Articles tagged "Heart/lung transplantation"

2020 American Transplant Congress
Effects of Donor Heavy Alcohol Use on Post-Heart Transplant Outcomes: Time to Abstain?
J. Patel, M. Kittleson, D. Chang, E. Kransdorf, D. Geft, A. Shen, K. Nishihara, G. Jamero, L. Czer, F. Esmailian, J. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Donors with a history of heavy alcohol use have been suspected to possibly harbor a subclinical alcoholic cardiomyopathy with limited cardiac reserve. This problem…
2020 American Transplant Congress
Agonistic Anti-CD272 Antibody (6B2) Suppressed Donor Specific Antibody Through Inducible Regulatory T Cells
Y. Yamamoto¹, M. Uchiyama², K. Uchida³, H. Yagita⁴, M. Niimi¹
¹Surgery, Teikyo University, Tokyo, Japan, ²Cardiovascular Surgery, Teikyo University, Tokyo, Japan, ³Hepato- Biliary- Pancreatic Surgery, Juntendo University, Tokyo, Japan, ⁴Immunology, Juntendo University, Tokyo, Japan
*Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) is a coinhibitory molecule and may play an important role in alloimmune responses. We…
2020 American Transplant Congress
Heart Transplant Outcomes in Patients Who Receive Hepatitis B Virus-Positive Donor Hearts: A UNOS Registry Analysis
P. Genyk¹, K. Yang², R. Chand³, E. Depasquale¹
¹Keck Medicine of USC, Los Angeles, CA, ²Keck Medicine of USC, South Pasadena, CA, ³Harbor-UCLA Medical Center, Los Angeles, CA
*Purpose: Hepatitis B infection in post-transplant patients posed a challenge in the setting of immunosuppression. However, the advent of anti-viral therapy for HBV has made…
2020 American Transplant Congress
Life Supporting Orthotopic Cardiac Xenotransplantation from Genetically Engineered Donor Pigs
A. K. Singh¹, C. E. Goerlich¹, T. Zhang¹, I. Tatarov¹, P. Odonkor¹, E. Strauss¹, B. Williams¹, B. Lewis¹, A. Hershfeld¹, F. Sentz¹, D. Ayares², D. Kaczorowski¹, B. Griffith¹, M. M. Mohiuddin¹
¹Department of Surgery, University of Maryland Baltimore, Baltimore, MD, ²Revivicor Inc, Blacksburg, VA
*Purpose: Cardiac xenotransplantation (CXTx) might be an alternative treatment for end-stage cardiac failure patients. The prolonged survival of a heterotopic genetically-engineered (GE) pig heart is…
2020 American Transplant Congress
Assessment of Coronary Allograft Vasculopathy by Intravascular Ultrasound 6 Weeks and One Year after Heart Transplantation: A Single Center Study
A. Alam, E. Dib, H. Zafar, J. Felius, S. Hall, S. Joseph
Cardiology, Baylor University Medical Center, Dallas, TX
*Purpose: Coronary allograft vasculopathy (CAV) continues to be a common cause of morbidity and mortality in heart transplant recipients. Little is known about the timing…
2020 American Transplant Congress
Detrimental Effects of Donor Brain Death on Tolerance Induction May be Eliminated by Delaying Mixed Chimerism in Non-Human Primates
J. M. O¹, W. Sommer², K. Ahrens¹, P. Patel¹, D. Becerra¹, J. Morrissette¹, T. Costa¹, K. Pruner¹, J. Paster¹, A. Bean¹, A. Dehnadi¹, I. Hanekamp¹, I. Rosales¹, R. Smith¹, R. Colvin¹, G. Benichou¹, J. Allan³, T. Kawai¹, J. Madsen⁴
¹Center for Transplantation Sciences, MGH, Boston, MA, ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, ³Division of Thoracic Surgery, MGH, Boston, MA, ⁴Division of Cardiac Surgery, MGH, Boston, MA
*Purpose: Induction of tolerance to heart allografts in non-human primates is possible with kidney cotransplantation and mixed chimerism-based induction therapy. However, donor brain death abrogates…
2020 American Transplant Congress
Challenging Dogma That Anti-Thymocyte Globulin Induction with Delayed Calcineurin Inhibitor Benefits Patients with Renal Insufficiency Undergoing Heart Transplant
M. Kittleson, J. Patel, D. Chang, E. Kransdorf, D. Geft, K. Nishihara, A. Shen, A. Velleca, L. Czer, F. Esmailian, J. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Anti-thymocyte globulin (ATG) induction is used in approximately 50% of heart transplant (HTx) patients in the United States to induce tolerance. Other programs only…
2020 American Transplant Congress
Consistent Prevention of Perioperative Cardiac Xenograft Dysfunction with Non-Ischemic Cardiac Preservation in Life-Supporting Cardiac Xenotransplantation Model
C. E. Goerlich¹, A. Singh¹, D. Kaczorowski¹, M. Abdullah¹, B. Lewis¹, I. Tatarov¹, A. Hershfeld¹, T. Zhang¹, P. Odonkor¹, A. Tabatabai¹, A. Bhutta¹, E. Strauss¹, B. Williams¹, D. Ayares², M. Mohiuddin¹
¹Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Revivicor, Blacksburg, VA
*Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…
2020 American Transplant Congress
Heart Transplant Outcomes in Adults with Peripartum Cardiomyopathy
P. Genyk, K. Yang, G. Liu, J. Nattiv, P. Banankhah, P. Kingsford, J. Li, S. Nuno, K. Pandya, A. Vaidya, E. DePasquale
Department of Cardiology, Keck Medical Center of University of Southern California, Los Angeles, CA
*Purpose: We aimed to evaluate long-term heart transplant (HT) outcomes in adults with peripartum cardiomyopathy (PPCM) and compare them to all other heart transplant recipients.*Methods:…
2020 American Transplant Congress
Older Organs Transfer Senescence to Transplant Recipients
J. Iske¹, R. Maenosono¹, M. Seyda¹, T. Heinbockel¹, M. Koichiro¹, Y. Nian¹, T. Tchkonia², J. L. Kirkland², R. Abdi¹, A. Elkhal¹, S. G. Tullius¹
¹Brigham and Women's Hospital, Boston, MA, ²Mayo Clinic, Rochester, MN
*Purpose: Older organs represent an underutilized potential. Organ age, at the same time, augments alloimmune responses resulting into increased acute rejection rates. Senescent cells accumulate…

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