Articles tagged "Heart/lung transplantation"

2020 American Transplant Congress
Do the Characteristics of Donor Specific Antibody Truly Predict Severity of Cardiac Allograft Vasculopathy Late after Transplantation?
K. Nishihara, J. Patel, M. Kittleson, D. Chang, E. Kransdorf, D. Geft, A. Shen, L. Czer, F. Esmailian, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: The development of donor specific antibody (DSA) has been correlated to the development of cardiac allograft vasculopathy (CAV) after heart transplantation. However, it has…
2020 American Transplant Congress
Exosomes Released from Natural Killer Cells Activation of Immune Responses: Role in Chronic Lung Allograft Dysfunction
R. Ravichandran, Y. Itabashi, W. Liu, M. Rahman, S. Bansal, R. Bremner, M. Smith, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Recent studies demonstrated natural killer (NK) cells can induce cytotoxicity both by direct cytotoxic mechanisms and antibody (Ab) dependent cytotoxicity; however its role in…
2020 American Transplant Congress
The Reperfusion Response in Plasma of Combined Heart/ Lung Transplanted Patients is Guided by Heart-Associated Cytokine Patterns on Contrast to the Ischemic Injury in Perfusion Solutions Following a Lung-Associated Pattern
C. Falk¹, J. Kühne², L. Radomsky², F. Wandrer², B. Wiegmann³, N. Ledwoch², J. Keil², K. Beushausen², F. Ius³, W. Sommer³, S. Rojas-Hernandez³, I. Tudorache³, A. Haverich³, G. Warnecke³
¹MHH, Institute of Transplant Immunology, Hannover, Germany, ²Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, ³Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany
*Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation but rarely compared directly in a clinical setting. Therefore, we compared a cohort…
2020 American Transplant Congress
Gal9/Tim-3 Pathway was Required for Endometrial Stem Cells to Induce Peripheral Tolerance of Cardiac Allograft
Y. Zhao¹, Y. Hu¹, D. Yu¹, X. Li¹, W. Jin¹, Y. Qin¹, D. Kong¹, H. Wang¹, A. Alessandrini², H. Wang¹
¹Tianjin Medical University General Hospital, Tianjin, China, ²Massachusetts General Hospital, Boston, MA
*Purpose: The existing immunosuppressants seem to have little effect on Cardiac Allograft Vasculopathy but with obvious side effects. ERCs (Endometrial stem Cells), which are mesenchymal-like…
2020 American Transplant Congress
High-Risk Antibodies Pre-Transplant Impacts Outcome after Heart Transplantation
J. A. Kobashigawa, M. Kittleson, J. Patel, D. Chang, E. Kransdorf, D. Geft, K. Nishihara, A. Shen, L. Czer, F. Esmailian
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Pre-transplant circulating antibodies (Abs) are known to impact outcome after heart transplantation (HTx). Abs can now be detected by single-bead assay but also characterized…
2020 American Transplant Congress
Safety and Efficacy of Prophylactic Valganciclovir Dosing after Solid Organ Transplant
K. Gandhi, D. Masic, M. Santarossa, F. Albarillo, N. Clark, G. Reid
Loyola University Medical Center, Maywood, IL
*Purpose: At centers where antiviral prophylaxis is used after solid organ transplant, valganciclovir is administered for the prevention of cytomegalovirus (CMV). At Loyola University Medical…
2020 American Transplant Congress
The Frequency of De Novo DSA in the Years Following Heart Transplantation
A. Shen, J. Patel, M. Kittleson, D. Chang, E. Kransdorf, D. Geft, K. Nishihara, L. Czer, F. Esmailian, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: The timing of the development of donor specific antibody (DSA) after heart transplantation is not clear. De novo DSA has been reported to be…
2020 American Transplant Congress
B Cell Derived IL-1β and IL-6 Drive Homeostatic T Cell Recovery Following Lymphoablation
S. Hasgur, R. Fan, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: T cell reconstitution after lymphoablation in allograft recipients may lead to acute rejection and poor graft outcome. Using a mouse model of heart transplantation…
2020 American Transplant Congress
Molecular Profiles of Injury in Heart Transplant Allograft: Relationship to Rejection, Ejection Fraction, and Survival
P. Halloran¹, J. Reeve², &. the INTERHEART Study Group³
¹University of Alberta, Edmonton, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: In previous studies we used microarray analysis of gene expression to identify rejection in heart transplant endomyocardial biopsies, and found that this also revealed…
2020 American Transplant Congress
BK-Viral Nephropathy after Transplantation of a Non-Renal Organ
A. Schwarz¹, C. Bara², J. Braesen³, J. Gottlieb⁴
¹Nephrology Department, Hannover Medical School, Hannover, Germany, ²Cardiothoracic Surgery Department, Hannover Medical School, Hannover, Germany, ³Pathology Department, Hannover Medical School, Hannover, Germany, ⁴Pulmonary Department, Hannover Medical School, Hannover, Germany
*Purpose: Patients with non-renal organ transplantation may suffer BK-viral nephropathy (BKVN) of their orthotopic kidneys by reactivation of their own viral population living in latency…

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