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American Transplant Congress abstracts

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Articles tagged "Heart/lung transplantation"

  • 2016 American Transplant Congress

    Fatty Liver in Non-Hepatic Organ Transplantation.

    N. Kemmer, A. Alsina.

    Tampa General Medical Group, Tampa, FL.

    With the availability of effective antiviral regimen for HCV, Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in western countries and…
  • 2016 American Transplant Congress

    Cytomegalovirus Infection After Cardiac Transplantation.

    O. Kiamanesh, A. Khosla, C. Imai, E. Johansson, S. Virani, M. Davis, A. Cheung, J. Bashir, B. Munt, A. Ignaszewski, A. Kaan, M. Toma.

    University of British Columbia, Vancouver, Canada.

    BackgroundOrthotopic heart transplantation (OHT) continues to be the gold standard for the management of patients with end-stage heart failure. However, complications following OHT may result…
  • 2016 American Transplant Congress

    The Increase of Serum MiR-142-3p Level in Acute Cardiac Rejection as a Reflection of Exosome-Mediated Genetic Exchange Between T Cells and Endothelial Cells.

    I. Dewi,1 Z. Hollander,2 B. McManus,2 O. Gidlöf,1 J. Öhman.1

    1Cardiology, Lund University, Lund, Sweden; 2PROOF Center of Excellence, Vancouver, Canada.

    IntroductionIn the recent years, microRNAs has emerged as the popular biomarker candidate in the field of solid organ transplantation due to their expression patterns reflect…
  • 2016 American Transplant Congress

    Necroptosis Is Involved in CD4+ T-Cell Mediated Microvascular Endothelial Cell Death and Chronic Cardiac Allograft Rejection.

    C. Kwok,1,2 N. Montwill,1,2 A. Pavlosky,1,2 A. Haig,2 X.-Y. Huang,1 A. Jevnikar,1,3 Z.-X. Zhang.1,2,3

    1Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada; 2Department of Pathology and Laboratory Medicine, Western University, London, Canada; 3Department of Medicine, Western University, London, Canada.

    Heart transplantation is potentially the only viable option for patients with end-stage heart failure. Despite advances in immunosuppressive therapies, cardiac allograft chronic rejection is a…
  • 2016 American Transplant Congress

    CMV-Accelerated Cardiac Allograft Rejection Is Associated with Dysregulation of Sphingolipid Metabolomics.

    J. Burg,1 T. Andoh,2 N. Haese,2 C. Kreklywich,2 K. Watters,3 T. Metz,3 S. Orloff,1 D. Streblow.2

    1Abdominal Organ Transplantation, OHSU, Portland, OR; 2VGTI, OHSU, Portland, OR; 3Biological Sciences Division, PNNL, Richland, WA.

    PurposeCytomegalovirus (CMV) infection accelerates transplant vascular sclerosis (TVS) and chronic rejection (CR) in solid organ transplants. Sphingolipid metabolism plays an immunomodulatory role in transplant rejection,…
  • 2016 American Transplant Congress

    The Impact of Sequential Gene Modifications on Cardiac Xenograft Survival.

    K. Horvath,1 A. Singh,1 J. Chan,1 M. Thomas,2 B. Lewis,2 D. Ayares,3 P. Corcoran,1 M. Mohiuddin.1

    1CSRP, NHLBI/NIH, Bethesda, MD; 2DVR / ORS, NIH, Bethesda, MD; 3Revivicor, Inc, Blacksburg, VA.

    Introduction: One of the major advances in xenotransplantation is the ability to modify donor pig genetics. Using rapidly evolving techniques of pig cloning and gene…
  • 2016 American Transplant Congress

    Anti-BTLA Antibody (6B2) Induced Prolongation of Fully MHC-Mismatched Murine Cardiac Allograft and Generation of Foxp3+ Regulatory T Cells.

    M. Uchiyama,1,2 E. Yin,2,3 X. Jin,2,4 T. Shimokawa,1 H. Yagita,5 M. Niimi.2

    1Cardiovascular Surgery, Teikyo University, Tokyo, Japan; 2Surgery, Teikyo University, Tokyo, Japan; 3Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; 4Thoracic Surgery, The 3rd Affiliated Hospital of Harbin Medical University, Harbin, China; 5Immunology, Juntendo University Hospital, Tokyo, Japan.

    Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
  • 2016 American Transplant Congress

    Inclusion of Human Tissue Factor Pathway Inhibitor or Thrombomodulin Transgenes Attenuates Critical Consumptive Thrombocytopenia in Cardiac Xenotransplantation.

    J. Chan,1 A. Singh,1 P. Corcoran,1 M. Thomas III,2 B. Lewis,2 D. Ayares,3 K. Horvath,1 M. Mohiuddin.1

    1Cardiothoracic Surgery Research Program/National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD; 2Division of Veterinary Resources, National Institutes of Health, Bethesda, MD; 3Revivicor Inc., Blacksburg, VA.

    ObjectiveA major obstacle in the success of cardiac xenotransplantation has been the development of significant consumptive thrombocytopenia, frequently limiting recipient survival. Advances in genetic engineering…
  • 2016 American Transplant Congress

    MicroRNA let-7i Regulates Dendritic Cells Maturation Targeting Interleukin-10 via JAK1-STAT3 Signal Pathway Subsequently Induces Prolonged Cardiac Allograft Survival in Rats.

    X. Jin,1 Y. Sun,2 X. Liu,2 J. Wang,1 S. Xu,1 L. Yao,1 Z. Zhao,3 L. Jiang,4 Q. Wu,5 J. Wu.2

    1Thoracic Surgery, The Third Affiliated Hospital of Harbin Medical University, Harbin, China; 2Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, China; 3Pediatric Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China; 4Otorhinolaryngology, The First Affiliated Hospital of Harbin Medical University, Harbin, China; 5Ophthalmology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

    Background:Our previous study demonstrated that microRNA (MiR) let-7i could regulate dendritic cells (DCs) maturation and functional state via targeting SOCS1. In this study, we investigated…
  • 2016 American Transplant Congress

    Costimulation Blockade by Anti CD40 Antibody Prevents Humoral and Cellular Rejection of Heterotopic Pig Cardiac Xenograft.

    A. Singh,1 J. Chan,1 P. Corcoran,1 B. Lewis,2 M. Thomas,2 D. Ayares,3 K. Horvath,1 M. Mohiuddin.1

    1CSRP/NHLBI, NIH, Bethesda, MD; 2DVR/ORS, NIH, Bethesda, MD; 3Revivicor Inc., Blacksburg, VA.

    BackgroundXenotransplantation (XTx) involves the participation of innate immune system with natural antibody producing B cells, NK cells, macrophages and complement as well as adaptive immune…
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