ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Histocompatibility antigens"

  • 2018 American Transplant Congress

    The Impact of Duration on Dialysis on the Pre-Transplant Allosensitization According to Panel Reactive Antibody Levels

    Y. Jung,1 D. Kim,1 J. Lee,1 S. Song,2 J. Lee,3 B. Kim,4 J. Lee,1 S. Kim,1 M. Kim,1 S. Kim,1 Y. Kim,1 K. Huh.1

    1Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea; 2Department of Surgery, College of Medicine, Ewha Women's University, Seoul, Republic of Korea; 3Department of Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea; 4Departments of Nephrology, Yonsei University College of Medicine, Seoul, Republic of Korea.

    Purpose : Presensitization to human leukocyte antigen(HLA) is one of the most important barriers to overcome in the field of renal transplantation. Due to the…
  • 2017 American Transplant Congress

    Using Buccal Swabs for Deceased Organ Donor HLA Typing.

    C. Muse,2 S. Longobardi,1 I. Gimferrer,1 J. Orlowski.2

    1HLA Laboratory, OU Medical Center, Oklahoma City, OK; 2LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK

    Aim: In some cases, getting enough cells from a deceased donor to perform crossmatches and DNA extraction for HLA typing is challenging. Specifically this is…
  • 2017 American Transplant Congress

    Immunosuppression and Graft Rejection in Living-Related HLA-Identical Renal Transplantation.

    R. Ossman,1 M. Jamme,1 P. Galichon,1 A. Hertig,1 B. Moulin,2 C. Legendre,3 E. Morelon,4 J.-L. Taupin,5 L. Rostaing,6 E. Rondeau.1

    1Urgences Néphrologiques et Transplantation, Hôpital Tenon, RADOVFULL Study Group, Université Pierre et Marie Curie, Paris, France; 2Néphrologie et Transplantation, Hôpital Civil, Strasbourg, France; 3Néphrologie et Transplantation, Hôpital Necker-Enfants Malades, Université Paris Descartes, Paris, France; 4Néphrologie et Transplantation, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; 5Laboratoire d'Histocompatibilité, Hôpital Saint-Louis, Université Paris Diderot, Paris, France; 6Néphrologie et Transplantation d'Organes, Université Paul Sabatier, Toulouse, France

    Purpose: We aimed to describe the immunosuppressive regimens and graft rejection rates in living-related HLA-identical (LR HLAid) renal transplantation.Methods: We performed a retrospective multicenter analysis…
  • 2017 American Transplant Congress

    HLA-DPA1 and HLA-DPB1 Frequencies in the US Populations.

    Z. Du, J. Patel, C. Braun, B. Norton.

    Pathology, Loyola University Medical Center, Maywood, IL

    Aim: HLA-DP antibodies can elicit positive crossmatches and be detrimental in organ transplantation. Although HLA-DP unacceptable antigens can be input in the UNOS database, they…
  • 2017 American Transplant Congress

    Pre-Transplant Non-Cytotoxic Donor Specific HLA Antibodies Do Not Increase the Risk of Graft Dysfunction in Kidney Transplant Recipients with Thymoglobulin and IVIG Induction.

    A. Colovai, M. Ajaimi, N. Hayde, L. Kamal, S. Chan, C. Savchik, J. Rocca, E. Akalin.

    Surgery, Montefiore Medical Center, Bronx, NY

    The aim of this study was to evaluate the impact of pre-formed donor specific HLA antibodies (DSA) in a large population of kidney transplant (tx)…
  • 2017 American Transplant Congress

    Correlation of Complement Activating Donor Specific Antibodies as Measured by C3d and Cross-Match Status.

    A. Babu,1,2,3 N. Krishnan,2 D. Briggs,3 D. Mitchell,1 S. Daga.1,2,4

    1Warwick Medical School, University of Warwick, Coventry, United Kingdom; 2Nephrology and Transplantation, University Hospitals Coventrya and Warwickshire, Coventry, United Kingdom; 3Histocompatibility and Immunogenetics, NHS Blood and Transfusion, Birmingham, United Kingdom; 4Nephrology and Transplantation, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom

    Introduction. Complement dependent cytotoxicity, first described in 1969 is the only functional assay studying complement activation. C3d assay is developed recently to study complement activation…
  • 2016 American Transplant Congress

    Donor Specific Antibody Used to Predict Crossmatch Results: A Clinically Useful Algorithm Derived from the College of American Pathologists Survey.

    S. Wrenn,1 D.-S. Hain,2 S. Harm,2 S. Hillyard,2 D. Shah,2 P. Hammond,2 C. Marroquin,1 M. Fung.2

    1Transplant Surgery, University of Vermont Medical Center, Burlington, VT; 2Pathology, University of Vermont Medical Center, Burlington, VT.

    Purpose: While there are multiple modalities to perform a preoperative crossmatch for organ transplant surgery, the cytotoxic crossmatch remains the gold standard for detection of…
  • 2015 American Transplant Congress

    HLA-Cw Mismatches Are Not Associated With Worse Graft Outcomes After Kidney Transplantation Even in High Levels of Antigen Expression

    M. Askar,1 N. Elfadawy,1,2 S. Flechner,1 K. Abu-Elmagd,1 J. Fung,1 J. Schold.1

    1Cleveland Clinic, Cleveland; 2University of Alexandria, Alexandria, Egypt.

    The HLA-Cw antigens are distinct in having relatively lower expression on the cell surface compared to the other HLA class I loci. Higher HLA Cw…
  • 2015 American Transplant Congress

    Reasons for Match Offer Refusals and Efforts to Reduce Them in the OPTN/UNOS Kidney Paired Donation Pilot Program (KPDPP)

    R. Leishman,1 D. Stewart,1 A. Kucheryavaya,1 L. Robbins Callahan,1 T. Sandholm,2 M. Aeder.3

    1UNOS, Richmond, VA; 2Carnegie Mellon Univ, Pittsburgh, PA; 3Univ Hosp Case Med Ctr, Cleveland, OH.

    Background: The OPTN/UNOS KPDPP has been finding 2-way, 3-way, and chain exchanges since Oct 2010. Though the number of pairs entered, matches found, and transplants…
  • 2015 American Transplant Congress

    Antibodies Directed Against HLA-DQ Are Significantly Associated to Complement Activation In Vitro

    J. Arreola-Guerra, A. de Santiago, A. Arvizu, N. Gonzalez-Tableros, M. Lopez, M. Vilatoba, L. Morales-Buenrostro, J. Alberu, N. Castelan.

    1Transplantation, 1aNephrology-Mineral Metabolism, Inst Nal de Ciencias Medicas y Nutricion SZ, Mexico City, Distrito Federal, Mexico.

    Background: C1q-binding HLA antibodies (HLAabs) have been related to acute rejection and long-term graft loss. The characteristics of these antibodies and factors associated to complement…
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