Articles tagged "Histocompatibility antigens"

2015 American Transplant Congress
Accurate Prediction of High-Resolution HLA-A, -B, -C, -DRB1 and -DQB1 Typing and Low-Resolution HLA-DQA1 Typing by Haplotype Analysis
A. Jaramillo,¹ R. Vaidya,² M. Pando,³ S. Gaitonde.⁴
¹Histocompatibility & Immunogenetics Laboratory, Gift of Hope Organ & Tissue Donor Network, Itasca, IL; ²College of Pharmacy, Roseman University of Health Sciences, South Jordan, UT; ³Department of Laboratory Medicine & Pathology, Mayo Clinic, Phoenix, AZ; ⁴Department of Pathology, University of Illinois, Chicago, IL.
Aim: Allele-specific HLA antibodies are commonly detected by Luminex single antigen bead assays in solid organ transplant recipients. However, high-resolution HLA typing for deceased donors…
2015 American Transplant Congress
HLA Matching Affects Patient Survival, Graft Survival, and Incidence of Rejection Episodes in Largest Analysis to Date
J. Weiner, Z. Cui, S. Mohan, E. Verna, A. Griesemer, J. Emond.
Columbia Center for Liver Disease and Transplantation, New York Presbyterian-Columbia University Medical Center, New York, NY.
Introduction: Though human leukocyte antigen (HLA) matching between donor and recipient affects both graft and patient survival after kidney and heart transplantation, prior analysis has…
2015 American Transplant Congress
Comparative Survival Benefits and Costs of an Eplet and Broad Antigen Based Matching System in Deceased Donor Kidney Transplant Allocation Among Indigenous Australians
H. Do Nguyen,¹ G. Wong,^2,3 J. Chapman,² J. Craig,^2,3 L. D'Orsogna,⁴ W. Lim.^1,5
¹School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia; ²Nephrology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia; ³School of Medicine, University of New South Wales, Sydney, New South Wales, Australia; ⁴Clinical Immunology, Royal Perth Hospital, Perth, Western Australia, Australia; ⁵Renal Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Aim: To compare the benefits and costs of incorporating an eplet-based matching algorithm to the current allocation of deceased donor kidneys to indigenous Australians.Background: The…
2015 American Transplant Congress
HLA Broad Antigen and Eplet Mismatches in Determining the Risk of Acute Rejection After Kidney Transplantation
H. Do Nguyen,¹ W. Lim,^1,2 J. Chapman,³ J. Craig,^3,4 G. Wong.^3,4
¹School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia; ²Renal Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia; ³Nephrology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia; ⁴School of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Aim: To determine the clinical relevance of HLA-ABDR broad antigen and eplet matching for predicting acute rejection after kidney transplantation.Background: HLAMatchmaker determines structurally HLA compatibility…