Articles tagged "Heart/lung transplantation"

2021 American Transplant Congress
P40 Homodimers Induce Il-15 to Promote Endogenous Donor-reactive Memory Cd8 T Cell Activation within High-risk Cardiac Allografts
H. Tsuda, A. Valujskikh, R. Fairchild
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Longer cold ischemic storage (CIS) time prior to transplant results in increased proliferation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac…
2021 American Transplant Congress
Life-supporting Multi-gene Cardiac Xenografts From Swine Demonstrate Survival >8 Months and Preclinical Efficacy for Human Clinical Trials
C. Goerlich¹, B. Griffith¹, A. Singh¹, T. Zhang¹, I. Tatarov¹, B. Lewis¹, F. Sentz¹, A. Hershfeld¹, P. Odonkor¹, B. Williams¹, E. Strauss¹, A. Tabatabai², A. Bhutta³, D. Ayares⁴, D. Kaczorowski¹, M. Mohiuddin¹
¹Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, ³Pediatrics, Pediatric Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, ⁴Revivicor, Inc., Blacksburg, VA
*Purpose: Cardiac xenotransplantation has been proposed to bridge the gap in organ shortage for those in end-stage heart failure without the opportunity to receive a…
2021 American Transplant Congress
Outcomes of Hepatitis C Nucleic Acid Testing Positive Donors in Aviremic Recipients With Delayed Direct-Acting Antiviral Initiation
M. Hudson, A. Webb, A. Logan, A. Silverman, A. Brueckner
Pharmacy, Tampa General Hospital, Tampa, FL
*Purpose: The purpose of this study was to assess the clinical impact of utilizing hepatitis C virus (HCV) nucleic acid testing (NAT)+ donors in HCV…
2020 American Transplant Congress
Novel Approaches in Targeting Chromatin Modifiers in the Induction of Transplant Tolerance
G. Wang, X. Xiao, Y. Dou, G. Kong, X. Li
Houston Methodist Research Institute, Houston, TX
*Purpose: Bromodomain and extra-terminal domain (BET) proteins are a family of proteins that function as epigenetic readers that regulate transcriptional activities of target genes. BET…
2020 American Transplant Congress
The Effect of UNOS Donor Policy Change on Ischemic Time and the Effects on Mortality in Heart Transplantation
A. Lee¹, K. Yang¹, G. Liu¹, C. Lum², A. D. Salimbangon³, R. R. Chand⁴, P. Banankhah¹, P. Genyk¹, P. Kingsford¹, J. Li¹, J. Li¹, D. Vucicevic⁵, K. Pandya¹, J. Rahman¹, M. Fong¹, L. Grazette¹, A. Kiankhooy¹, J. [email protected]¹, S. Hashmi¹, A. Gong¹, J. Pizula¹, D. Miklin¹, S. Shah¹, A. Vaidya¹, A. Wolfson⁶, E. Depasquale¹
¹Keck Medicine of USC, Los Angeles, CA, ²The Queens Medical Center, Honolulu, HI, ³UCLA Medical Center, Los Angeles, CA, ⁴Harbor-UCLA Medical Center, Los Angeles, CA, ⁵Newark Beth-Israel Medical Center, Newark, NJ, ⁶University of Arizona Sarver Heart Center, Tuscon, AZ
*Purpose: In light of the recent change in the UNOS allocation policy, we sought to evaluate the impact of ischemic time on mortality.*Methods: Using the…
2020 American Transplant Congress
Patient Attitudes Regarding Contraception and Pregnancy after Transplantation
P. Puerzer¹, T. McIntosh², C. Sammons³, N. Casciello³, T. Fallah³, M. Norris³, M. Sumit⁴, J. DuBois⁵, A. Iltis⁶, D. Sawinski¹
¹Univ of Pennsylvania, Philadelphia, PA, ²Washington Univ in St Louis, St Louis, MO, ³Pharmacy, Hospital of the Univ of Pennsylvania, Philadelphia, PA, ⁴Columbia Univ, New York, NY, ⁵Washington Univ in St Louis, St. Louis, MO, ⁶Wake Forest Univ, Winston-Salem, NC
*Purpose: Professional society recommendations regarding contraception and pregnancy after transplantation exist but little is known about patient attitudes.*Methods: We conducted a survey of female transplant…
2020 American Transplant Congress
Do the Characteristics of Donor Specific Antibody Truly Predict Severity of Cardiac Allograft Vasculopathy Late after Transplantation?
K. Nishihara, J. Patel, M. Kittleson, D. Chang, E. Kransdorf, D. Geft, A. Shen, L. Czer, F. Esmailian, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: The development of donor specific antibody (DSA) has been correlated to the development of cardiac allograft vasculopathy (CAV) after heart transplantation. However, it has…
2020 American Transplant Congress
Exosomes Released from Natural Killer Cells Activation of Immune Responses: Role in Chronic Lung Allograft Dysfunction
R. Ravichandran, Y. Itabashi, W. Liu, M. Rahman, S. Bansal, R. Bremner, M. Smith, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Recent studies demonstrated natural killer (NK) cells can induce cytotoxicity both by direct cytotoxic mechanisms and antibody (Ab) dependent cytotoxicity; however its role in…
2020 American Transplant Congress
The Reperfusion Response in Plasma of Combined Heart/ Lung Transplanted Patients is Guided by Heart-Associated Cytokine Patterns on Contrast to the Ischemic Injury in Perfusion Solutions Following a Lung-Associated Pattern
C. Falk¹, J. Kühne², L. Radomsky², F. Wandrer², B. Wiegmann³, N. Ledwoch², J. Keil², K. Beushausen², F. Ius³, W. Sommer³, S. Rojas-Hernandez³, I. Tudorache³, A. Haverich³, G. Warnecke³
¹MHH, Institute of Transplant Immunology, Hannover, Germany, ²Institute of Transplant Immunology, Hannover Medical School MHH, Hannover, Germany, ³Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School MHH, Hannover, Germany
*Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation but rarely compared directly in a clinical setting. Therefore, we compared a cohort…
2020 American Transplant Congress
Gal9/Tim-3 Pathway was Required for Endometrial Stem Cells to Induce Peripheral Tolerance of Cardiac Allograft
Y. Zhao¹, Y. Hu¹, D. Yu¹, X. Li¹, W. Jin¹, Y. Qin¹, D. Kong¹, H. Wang¹, A. Alessandrini², H. Wang¹
¹Tianjin Medical University General Hospital, Tianjin, China, ²Massachusetts General Hospital, Boston, MA
*Purpose: The existing immunosuppressants seem to have little effect on Cardiac Allograft Vasculopathy but with obvious side effects. ERCs (Endometrial stem Cells), which are mesenchymal-like…

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