Articles tagged "Heart/lung transplantation"

2020 American Transplant Congress
Bariatric Surgery for Congestive Heart Failure Patients Improves Access to Transplantation and Long-Term Survival
R. A. Choudhury¹, G. Hoeltzel², H. B. Moore¹, H. Yaffe¹, D. Yoeli¹, K. R. Dumon³, K. D. Conzen¹, T. L. Nydam¹
¹Department of Surgery- Division of Transplantation Surgery, University of Colorado Hospital, Aurora, CO, ²Thomas Jefferson University Hospital, Philadelphia, PA, ³Department of Surgery, University of Colorado Hospital, Philadelphia, PA
*Purpose: Obese patients with congestive heart failure (CHF) are often denied access to heart transplantation until they obtain significant weight loss to achieve a certain…
2020 American Transplant Congress
p40 Homodimers Indirectly Induce Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts and CTLA-4ig Resistant Graft Rejection via IL-15 Signaling
H. Tsuda, A. Valujskikh, R. Fairchild
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: We have reported that longer duration of cold ischemic storage (CIS) prior to transplant resulted in increased proliferation of endogenous donor-reactive CD8 T cells…
2020 American Transplant Congress
Comparison of Outcomes between Patients Bridged to Heart Transplantation with ECMO versus Those Not Bridged with ECMO During the Years 1985 to 2019
D. J. Miklin¹, A. D. Salimbangon², G. S. Liu¹, P. Banankhah¹, P. A. Genyk¹, P. Kingsford¹, R. R. Chand³, J. P. Li¹, D. Vucicevic⁴, A. S. Vaidya¹, K. Pandya¹, J. Rahman¹, M. Fong¹, L. Grazette¹, A. Kiankhooy¹, J. Nattiv¹, S. Hashmi¹, S. Nuno¹, J. Pizula¹, A. E. Lee¹, K. Yang¹, S. Shaw¹, E. DePasquale¹, W. M. Aaron⁵
¹LAC-USC, Los Angeles, CA, ²UCLA Medical Center, Los Angeles, CA, ³Harbor-UCLA Medical Center, Los Angeles, CA, ⁴Newark Beth-Israel Medical Center, Newark, NJ, ⁵University of Arizona Sarver Heart Center, Tucson, AZ
*Purpose: Some patients with cardiogenic shock require extracorporeal membrane oxygenation (ECMO) for successful bridging to heart transplantation (HT). Herein, we report on the outcomes and…
2020 American Transplant Congress
Comparing Two Methods of Minimally-Ischemic Cardiac Preservation in Life-Supporting Cardiac Xenotransplantation Model
C. E. Goerlich¹, A. Singh¹, D. Kaczorowski¹, M. Abdullah¹, B. Lewis¹, I. Tatarov¹, A. Hershfeld¹, T. Zhang¹, E. Strauss¹, P. Odonkor¹, B. Williams¹, D. Ayares², B. Griffith¹, M. Mohiuddin¹
¹Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Surgery, Revivicor, Blacksburg, VA
*Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…
2020 American Transplant Congress
The Art Rather Than the Science of Non-HLA Antibody Mediated Rejection in Heart Transplantation: A Single Center Experience
A. Alam, S. Mckean, R. Patel, V. Darst, H. Zafar, C. Guerrero, M. Askar, T. Sam, S. Hall
Cardiology, Baylor University Medical Center, Dallas, TX
*Purpose: The role of non-HLA antibodies (Ab) in HLA-DSA negative antibody mediated rejection (AMR) following heart transplant (HTx) remains largely unknown.*Methods: Retrospective analysis of all…
2020 American Transplant Congress
Medication Adherence in Thoracic Transplant Candidates
K. Pennington¹, R. Benzo¹, S. Jowsey¹, M. Budev², S. Chandreashekaran³, D. Erasmus⁴, E. Lease⁵, D. Levine⁶, K. Thompson¹, D. Yip⁴, B. Hardaway⁷, S. Dunlay¹, C. Kennedy¹
¹Mayo Clinic, Rochester, MN, ²Cleveland Clinic Foundation, Cleveland, OH, ³University of Florida, Gainesville, FL, ⁴Mayo Clinic, Jacksonville, FL, ⁵University of Washington, Seattle, WA, ⁶University of Texas Health Science Center, San Antonio, TX, ⁷Mayo Clinic, Scottsdale, AZ
*Purpose: Medication non-adherence is associated with poor outcomes in transplant recipients. It can be challenging to identify candidates at risk for medication non-adherence. The simplified…
2020 American Transplant Congress
dd-cfDNA as a Risk Factor for Initiating De-Novo Donor Specific Antibodies in Heart Transplantation
E. DePasquale¹, J. Kobashigawa², S. Pinney³, K. Khush⁴
¹Keck Hospital of USC, Los Angeles, CA, ²Cedars-Sinai, Beverly Hills, CA, ³Mount Sinai Health System, New York, NY, ⁴Stanford University, Stanford, CA
*Purpose: We hypothesize that subclinical inflammation, resulting in molecular injury of the cardiac allograft, may contribute to sensitization of the recipients’ immune system. Antigenic presentation…
2020 American Transplant Congress
Myeloid Derived Suppressor Cells Expanded by Granulocyte-Colony Stimulating Factor Prolong Allogeneic Cardiac Graft Survival When Compared with MDSCs Expanded by Different Means
Y. S. Lee, T. Zhang, J. S. Bromberg, J. R. Scalea
Department of Surgery, University of Maryland, Baltimore, MD
*Purpose: Myeloid-derived suppressor cells (MDSCs) inhibit T cell responses and may provide a pathway towards tolerance. Granulocyte-colony stimulating factor (GCSF) is used in clinical practice…
2020 American Transplant Congress
Outcomes of Heart Transplantation in Adults with Congenital Heart Disease Since UNOS Allocation System Change: UNOS Registry Analysis
P. Genyk, K. Yang, J. Nattiv, G. Liu, P. Banankah, P. Kingsford, J. Li, S. Nuno, K. Pandya, A. Vaidya, E. DePasquale
Department of Cardiology, Keck Medical Center of University of Southern California, Los Angeles, CA
*Purpose: We sought to examine the waiting list and post-HT outcomes in patients with congenital heart disease (CHD) within UNOS registry since the implementation of…
2020 American Transplant Congress
Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication During Cardiac Allograft Rejection in the Mouse Heart Transplantation
Y. Tang, X. Shi, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Allograft rejection is still the leading causes of the graft loss, especially long-term outcome. Single-cell genomics techniques are revolutionizing our ability to comprehensively characterize…

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