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American Transplant Congress abstracts

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Articles tagged "Histology"

  • 2022 American Transplant Congress

    Histopathology at Diagnosis and One-Year Outcomes in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients: Preliminary Findings from the Paramour “Pediatric Renal AMR Outcomes” Study

    R. Zahr1, D. Puliyanda2, I. Ashoor3, N. Hayde4, S. Solomon5, R. Engen6, L. Harshman7, C. Peterson8, S. McEwen9, A. Jain10, R. Garro11, A. Mansuri12, M. Kallash13, K. Twombley14

    1Pediatrics, University of Tennessee Health Science Center, Memphis, TN, 2Cedars-Sinai Med Ctr, West Hollywood, CA, 3Pediatrics, Lousiana State University, New Orleans, LA, 4Montefiore Medical Center, Bronx, NY, 5The Children's Hospital at Montefiore, New York, NY, 6Pediatrics, University of Wisconsin Madison, Madison, WI, 7University of Iowa Children's Hospital, Iowa City, IA, 8University of Utah, Salt Lake City, UT, 9University of Minnesota, Minneapolis, MN, 10Pediatrics, Wayne State University, Troy, MI, 11Emory University, Atlanta, GA, 12Pediatrics, Augusta University, Augusta, GA, 13Pediatrics, The Ohio State Univesrity, Columbus, OH, 14Medical University of South Carolina, Charleston, SC

    *Purpose: Antibody mediated rejection (AMR) is a major cause of kidney allograft dysfunction leading to graft loss. There is a paucity of data regarding how…
  • 2022 American Transplant Congress

    Pre-Transplant Evaluation of Patients Undergoing Combined Heart-Liver Transplantation and Correlation with Explant Pathology

    A. Shingina1, J. N. Menachem1, S. Brown1, I. A. Ziogas2, W. K. Wu3, M. J. Izzy4, J. Liang1, K. Washington1, S. Alexopoulos5

    1Vanderbilt University Medical Center, Nashville, TN, 2Division of Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN, 3Thoracic Surgery; Hepatobiliary Surgery and Liver Transplantation, Vanderbilt University Medical Center, Nashville, TN, 4GI and Hepatology, Vanderbilt University Medical Center, Nashville, TN, 5Vanderbilt Medical Center, Nashville, TN

    *Purpose: Fontan-associated liver disease (FALD) is a well-described complication of Fontan physiology. More patients with failing Fontan are being evaluated for heart transplant and evidence-based…
  • 2022 American Transplant Congress

    Single Cell Multiomics Reveals Immune Mediators in Acute Cellular Rejection Following Pediatric Liver Transplantation

    B. Rocque1, D. Sarode2, A. Barbetta3, P. Singh4, C. Goldbeck4, C. Weaver5, O. Akbari4, R. Kohli5, J. Emamaullee6

    1University of Southern California Keck School of Medicine, Los Angeles, CA, 2Keck School of Medicine of University of Southern California, Pasadena, CA, 3Surgery, abdominal transplat, University of Southern California, Los Angeles, CA, 4Keck School of Medicine of USC, Los Angeles, CA, 5Childrens Hospital Los Angeles, Los Angeles, CA, 6University of Southern California, Los Angeles, CA

    *Purpose: Acute cellular rejection (ACR) is a common complication following pediatric liver transplantation with potential negative effects on allograft longevity. Currently, diagnosis and management are…
  • 2022 American Transplant Congress

    Recoverability of Diabetic Nephropathy of Donor Kidney After Kidney Transplantation

    K. Lee, J. Park

    Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: The natural course of diabetic donors on the outcome of kidney transplantation (KT) is controversial. The aim of this study was to analyze the…
  • 2022 American Transplant Congress

    Enhanced Histological Yield and Actionable Findings When Biopsy is Guided by Donor-Derived Cell-Free DNA (dd-cfDNA)

    M. R. Weir1, D. Mandelbrot2, J. S. Bromberg1, S. Mehta3, E. Poggio4, E. Huang5, G. Shekhtman6, N. Agrawal7, W. Tian8, M. Cooper9

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Wisconsin, Madison, WI, 3University of Alabama, Birmingham, AL, 4Cleveland Clinic, Cleveland, OH, 5Cedars-Sinai Medical Center, Los Angeles, CA, 6CareDx Inc., Brisbane, CA, 7CareDx Inc, Brisbane, CA, 8CareDx, Brisbane, CA, 9MedStar Georgetown Transplant Institute, Washington, DC

    *Purpose: Implementation of molecular biomarkers in kidney transplantation has expanded the amount of information available to clinicians before deciding to pursue biopsy. We evaluated how…
  • 2022 American Transplant Congress

    Wide Spectrum of Molecular Injury Highlights Heterogeneity of Banff Tubulitis and Interstitial Inflammation Lesions

    M. J. Ellis1, T. Maw2, E. Huang3, E. Stites4, F. Shihab5, D. C. Brennan6, G. Shekhtman7, N. Agrawal7, J. Zeng7, S. Kung8

    1Duke University, Durham, NC, 2University of Southern California, Los Angeles, CA, 3Cedars-Sinai Medical Center, Los Angeles, CA, 4University of Colorado, Aurora, CO, 5University of Utah, Salt Lake City, UT, 6Johns Hopkins School of Medicine, Baltimore, MD, 7CareDx, Brisbane, CA, 8University of California, San Francisco, San Francisco, CA

    *Purpose: The pathological definition and clinical significance of borderline T cell-mediated rejection (BL-TCMR) remains an area of active debate, leading to inconsistencies in therapeutic strategy.…
  • 2022 American Transplant Congress

    A Model of Idiopathic Pneumonia Syndrome in Rhesus Macaques

    R. S. Bermea1, K. Ingersoll2, L. P. Hariri3, M. Warren2, L. Kean2, V. Tkachev2

    1Pulmonary & Critical Care Medicine, Massachusetts General Hospital, Boston, MA, 2Hematology/Oncology, Boston Children's Hospital, Boston, MA, 3Pathology, Massachusetts General Hospital, Boston, MA

    *Purpose: To create a model of idiopathic pneumonia syndrome (IPS), a deadly complication of hematopoietic stem cell transplantation (HSCT) in Rhesus macaques (RM).*Methods: RM were…
  • 2022 American Transplant Congress

    Acute Tubular Injury and Necrosis Do Not Lead to Meaningful Elevations in Donor-Derived Cell-Free DNA (dd-cfDNA)

    S. R. Allam1, M. Cooper2, D. Kumar3, T. Maw4, A. Wiseman5, P. Chuang6, G. Shekhtman7, N. Agrawal7, J. Zeng7, E. Huang8

    1Medical City Transplant Institute, Fort Worth, TX, 2Medstar Georgetown Transplant Institute, Washington, DC, 3Virginia Commonwealth University, Richmond, VA, 4University of Southern California, Los Angeles, CA, 5Centura Health, Denver, CO, 6Metrolina Nephrology, Charlotte, NC, 7CareDx, Brisbane, CA, 8Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Associations between non-rejection histologic diagnoses and dd-cfDNA have not been extensively characterized. We explored these associations in kidney transplant recipients enrolled in the Kidney…
  • 2022 American Transplant Congress

    Deceased Donor Procurement Biopsy Practices, Interpretation, and Histology-Based Decision Making: A Survey of US Transplant Centers

    V. Fleetwood1, D. Axelrod2, Y. Caliskan1, H. Randall1, J. Wellen3, M. Lichtenberger3, C. Dedert1, R. Rothweiler4, G. F. Marklin4, D. Brockmeier4, M. A. Schnitzler1, S. A. Husain5, S. Mohan5, B. Kasiske6, M. Cooper7, K. L. Lentine1

    1Saint Louis U., St. Louis, MO, 2U. of Iowa, Iowa City, IA, 3WUSTL, St. Louis, MO, 4Mid-Am. Trans., St. Louis, MO, 5Columbia U., New York, NY, 6Hennepin Healthcare, Minneapolis, MN, 7MedStar Transpl. Inst., Washington, DC

    *Purpose: In light of contemporary controversies on the utility of kidney procurement biopsies in predicting allograft outcomes and guiding organ acceptance, we surveyed transplant providers…
  • 2022 American Transplant Congress

    Discordant Histological Findings During Acute Rejection in a Combined Face and Hand Transplant Recipient

    O. C. Onuh1, J. Trilles1, W. J. Rifkin1, H. Brydges1, B. F. Chaya1, R. Rodriguez Colon1, D. Boczar1, D. J. Ceradini1, E. D. Rodriguez1, B. E. Gelb2

    1Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, 2Transplant Institute, NYU Langone Health, New York, NY

    *Purpose: The purpose of this study is to evaluate histologic findings in a face and bilateral hand transplant recipient that was monitored with multi-site allograft…
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