Articles tagged "Heart/lung transplantation"

2022 American Transplant Congress
Direct Procurement of Heart and Lungs from a Controlled DCD Donor with Ongoing Abdominal Normothermic Regional Perfusion (aNRP) – A Synchronized Retrieval
M. Husain¹, A. Jothidasan¹, C. Zeschky¹, M. Osman², M. Berman², R. Gaurav³, A. Butler³, C. Watson³, B. Stutchfield⁴, I. Currie⁵, G. Oniscu⁵, J. Dunning¹, U. Stock¹
¹Department of Cardiothoracic Surgery, Transplantation and MCS, Royal Brompton & Harefield Hospitals Part of Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, ²Department of Heart and Lung Transplant, Royal Papworth Hospital, Cambridge, United Kingdom, ³Roy Calne Transplant Unit, Department of Surgery, Addenbrookes Hospital, Cambridge University NHS Trust, Cambridge, United Kingdom, ⁴Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh, Edinburgh, United Kingdom, ⁵Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
*Purpose: With the increased number of aNRP in controlled DCD donors comes a high demand for techniques to directly procure cardiothoracic organs during the aNRP.…
2022 American Transplant Congress
Using mTOR Inhibitor Nanoimmunotherapy to Induce Cardiac Allograft Tolerance in Non-Human Primates
J. M. O¹, P. M. Patel², A. J. Teunissen³, C. L. Miller⁴, T. Costa¹, M. Momodu¹, D. Muldoon¹, A. Dehnadi¹, I. M. Hanekamp¹, V. Pothula⁵, R. Sanchez-Tarjuelo⁶, G. Prevot⁶, W. J. Mulder⁶, J. Allan⁷, J. Ochando⁸, J. Madsen⁹
¹MGH, Boston, MA, ²Emory University, Atlanta, GA, ³Icahn School of Medicine at Mount Sinai, New york, NY, ⁴Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ⁵Icahn School of Medicine at Mount Sinai, New York, NM, ⁶Icahn School of Medicine at Mount Sinai, New York, NY, ⁷Massachusetts General Hospital - Harvard Medical S, Marblehead, MA, ⁸Mount Sinai School of Med, New York, NY, ⁹Massachusetts General Hospital, Boston, MA
*Purpose: Though tolerance of kidney allografts has been consistently achieved using a mixed-chimerism model, cardiac allografts remain resistant to tolerance induction. Lipoprotein-based nanobiologics loaded with…
2022 American Transplant Congress
Pre-Emptive Rituximab Use for Epstein-Barr Virus (EBV) Viremia in Cardiothoracic Solid Organ Transplant Recipients
B. Astorga, A. Loethen, L. Potter
University of Chicago Medicine, Chicago, IL
*Purpose: EBV viremia is associated with potentially life-threatening post-transplant lymphoproliferative disorders (PTLD) after solid organ transplantation. The utility of rituximab for treating EBV viremia in…
2021 American Transplant Congress
Anti-CD272 Antibody (6B2) Generated Foxp3⁺Regulatory T Cells and Suppressed Donor Specific Antibody in Murine Cardiac Transplant Model
Y. Yamamoto¹, M. Uchiyama², K. Uchida³, H. Yagita³, M. Niimi¹
¹Department of Surgery, Teikyo University, Tokyo, Japan, ²Department of Cardiovascular Surgery, Teikyo University, Tokyo, Japan, ³Juntendo University, Tokyo, Japan
*Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
2021 American Transplant Congress
Cold Perfusion for Ischemia Minimization Reduces Cardiac Injury in an Ex Vivo Xenoperfusion Model
M. R. Connolly¹, A. Calhoun¹, F. Pollok¹, L. Burdorf¹, Z. Habibabady¹, M. Ma¹, S. Miura¹, W. Eyestone², C. Phelps², D. Ayares²
¹Massachusetts General Hospital, Boston, MA, ²Revivicor, Blacksburg, VA
*Purpose: Prior studies using Steen’s cold perfusion storage technique for heart ischemia minimization (IM) prevented initial xenograft dysfunction (IXD). Our pilot data evaluates the effect…
2021 American Transplant Congress
Impact of New Onset Diabetes After Transplantation on Heart Transplant Recipients
W. Kang¹, W. Keattiyoat², M. Kim¹, C. Bhardwaj²
¹Department of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, ²Department of Cardiology, University of Illinois College of Medicine at Peoria, Peoria, IL
*Purpose: The purpose of this study is to investigate New Onset Diabetes After Transplantation (NODAT) incidence and its impact on post-transplant prognosis in adult heart…
2021 American Transplant Congress
Changes to Adult Heart Allocation Improve Candidate Stratification
K. Bradbrook¹, K. Lindblad¹, R. R. Goff¹, R. Daly², S. Hall³
¹Research, United Network for Organ Sharing, Richmond, VA, ²Mayo Clinic, Rochester, MN, ³Baylor University Medical Center, Dallas, TX
*Purpose: Historically, heart allocation has been driven by waitlist (WL) mortality rather than post-transplant survival. On 10/18/2018 the Organ Procurement and Transplantation Network (OPTN) implemented…
2021 American Transplant Congress
BKV-Associated Urothelial Carcinoma in Patients After Renal and Extrarenal Carcinoma
A. Schwarz¹, J. Schmitz², J. Gottlieb³, C. Bara⁴, H. Haller¹, J. Braesen²
¹Nephrology Department, Hannover Medical School, Hannover, Germany, ²Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Pneumology, Hannover Medical School, Hannover, Germany, ⁴Department of Thoracic Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Polyomavirus BK (BKV) reactivation or transmission is a wellknown problem in renal transplant (TX) patients with BKV nephropathy and interstitial cystitis. The role of…
2021 American Transplant Congress
Mortality, Risk Factors, and Treatment of Covid-19 Infection in Solid Organ Transplants: A Systematic Review and Meta-analysis
S. Yin, T. Song, Q. Zhong, T. Lin
Urology Institute and Organ Transplantation Center, West China Hospital, Chengdu, China
*Purpose: Outcomes for solid organ transplants (SOT) with COVID-19 have not been summarized, and prognostic factors for COVID-19 in SOT patients are not well established…
2021 American Transplant Congress
Hepatitis E Diagnosis and Management After Liver, Kidney, or Heart Transplant: A Single Center Experience
M. Carter¹, M. Fitzmaurice², S. Yeddula², A. Singh², S. Nagai², S. Jafri²
¹Wayne State University School of Medicine, Detroit, MI, ²Henry Ford Health System, Detroit, MI
*Purpose: Transplant-related Hepatitis E virus (HEV) infection is a rarely recognized entity with significant clinical importance given potential for chronic hepatitis post-transplant. We evaluated HEV…