2022 American Transplant Congress
Optimization of Human Liver Organoid Model for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
*Purpose: The aim of our project is to develop an in vitro 3D human liver organoid (3D-HLO) model for studying nonalcoholic fatty liver disease (NAFLD)…2022 American Transplant Congress
CEACAM1 Splice Isoforms Are Regulated by Hypoxia Inducible Factors 1 alpha (HIF-1a) to Protect Against Ischemic Injury in Mouse and Human Liver Transplantation
*Purpose: CEACAM1 (CC1) is a transmembrane glycoprotein that undergoes extensive alternative splicing (AS) to generate CC1-S and CC1-L. It is currently unclear which of these…2022 American Transplant Congress
Hepatocyte SIRT1 Regulation of Apoptosis-Mediated Pyroptosis Cell Death in Mouse and Human Liver Transplantation
1UCLA Medical Center, Los Angeles, CA, 2NIEHS, Durham, NC
*Purpose: Cold static preservation is a gold-standard in orthotopic liver transplantation (OLT). However, the role of hepatocyte-specific SIRT1 transcriptional regulation of cell death programs during…2021 American Transplant Congress
Hepatocyte SIRT1 Suppresses Atf4-mediated Apoptosis Triggered by Cold Stress in Mouse and Human Liver Transplantation
1Dumont-UCLA Transplant Center, Los Angeles, CA, 2NIEHS, Durham, NC
*Purpose: The role of ER-stress or hepatocyte-specific SIRT1 signaling during donor liver cold preservation remains unknown. We employed a mouse OLT model and analyzed clinical…2021 American Transplant Congress
Invariant Nkt Cells Promote Expansion of Novel Cxcr3+Ccr4+Cd8+ T Cells in the Liver Following Allogeneic Hepatocyte Transplant
*Purpose: Hepatocyte transplantation represents a treatment for metabolic diseases and a bridge therapy to whole organ transplant but is limited in part by cell immunogenicity.…2021 American Transplant Congress
Ectopic Hepatocyte Transplantation Into the Lymph Nodes in a Fully Mismatched Allogeneic Dog Model Using Tacrolimus and Prednisone
*Purpose: Develop organogenesis through ectopic hepatocyte transplantation (HT) into the upper abdominal lymph nodes (LN).*Methods: Three groups of Mongrel dogs weighting between 25-35 kg (control…2020 American Transplant Congress
Identification of Novel Gene Targets Inducing Resistance in Liver Ischemia Reperfusion Injury by CRISPR Screening
*Purpose: Liver transplantation (LT) is the best treatment option for patients with end-stage liver disease (ESLD). However, the gap between available donors and recipients in…2020 American Transplant Congress
In a Murine Model of Acetaminophen-Mediated Liver Injury, Tubastatin-a, An Hdac6-Specific Inhibitor, Improves Survival and Decreases Hepatocellular Injury
*Purpose: Tylenol (APAP) toxicity, due to its narrow therapeutic window, is the leading cause of acute liver failure in the United States, resulting in approximately…2020 American Transplant Congress
Hepatocyte Growth Factor (HGF) Prevents the Apoptotic and Anti-Angiogenic Effect of Hypercholesterolemia on Hepatocytes in Liver Allografts
*Purpose: Background: Hypercholesterolemia (HC) impairs angiogenesis and induces apoptosis in livers. This hyperlipidemic impairment of angiogenesis reported associated with reduced bFGF. HGF stimulates proliferation, angiogenesis,…2020 American Transplant Congress
Multifactorial Effect of Hepatocyte Growth Factor (HGF) on the Microscopic Regeneration of Liver Allograft in Recipients Who Underwent Transplantation from Living Donors
*Purpose: Although partial liver allografts from living donors have near-complete regeneration of their liver volumes within weeks after transplantation, the microscopic range of regeneration is…
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