ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Hepatocytes"

  • 2020 American Transplant Congress

    Identification of Novel Gene Targets Inducing Resistance in Liver Ischemia Reperfusion Injury by CRISPR Screening

    C. Kuscu, A. R. Wolen, C. Kuscu, C. Watkins, A. Bajwa, J. D. Eason, D. Maluf, V. Mas

    Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Liver transplantation (LT) is the best treatment option for patients with end-stage liver disease (ESLD). However, the gap between available donors and recipients in…
  • 2020 American Transplant Congress

    In a Murine Model of Acetaminophen-Mediated Liver Injury, Tubastatin-a, An Hdac6-Specific Inhibitor, Improves Survival and Decreases Hepatocellular Injury

    C. S. OBrien1, P. T. Hernandez1, S. J. Concors1, L. N. Krumeich1, Z. Wang1, G. Ge1, T. Bhatti2, A. Kozikowski3, W. Hancock2, M. H. Levine1

    1Department of Surgery, University of Pennsylvania, Philadelphia, PA, 2Department of Pathology, Children's Hospital of Pennsylvania, Philadelphia, PA, 3Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL

    *Purpose: Tylenol (APAP) toxicity, due to its narrow therapeutic window, is the leading cause of acute liver failure in the United States, resulting in approximately…
  • 2020 American Transplant Congress

    Hepatocyte Growth Factor (HGF) Prevents the Apoptotic and Anti-Angiogenic Effect of Hypercholesterolemia on Hepatocytes in Liver Allografts

    H. B. Ozdemir1, G. Ozgun1, A. Yucel Polat1, N. Haberal1, G. Moray2, M. Haberal2

    1Pathology, Baskent University, Ankara, Turkey, 2Department of General Surgery, Division of Transplantation, Baskent University, Ankara, Turkey

    *Purpose: Background: Hypercholesterolemia (HC) impairs angiogenesis and induces apoptosis in livers. This hyperlipidemic impairment of angiogenesis reported associated with reduced bFGF. HGF stimulates proliferation, angiogenesis,…
  • 2020 American Transplant Congress

    Multifactorial Effect of Hepatocyte Growth Factor (HGF) on the Microscopic Regeneration of Liver Allograft in Recipients Who Underwent Transplantation from Living Donors

    B. H. Ozdemir1, G. Ozgun1, A. Yucel Polat1, M. Haberal2

    1Pathology, Baskent University, Ankara, Turkey, 2Department of General Surgery, Division of Transplantation, Baskent University, Ankara, Turkey

    *Purpose: Although partial liver allografts from living donors have near-complete regeneration of their liver volumes within weeks after transplantation, the microscopic range of regeneration is…
  • 2020 American Transplant Congress

    The Therapeutic Potential of Human Liver-Derived Stem Cells Transplantation in Carbon Tetrachloride-Induced Rat Liver Cirrhotic Model

    S. Lee1, J. Lee2, H. Park2, Y. Kim2, S. Lee1

    1Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, 2Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: Cirrhosis is a long-term consequence of chronic hepatic injury and there are no effective treatment methods. Mesenchymal stem cells (MSCs) have been reported to…
  • 2020 American Transplant Congress

    Epithelial To Mesenchymal Transition Mediates Engraftment Of Endoderm And Hepatic Progenitor Cells In The Quiescent Liver

    W. S. Fagg1, N. Lui2, L. Patrikeev3, O. Saldarriaga*4, H. Lerner-Stevenson5, V. Popov6, M. Motamade3, J. H. Fair1

    1Surgery, University of Texas Medical Branch, Galveston, TX, 2Surgery, Naiyou Lui, Galveston, TX, 3Ophthalmology, University of Texas Medical Branch, Galveston, TX, 4Pathology, Omar Saldarriaga, Galveston, TX, 5pathology, University of Texas Medical Branch, Galveston, TX, 6Pathology, University of Texas Medical Branch, Galveston, TX

    *Purpose: Stem cell transplantation to the liver is a promising therapeutic strategy for a variety of disorders. Hepatocyte transplantation has short term efficacy, but can…
  • 2020 American Transplant Congress

    Improved Survival of Acute Liver Failure by “Off-the-Shelf” Bioartificial Liver Support System Using Immobilized Cryopreserved Hepatocyte Spheroids in Porcine Model

    S. Lee1, J. Lee2, H. Park2, Y. Kim2, J. Noh3, J. Jung3, S. Lee3, H. Shin3, H. Yoon4, D. Lee3, S. Lee1

    1Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, 2Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of, 3Biomedical Research Center, Lifeliver, Co. Ltd., Yongin, Korea, Republic of, 4Biomedical Research Center, Lifeliver, Co. Ltd., Seoul, Korea, Republic of

    *Purpose: Acute liver failure (ALF) has a rapid and unpredictable onset with high mortality. The only current treatment is to transplant a donor organ but…
  • 2019 American Transplant Congress

    Hepatocyte SIRT1 Modulates ATF4/CHOP and Mitigates Liver Transplant Ischemia-Reperfusion Injury: From Bench-to-Bedside

    H. Hirao1, S. Kageyama1, K. Kadono1, K. Nakamura1, T. Ito1, K. J. Dery1, D. Oncel1, X. Li2, B. Ke1, F. M. Kaldas1, R. W. Busuttil1, J. W. Kupiec‐Weglinski1

    1Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA, 2National Institute of Environmental Health Sciences, Research Triangle Park, NC

    *Purpose: We and others have reported on benefits of endoplasmic reticulum (ER) stress modulation against hepatic ischemia-reperfusion injury (IRI) in orthotopic liver transplantation (OLT). Although…
  • 2019 American Transplant Congress

    Glycogen Synthase Kinase 3alpha Serine 21 Phosphorylation Inhibits Hepatocyte Autophagy to Facilitate Liver Ischemia Reperfusion Injury

    M. Ni1, H. Zhou2, R. Busuttil1, J. Kupiec-Weglinski1, X. Wang2, Y. Zhai1

    1Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, 2Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Glycogen synthase kinase 3 (Gsk3) has α and β isoforms. They are constitutively active in cells and inhibited upon stimulations by N-terminal serine phosphorylation.…
  • 2019 American Transplant Congress

    The Efficacy of Spheroidal Hepatocytes for Hepatocyte Transplantation

    K. Shibuya, M. Watanabe, Y. Ganchiku, R. Kanazawa, Y. Koshizuka, M. Zaitsu, R. Goto, A. Taketomi

    Department of Gastroenterological Surgery Ⅰ Hokkaido University Graduate School, Sapporo, Japan

    *Purpose: Hepatocyte transplantation (HCTx) is expected to expand its application as a next generation therapy alternative to liver transplantation. Following HCTx, the liver function improves…
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