ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Hepatocytes"

  • 2022 American Transplant Congress

    Optimization of Human Liver Organoid Model for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

    Y. Park1, D. Thadasina1, K. Isidan1, K. J. Lopez1, A. Cross-Najafi1, P. Li1, H. Francis2, G. Alpini2, W. Zhang1, B. Ekser1

    1Surgery, Indiana University School of Medicine, Indianapolis, IN, 2Division of Gastroenterology & Hepatology, Indiana University School of Medicine, Indianapolis, IN

    *Purpose: The aim of our project is to develop an in vitro 3D human liver organoid (3D-HLO) model for studying nonalcoholic fatty liver disease (NAFLD)…
  • 2022 American Transplant Congress

    CEACAM1 Splice Isoforms Are Regulated by Hypoxia Inducible Factors 1 alpha (HIF-1a) to Protect Against Ischemic Injury in Mouse and Human Liver Transplantation

    K. J. Dery1, H. Kojima1, K. Kadono2, H. Hirao1, J. Kupiec-Weglinski3

    1UCLA, Los Angeles, CA, 2Liver Transplant Surgery, UCLA, Los Angeles, CA, 3UCLA Medical Center, Los Angeles, CA

    *Purpose: CEACAM1 (CC1) is a transmembrane glycoprotein that undergoes extensive alternative splicing (AS) to generate CC1-S and CC1-L. It is currently unclear which of these…
  • 2022 American Transplant Congress

    Hepatocyte SIRT1 Regulation of Apoptosis-Mediated Pyroptosis Cell Death in Mouse and Human Liver Transplantation

    K. Kadono1, H. Hirao1, H. Kojima1, K. J. Dery1, X. Li2, J. Kupiec-Weglinski1

    1UCLA Medical Center, Los Angeles, CA, 2NIEHS, Durham, NC

    *Purpose: Cold static preservation is a gold-standard in orthotopic liver transplantation (OLT). However, the role of hepatocyte-specific SIRT1 transcriptional regulation of cell death programs during…
  • 2021 American Transplant Congress

    Invariant Nkt Cells Promote Expansion of Novel Cxcr3+Ccr4+Cd8+ T Cells in the Liver Following Allogeneic Hepatocyte Transplant

    J. Zimmerer1, B. Ringwald2, S. Chaudhari1, J. Han1, C. M. Peterson1, R. T. Warren1, M. Hart1, M. Abdel-Rasoul3, G. Bumgardner1

    1OSU, Columbus, OH, 2Medical Student Research Program, OSU, Columbus, OH, 3Center for Biostatistics, OSU, Columbus, OH

    *Purpose: Hepatocyte transplantation represents a treatment for metabolic diseases and a bridge therapy to whole organ transplant but is limited in part by cell immunogenicity.…
  • 2021 American Transplant Congress

    Ectopic Hepatocyte Transplantation Into the Lymph Nodes in a Fully Mismatched Allogeneic Dog Model Using Tacrolimus and Prednisone

    P. A. Fontes

    NA, LyGenesis, Pittsburgh, PA

    *Purpose: Develop organogenesis through ectopic hepatocyte transplantation (HT) into the upper abdominal lymph nodes (LN).*Methods: Three groups of Mongrel dogs weighting between 25-35 kg (control…
  • 2021 American Transplant Congress

    Hepatocyte SIRT1 Suppresses Atf4-mediated Apoptosis Triggered by Cold Stress in Mouse and Human Liver Transplantation

    K. Kadono1, H. Hirao1, H. Kojima1, K. J. Dery1, J. Aziz1, X. Li2, J. W. Kupiec-Weglinski1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2NIEHS, Durham, NC

    *Purpose: The role of ER-stress or hepatocyte-specific SIRT1 signaling during donor liver cold preservation remains unknown. We employed a mouse OLT model and analyzed clinical…
  • 2020 American Transplant Congress

    Identification of Novel Gene Targets Inducing Resistance in Liver Ischemia Reperfusion Injury by CRISPR Screening

    C. Kuscu, A. R. Wolen, C. Kuscu, C. Watkins, A. Bajwa, J. D. Eason, D. Maluf, V. Mas

    Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Liver transplantation (LT) is the best treatment option for patients with end-stage liver disease (ESLD). However, the gap between available donors and recipients in…
  • 2020 American Transplant Congress

    In a Murine Model of Acetaminophen-Mediated Liver Injury, Tubastatin-a, An Hdac6-Specific Inhibitor, Improves Survival and Decreases Hepatocellular Injury

    C. S. OBrien1, P. T. Hernandez1, S. J. Concors1, L. N. Krumeich1, Z. Wang1, G. Ge1, T. Bhatti2, A. Kozikowski3, W. Hancock2, M. H. Levine1

    1Department of Surgery, University of Pennsylvania, Philadelphia, PA, 2Department of Pathology, Children's Hospital of Pennsylvania, Philadelphia, PA, 3Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL

    *Purpose: Tylenol (APAP) toxicity, due to its narrow therapeutic window, is the leading cause of acute liver failure in the United States, resulting in approximately…
  • 2020 American Transplant Congress

    Hepatocyte Growth Factor (HGF) Prevents the Apoptotic and Anti-Angiogenic Effect of Hypercholesterolemia on Hepatocytes in Liver Allografts

    H. B. Ozdemir1, G. Ozgun1, A. Yucel Polat1, N. Haberal1, G. Moray2, M. Haberal2

    1Pathology, Baskent University, Ankara, Turkey, 2Department of General Surgery, Division of Transplantation, Baskent University, Ankara, Turkey

    *Purpose: Background: Hypercholesterolemia (HC) impairs angiogenesis and induces apoptosis in livers. This hyperlipidemic impairment of angiogenesis reported associated with reduced bFGF. HGF stimulates proliferation, angiogenesis,…
  • 2020 American Transplant Congress

    Multifactorial Effect of Hepatocyte Growth Factor (HGF) on the Microscopic Regeneration of Liver Allograft in Recipients Who Underwent Transplantation from Living Donors

    B. H. Ozdemir1, G. Ozgun1, A. Yucel Polat1, M. Haberal2

    1Pathology, Baskent University, Ankara, Turkey, 2Department of General Surgery, Division of Transplantation, Baskent University, Ankara, Turkey

    *Purpose: Although partial liver allografts from living donors have near-complete regeneration of their liver volumes within weeks after transplantation, the microscopic range of regeneration is…
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