ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Heart/lung transplantation"

  • 2022 American Transplant Congress

    Donor Derived Cell-Free DNA Median and Distribution in Pediatric Heart Transplant Patients

    J. N. Gray1, J. Miles1, K. Oreschak1, L. Jenkins1, B. Feingold2

    1CareDx, South San Francisco, CA, 2Children's Hosp of Pittsburgh, Pittsburgh, PA

    *Purpose: The utilization of endomyocardial biopsy (EMB) in the post-transplant surveillance of pediatric heart transplant (pHT) recipients can be challenging for a myriad of reasons;…
  • 2022 American Transplant Congress

    Superoxide in Cardiac Allografts from Donors After Circulatory Death

    M. Urban1, T. Bruett2, K. F. Duncan1, N. W. Markin3, M. M. Chacon3, M. C. Zimmerman4

    1Department of Surgery. Division of Cardiothoracic Surgery, University of Nebraska Medical Center, Omaha, NE, 2College of Medicine. Department of Cellular and Integtrative Physiology., University of Nebraska Medical Center, Omaha, NE, 3Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, 4Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE

    *Purpose: Quality of cardiac allografts from donors after circulatory death (DCD) is adversely impacted by warm ischemia and subsequent reperfusion during organ resuscitation. Post-transplant myocardial…
  • 2022 American Transplant Congress

    Early Retrieval of the Right Kidney for Combined Heart and Kidney Transplantation is Feasible and Reduces Costs

    H. Podder1, R. McMillan2, S. Yi2, M. Hobeika3, D. Nguyen2, E. Graviss2, R. Whitehead2, R. J. Knight4, M. Ghobrial2, A. O. Gaber2

    1The Methodist Hospital, Houston, TX, 2Houston Methodist Hospital, Houston, TX, 3Houston Methodist, Houston, TX, 4Surgery, Houston Methodist Hospital, Houston, TX

    *Purpose: Combined heart and kidney transplants (cHKT) have increased in recent years. Standard procurement practice often necessitates kidney extraction and packaging after the heart team…
  • 2021 American Transplant Congress

    The Role of Notch2 in Antibody-mediated Alloimmune Response

    R. Benedetti Gassen1, N. Murakami2, T. J Borges1, A. Al Jurdi1, A. Alessandrini1, L. V Riella1

    1Center of Transplantation Science, Massachusetts General Hospital, Boston, MA, 2Brigham and Women's Hospital, Boston, MA

    *Purpose: Antibody mediated rejection is the leading cause of chronic allograft rejection. Developing a novel therapeutic target to inhibit chronic rejection is an urgent need…
  • 2021 American Transplant Congress

    P40 Homodimers Induce Il-15 to Promote Endogenous Donor-reactive Memory Cd8 T Cell Activation within High-risk Cardiac Allografts

    H. Tsuda, A. Valujskikh, R. Fairchild

    Inflammation and Immunity, Cleveland Clinic, Cleveland, OH

    *Purpose: Longer cold ischemic storage (CIS) time prior to transplant results in increased proliferation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac…
  • 2021 American Transplant Congress

    Life-supporting Multi-gene Cardiac Xenografts From Swine Demonstrate Survival >8 Months and Preclinical Efficacy for Human Clinical Trials

    C. Goerlich1, B. Griffith1, A. Singh1, T. Zhang1, I. Tatarov1, B. Lewis1, F. Sentz1, A. Hershfeld1, P. Odonkor1, B. Williams1, E. Strauss1, A. Tabatabai2, A. Bhutta3, D. Ayares4, D. Kaczorowski1, M. Mohiuddin1

    1Surgery, University of Maryland School of Medicine, Baltimore, MD, 2Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, 3Pediatrics, Pediatric Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, 4Revivicor, Inc., Blacksburg, VA

    *Purpose: Cardiac xenotransplantation has been proposed to bridge the gap in organ shortage for those in end-stage heart failure without the opportunity to receive a…
  • 2021 American Transplant Congress

    Outcomes of Hepatitis C Nucleic Acid Testing Positive Donors in Aviremic Recipients With Delayed Direct-Acting Antiviral Initiation

    M. Hudson, A. Webb, A. Logan, A. Silverman, A. Brueckner

    Pharmacy, Tampa General Hospital, Tampa, FL

    *Purpose: The purpose of this study was to assess the clinical impact of utilizing hepatitis C virus (HCV) nucleic acid testing (NAT)+ donors in HCV…
  • 2021 American Transplant Congress

    Pilot Study for the Use of Shortened Preemptive Therapy with Glecaprevir/pibrentasvir (g/p) and Ezetimibe in Hepatitis C Seronegative Solid Organ Transplant Recipients (Kidney and Heart) of Hepatitis C Viremic Donors

    B. Aqel1, H. Khamash2, A. Moss3, D. E. Steidley4, R. C. Dickson1

    1Gastroenterology and Hepatology, Mayo Clinic, Phoenix, AZ, 2Nephrology and Hypertension, Mayo Clinic, Phoenix, AZ, 3Transplant Surgery, Mayo Clinic, Phoenix, AZ, 4Cardiology, Mayo Clinic, Phoenix, AZ

    *Purpose: This prospective study aims to assess the efficacy of preemptive therapy with eight days of a combination of direct-acting antivirals (DAAs) (Mavyret) (Pibrentasvir /Glecaprevir)…
  • 2021 American Transplant Congress

    Inhibition of Fatty Acid Beta-Oxidation Prolongs Heart Allograft Survival

    B. W. Wong, Y. Zhu, H. Dun, L. Ye

    Surgery, Washington University School of Medicine, Saint Louis, MO

    *Purpose: To test the therapeutic efficacy of pharmacological inhibition of fatty acid beta-oxidation (FAO) on acute heart allograft survival.*Methods: We used a heterotopic Balb/c donor…
  • 2021 American Transplant Congress

    A Novel Mouse Model of Cardiac Allograft Vasculopathy

    H. Tsuda1, E. Reed2, W. Baldwin1, R. Fairchild1

    1Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, 2Pathology and Laboratory Medicine, University of California, Los Angeles, CA

    *Purpose: Cardiac allograft vasculopathy (CAV) is a major long-term complication of heart transplantation and the presence of donor specific antibodies (DSA) is associated with an…
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