ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Heart/lung transplantation"

  • 2021 American Transplant Congress

    Inhibition of Fatty Acid Beta-Oxidation Prolongs Heart Allograft Survival

    B. W. Wong, Y. Zhu, H. Dun, L. Ye

    Surgery, Washington University School of Medicine, Saint Louis, MO

    *Purpose: To test the therapeutic efficacy of pharmacological inhibition of fatty acid beta-oxidation (FAO) on acute heart allograft survival.*Methods: We used a heterotopic Balb/c donor…
  • 2021 American Transplant Congress

    A Novel Mouse Model of Cardiac Allograft Vasculopathy

    H. Tsuda1, E. Reed2, W. Baldwin1, R. Fairchild1

    1Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, 2Pathology and Laboratory Medicine, University of California, Los Angeles, CA

    *Purpose: Cardiac allograft vasculopathy (CAV) is a major long-term complication of heart transplantation and the presence of donor specific antibodies (DSA) is associated with an…
  • 2021 American Transplant Congress

    Novel Morphologic Biomarkers of Cardiac Allograft Remodeling are Associated with Multiple Peri- and Post-transplant Inflammatory Processes

    C. Yuan1, S. Arabyarmohammadi1, H. Li1, E. Peyster2, P. Lal3, M. Feldman3, K. Margulies2, A. Madabhushi1

    1Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 2Cardiovascular Research Institute, University of Pennsylvania, Philadelphia, PA, 3University of Pennsylvania, Philadelphia, PA

    *Purpose: It has long been recognized that transplanted hearts develop a stiffened, restrictive physiology at an accelerated rate compared to native hearts. While this is…
  • 2020 American Transplant Congress

    Heart Transplant Outcomes in Patients Who Receive Hepatitis B Virus-Positive Donor Hearts: A UNOS Registry Analysis

    P. Genyk1, K. Yang2, R. Chand3, E. Depasquale1

    1Keck Medicine of USC, Los Angeles, CA, 2Keck Medicine of USC, South Pasadena, CA, 3Harbor-UCLA Medical Center, Los Angeles, CA

    *Purpose: Hepatitis B infection in post-transplant patients posed a challenge in the setting of immunosuppression. However, the advent of anti-viral therapy for HBV has made…
  • 2020 American Transplant Congress

    Life Supporting Orthotopic Cardiac Xenotransplantation from Genetically Engineered Donor Pigs

    A. K. Singh1, C. E. Goerlich1, T. Zhang1, I. Tatarov1, P. Odonkor1, E. Strauss1, B. Williams1, B. Lewis1, A. Hershfeld1, F. Sentz1, D. Ayares2, D. Kaczorowski1, B. Griffith1, M. M. Mohiuddin1

    1Department of Surgery, University of Maryland Baltimore, Baltimore, MD, 2Revivicor Inc, Blacksburg, VA

    *Purpose: Cardiac xenotransplantation (CXTx) might be an alternative treatment for end-stage cardiac failure patients. The prolonged survival of a heterotopic genetically-engineered (GE) pig heart is…
  • 2020 American Transplant Congress

    Assessment of Coronary Allograft Vasculopathy by Intravascular Ultrasound 6 Weeks and One Year after Heart Transplantation: A Single Center Study

    A. Alam, E. Dib, H. Zafar, J. Felius, S. Hall, S. Joseph

    Cardiology, Baylor University Medical Center, Dallas, TX

    *Purpose: Coronary allograft vasculopathy (CAV) continues to be a common cause of morbidity and mortality in heart transplant recipients. Little is known about the timing…
  • 2020 American Transplant Congress

    Detrimental Effects of Donor Brain Death on Tolerance Induction May be Eliminated by Delaying Mixed Chimerism in Non-Human Primates

    J. M. O1, W. Sommer2, K. Ahrens1, P. Patel1, D. Becerra1, J. Morrissette1, T. Costa1, K. Pruner1, J. Paster1, A. Bean1, A. Dehnadi1, I. Hanekamp1, I. Rosales1, R. Smith1, R. Colvin1, G. Benichou1, J. Allan3, T. Kawai1, J. Madsen4

    1Center for Transplantation Sciences, MGH, Boston, MA, 2Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, 3Division of Thoracic Surgery, MGH, Boston, MA, 4Division of Cardiac Surgery, MGH, Boston, MA

    *Purpose: Induction of tolerance to heart allografts in non-human primates is possible with kidney cotransplantation and mixed chimerism-based induction therapy. However, donor brain death abrogates…
  • 2020 American Transplant Congress

    Challenging Dogma That Anti-Thymocyte Globulin Induction with Delayed Calcineurin Inhibitor Benefits Patients with Renal Insufficiency Undergoing Heart Transplant

    M. Kittleson, J. Patel, D. Chang, E. Kransdorf, D. Geft, K. Nishihara, A. Shen, A. Velleca, L. Czer, F. Esmailian, J. Kobashigawa

    Cedars-Sinai Smidt Heart Institute, Los Angeles, CA

    *Purpose: Anti-thymocyte globulin (ATG) induction is used in approximately 50% of heart transplant (HTx) patients in the United States to induce tolerance. Other programs only…
  • 2020 American Transplant Congress

    Consistent Prevention of Perioperative Cardiac Xenograft Dysfunction with Non-Ischemic Cardiac Preservation in Life-Supporting Cardiac Xenotransplantation Model

    C. E. Goerlich1, A. Singh1, D. Kaczorowski1, M. Abdullah1, B. Lewis1, I. Tatarov1, A. Hershfeld1, T. Zhang1, P. Odonkor1, A. Tabatabai1, A. Bhutta1, E. Strauss1, B. Williams1, D. Ayares2, M. Mohiuddin1

    1Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Revivicor, Blacksburg, VA

    *Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…
  • 2020 American Transplant Congress

    Heart Transplant Outcomes in Adults with Peripartum Cardiomyopathy

    P. Genyk, K. Yang, G. Liu, J. Nattiv, P. Banankhah, P. Kingsford, J. Li, S. Nuno, K. Pandya, A. Vaidya, E. DePasquale

    Department of Cardiology, Keck Medical Center of University of Southern California, Los Angeles, CA

    *Purpose: We aimed to evaluate long-term heart transplant (HT) outcomes in adults with peripartum cardiomyopathy (PPCM) and compare them to all other heart transplant recipients.*Methods:…
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