Subclinical T Cell Rejection After Kidney Transplantation.
Medicine and Surgery, University of Pittsburgh, Pittsburgh, PA
Purpose: To evaluate the impact of early Clinical(C-TCMR) and Sub-Clinical(SC-TCMR) T Cell Mediated Rejection on short-term allograft histology and function.Methods: We examined adult kidney alone…2017 American Transplant Congress
Subclinical Histologic Findings Are Observed in 25% of Stable Adult Liver Transplant Recipients (ALTRs) Screened for Immunosuppression Withdrawal (ISW): OPTIMAL (NCT02533180).
OPTIMAL is a 6-center ISW study in non-autoimmune, non-HCV ALTRs ≥3 yrs post-transplant (tx). Studies have shown a correlation between portal inflammation associated with tissue…2017 American Transplant Congress
Compartmental Infiltration of Kidney Allograft with Monocyte-Macrophage Subtypes Defines the Type of Rejection.
Purpose: Rejection significantly worsens the graft function and survival. We studied monocyte-macrophage compartmental infiltration of 62 kidney transplant biopsies with diagnosis of: acute antibody mediated…2016 American Transplant Congress
Association of Ultrastructural Changes in Renal Allograft Biopsies with Antibody-Mediated Rejection (AMR) and Graft Outcomes.
The role of electron microscopy (EM) in diagnosis of AMR is not well-defined. We sought to examine the EM findings in 796 biopsies from 622…2016 American Transplant Congress
Kidney Structural Characteristics as Predictors of Long-Term Kidney Function in Living Kidney Donors.
PurposeKidney structural characteristics may be predictive of long-term living donor outcomes such as a lower estimated Glomerular Filtration Rate (eGFR).MethodsAs part of the Renal and…2016 American Transplant Congress
Natural Language Processing Methods Allow Reliable Extraction of Banff Scores and Grades.
Objective: National Data are sparse with regard to pathology of rejection. Incorporating biopsy pathology grades and lesion scores into analyses requires manual extraction and entry…
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