2016 American Transplant Congress
Is Donor Methamphetamine Use a Contraindication in Heart Transplantation?
Cedars-Sinai Heart Institute, Los Angeles, CA.
Background: Donor methamphetamine (meth) use has been a relative contraindication for the use of the donor hearts for patients awaiting heart transplantation. The concern is…2016 American Transplant Congress
Intracellular OPN Is an Essential Protective Factor for Cardiac Endothelial Cell and the Long Term Heart Graft Survival.
[Background] Endothelial cell (EC) injury is central to cardiac allograft vasculopathy and premature graft loss. Osteopontin (OPN) is a multifunctional anti-apoptotic protein that is involved…2016 American Transplant Congress
Outcome of the Various Pathology Grades of Antibody-Mediated Rejection After Heart Transplantation.
Cedars-Sinai Heart Institute, Los Angeles, CA.
Background: The pathology scale for antibody-mediated rejection (AMR) was approved by the board of directors in 2013. The ISHLT AMR grading scale consists of pAMR…2016 American Transplant Congress
Transfer of Donor-Derived Exosomes to Recipient Ag-Presenting Cells Is Critical for Allograft Recognition.
After organ transplantation, T cells are primed against donor MHC molecules by donor dendritic cells (DCs) mobilized from the graft. Nevertheless, evidence suggests that donor…2016 American Transplant Congress
Assessment of Molecular Mechanisms of Non-Transplant Cardiac Hypertrophy in Cardiac Allograft Hypertrophy – An Exploratory Gene Array Study of Myocardial Biopsy Samples.
Cardiac Allograft Hypertrophy (CAH) develops in up to 80% of patients as early as six months post-transplant, and is associated with decreased quality of life…2016 American Transplant Congress
mTORC2 Negatively Regulates Dendritic Cell (DC) Metabolism and the Allostimulatory Function of Donor DCs in Organ Transplantation.
The mechanistic target of rapamycin (mTOR) is a kinase that functions in at least two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play…2016 American Transplant Congress
Heart and Kidney Transplants in Patients with Mechanical Circulatory Support: Who Needs a Kidney?
Cedars-Sinai Heart Institute, Los Angeles, CA.
Background: Advance Heart Disease may result in cardio-renal syndrome and thereby cause renal insufficiency. These patients (pts) can be optimized with medical therapy with reversal…2016 American Transplant Congress
Rapamycin Nanotherapy Delays Heart Transplant Rejection.
Background:In patients, allograft survival requires a cocktail of immunosuppressive drugs, while experimentally antibodies targeting the innate immune system have been shown to induce long-term tolerance,…2016 American Transplant Congress
Prednisone Wean After Dual Heart and Kidney Transplantation: Is There a Risk?
Cedars-Sinai Heart Institute, Los Angeles, CA.
Background: Corticosteroids are the cornerstone of immunosuppressive therapy post transplant (Tx)but there are deleterious effects of long-term use. A protocol of corticosteroid weaning starting 6-12…2016 American Transplant Congress
Macrophage Specific Deletion of RhoA Impedes Macrophage Functions and Abrogates Chronic Rejection of Cardiac Allograft.
Surgery, The Houston Methodist, Houston, TX.
Objective. Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Chronic rejection occurs in 40-45% of recipients at…
American Transplant Congress abstracts