Articles tagged "Histocompatibility antigens"

2018 American Transplant Congress
The Impact of Duration on Dialysis on the Pre-Transplant Allosensitization According to Panel Reactive Antibody Levels
Y. Jung,¹ D. Kim,¹ J. Lee,¹ S. Song,² J. Lee,³ B. Kim,⁴ J. Lee,¹ S. Kim,¹ M. Kim,¹ S. Kim,¹ Y. Kim,¹ K. Huh.¹
¹Department of Surgery, Yonsei University College of Medicine, Seoul, Republic of Korea; ²Department of Surgery, College of Medicine, Ewha Women's University, Seoul, Republic of Korea; ³Department of Surgery, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea; ⁴Departments of Nephrology, Yonsei University College of Medicine, Seoul, Republic of Korea.
Purpose : Presensitization to human leukocyte antigen(HLA) is one of the most important barriers to overcome in the field of renal transplantation. Due to the…
2017 American Transplant Congress
Immunosuppression and Graft Rejection in Living-Related HLA-Identical Renal Transplantation.
R. Ossman,¹ M. Jamme,¹ P. Galichon,¹ A. Hertig,¹ B. Moulin,² C. Legendre,³ E. Morelon,⁴ J.-L. Taupin,⁵ L. Rostaing,⁶ E. Rondeau.¹
¹Urgences Néphrologiques et Transplantation, Hôpital Tenon, RADOVFULL Study Group, Université Pierre et Marie Curie, Paris, France; ²Néphrologie et Transplantation, Hôpital Civil, Strasbourg, France; ³Néphrologie et Transplantation, Hôpital Necker-Enfants Malades, Université Paris Descartes, Paris, France; ⁴Néphrologie et Transplantation, Hôpital Edouard Herriot, Université de Lyon, Lyon, France; ⁵Laboratoire d'Histocompatibilité, Hôpital Saint-Louis, Université Paris Diderot, Paris, France; ⁶Néphrologie et Transplantation d'Organes, Université Paul Sabatier, Toulouse, France
Purpose: We aimed to describe the immunosuppressive regimens and graft rejection rates in living-related HLA-identical (LR HLAid) renal transplantation.Methods: We performed a retrospective multicenter analysis…
2017 American Transplant Congress
HLA-DPA1 and HLA-DPB1 Frequencies in the US Populations.
Z. Du, J. Patel, C. Braun, B. Norton.
Pathology, Loyola University Medical Center, Maywood, IL
Aim: HLA-DP antibodies can elicit positive crossmatches and be detrimental in organ transplantation. Although HLA-DP unacceptable antigens can be input in the UNOS database, they…
2017 American Transplant Congress
Pre-Transplant Non-Cytotoxic Donor Specific HLA Antibodies Do Not Increase the Risk of Graft Dysfunction in Kidney Transplant Recipients with Thymoglobulin and IVIG Induction.
A. Colovai, M. Ajaimi, N. Hayde, L. Kamal, S. Chan, C. Savchik, J. Rocca, E. Akalin.
Surgery, Montefiore Medical Center, Bronx, NY
The aim of this study was to evaluate the impact of pre-formed donor specific HLA antibodies (DSA) in a large population of kidney transplant (tx)…
2017 American Transplant Congress
Correlation of Complement Activating Donor Specific Antibodies as Measured by C3d and Cross-Match Status.
A. Babu,^1,2,3 N. Krishnan,² D. Briggs,³ D. Mitchell,¹ S. Daga.^1,2,4
¹Warwick Medical School, University of Warwick, Coventry, United Kingdom; ²Nephrology and Transplantation, University Hospitals Coventrya and Warwickshire, Coventry, United Kingdom; ³Histocompatibility and Immunogenetics, NHS Blood and Transfusion, Birmingham, United Kingdom; ⁴Nephrology and Transplantation, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Introduction. Complement dependent cytotoxicity, first described in 1969 is the only functional assay studying complement activation. C3d assay is developed recently to study complement activation…
2017 American Transplant Congress
Using Buccal Swabs for Deceased Organ Donor HLA Typing.
C. Muse,² S. Longobardi,¹ I. Gimferrer,¹ J. Orlowski.²
¹HLA Laboratory, OU Medical Center, Oklahoma City, OK; ²LifeShare Transplant Donor Services of Oklahoma, Oklahoma City, OK
Aim: In some cases, getting enough cells from a deceased donor to perform crossmatches and DNA extraction for HLA typing is challenging. Specifically this is…
2016 American Transplant Congress
Donor Specific Antibody Used to Predict Crossmatch Results: A Clinically Useful Algorithm Derived from the College of American Pathologists Survey.
S. Wrenn,¹ D.-S. Hain,² S. Harm,² S. Hillyard,² D. Shah,² P. Hammond,² C. Marroquin,¹ M. Fung.²
¹Transplant Surgery, University of Vermont Medical Center, Burlington, VT; ²Pathology, University of Vermont Medical Center, Burlington, VT.
Purpose: While there are multiple modalities to perform a preoperative crossmatch for organ transplant surgery, the cytotoxic crossmatch remains the gold standard for detection of…
2015 American Transplant Congress
HLA Matching Affects Patient Survival, Graft Survival, and Incidence of Rejection Episodes in Largest Analysis to Date
J. Weiner, Z. Cui, S. Mohan, E. Verna, A. Griesemer, J. Emond.
Columbia Center for Liver Disease and Transplantation, New York Presbyterian-Columbia University Medical Center, New York, NY.
Introduction: Though human leukocyte antigen (HLA) matching between donor and recipient affects both graft and patient survival after kidney and heart transplantation, prior analysis has…
2015 American Transplant Congress
Comparative Survival Benefits and Costs of an Eplet and Broad Antigen Based Matching System in Deceased Donor Kidney Transplant Allocation Among Indigenous Australians
H. Do Nguyen,¹ G. Wong,^2,3 J. Chapman,² J. Craig,^2,3 L. D'Orsogna,⁴ W. Lim.^1,5
¹School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia; ²Nephrology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia; ³School of Medicine, University of New South Wales, Sydney, New South Wales, Australia; ⁴Clinical Immunology, Royal Perth Hospital, Perth, Western Australia, Australia; ⁵Renal Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia.
Aim: To compare the benefits and costs of incorporating an eplet-based matching algorithm to the current allocation of deceased donor kidneys to indigenous Australians.Background: The…
2015 American Transplant Congress
HLA Broad Antigen and Eplet Mismatches in Determining the Risk of Acute Rejection After Kidney Transplantation
H. Do Nguyen,¹ W. Lim,^1,2 J. Chapman,³ J. Craig,^3,4 G. Wong.^3,4
¹School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia; ²Renal Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia; ³Nephrology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia; ⁴School of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Aim: To determine the clinical relevance of HLA-ABDR broad antigen and eplet matching for predicting acute rejection after kidney transplantation.Background: HLAMatchmaker determines structurally HLA compatibility…