2020 American Transplant Congress
Older Organs Transfer Senescence to Transplant Recipients
1Brigham and Women's Hospital, Boston, MA, 2Mayo Clinic, Rochester, MN
*Purpose: Older organs represent an underutilized potential. Organ age, at the same time, augments alloimmune responses resulting into increased acute rejection rates. Senescent cells accumulate…2020 American Transplant Congress
Evaluation of the Discrimination of 13 Mortality Risk Scores after Heart Transplantation in a Contemporary UNOS Cohort
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Multiple pre-transplant scores aimed at stratifying the risk of death or allograft loss after heart transplantation have been developed over time but their use…2020 American Transplant Congress
Cervical Total Arterial Anastomosis Mouse-to-Rat Heterotopic Heart Xenotransplantation
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Xenotransplantation is an effective way to solve the problem of donor shortage. However, clinical use of xenotransplantation is currently limited due to immunological challenges.…2020 American Transplant Congress
Bariatric Surgery for Congestive Heart Failure Patients Improves Access to Transplantation and Long-Term Survival
*Purpose: Obese patients with congestive heart failure (CHF) are often denied access to heart transplantation until they obtain significant weight loss to achieve a certain…2020 American Transplant Congress
p40 Homodimers Indirectly Induce Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts and CTLA-4ig Resistant Graft Rejection via IL-15 Signaling
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: We have reported that longer duration of cold ischemic storage (CIS) prior to transplant resulted in increased proliferation of endogenous donor-reactive CD8 T cells…2020 American Transplant Congress
Comparison of Outcomes between Patients Bridged to Heart Transplantation with ECMO versus Those Not Bridged with ECMO During the Years 1985 to 2019
*Purpose: Some patients with cardiogenic shock require extracorporeal membrane oxygenation (ECMO) for successful bridging to heart transplantation (HT). Herein, we report on the outcomes and…2020 American Transplant Congress
Comparing Two Methods of Minimally-Ischemic Cardiac Preservation in Life-Supporting Cardiac Xenotransplantation Model
*Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…2020 American Transplant Congress
The Art Rather Than the Science of Non-HLA Antibody Mediated Rejection in Heart Transplantation: A Single Center Experience
Cardiology, Baylor University Medical Center, Dallas, TX
*Purpose: The role of non-HLA antibodies (Ab) in HLA-DSA negative antibody mediated rejection (AMR) following heart transplant (HTx) remains largely unknown.*Methods: Retrospective analysis of all…2020 American Transplant Congress
Medication Adherence in Thoracic Transplant Candidates
*Purpose: Medication non-adherence is associated with poor outcomes in transplant recipients. It can be challenging to identify candidates at risk for medication non-adherence. The simplified…2020 American Transplant Congress
dd-cfDNA as a Risk Factor for Initiating De-Novo Donor Specific Antibodies in Heart Transplantation
*Purpose: We hypothesize that subclinical inflammation, resulting in molecular injury of the cardiac allograft, may contribute to sensitization of the recipients’ immune system. Antigenic presentation…
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