2016 American Transplant Congress
mTORC2 Negatively Regulates Dendritic Cell (DC) Metabolism and the Allostimulatory Function of Donor DCs in Organ Transplantation.
The mechanistic target of rapamycin (mTOR) is a kinase that functions in at least two complexes: rapamycin (RAPA)-sensitive mTORC1 and RAPA-insensitive mTORC2. These complexes play…2016 American Transplant Congress
Heart and Kidney Transplants in Patients with Mechanical Circulatory Support: Who Needs a Kidney?
Cedars-Sinai Heart Institute, Los Angeles, CA.
Background: Advance Heart Disease may result in cardio-renal syndrome and thereby cause renal insufficiency. These patients (pts) can be optimized with medical therapy with reversal…2016 American Transplant Congress
Rapamycin Nanotherapy Delays Heart Transplant Rejection.
Background:In patients, allograft survival requires a cocktail of immunosuppressive drugs, while experimentally antibodies targeting the innate immune system have been shown to induce long-term tolerance,…2016 American Transplant Congress
Prednisone Wean After Dual Heart and Kidney Transplantation: Is There a Risk?
Cedars-Sinai Heart Institute, Los Angeles, CA.
Background: Corticosteroids are the cornerstone of immunosuppressive therapy post transplant (Tx)but there are deleterious effects of long-term use. A protocol of corticosteroid weaning starting 6-12…2016 American Transplant Congress
Macrophage Specific Deletion of RhoA Impedes Macrophage Functions and Abrogates Chronic Rejection of Cardiac Allograft.
Surgery, The Houston Methodist, Houston, TX.
Objective. Chronic rejection of transplanted organs remains the main obstacle in the long-term success of organ transplantation. Chronic rejection occurs in 40-45% of recipients at…2016 American Transplant Congress
Liver Evaluation for Heart Transplantation: Which Is Better, Noninvasive Scans or Liver Biopsy?
Cedars-Sinai Heart Institute, Los Angeles, CA.
Background: Patients awaiting heart transplantation who have known liver disease from congestive hepatopathy are at increased risk for mortality post-transplantation. The evaluation of the liver…2016 American Transplant Congress
Rituximab Induction in Cardiac Transplantation Is Associated with Accelerated Coronary Artery Vasculopathy: CTOT11.
On Behalf of the CTOT11 Consortium, Brigham & Women's Hospital, Boston, MA.
PurposeThe NIH-funded study CTOT11: Prevention of Cardiac Allograft Vasculopathy Using Rituximab (RIT) Therapy in Cardiac Transplantation, was a randomized clinical trial in non-sensitized primary heart…2016 American Transplant Congress
Comparison of Actual versus Goal Tacrolimus Levels Post Cardiothoracic Transplant.
Vanderbilt Transplant Center, Nashville, TN.
BackgroundAlthough target tacrolimus (TAC) trough levels necessary to prevent rejection are established post heart/lung transplant (tx), there is little published literature on the proportion of…2016 American Transplant Congress
Fatty Liver in Non-Hepatic Organ Transplantation.
Tampa General Medical Group, Tampa, FL.
With the availability of effective antiviral regimen for HCV, Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in western countries and…2016 American Transplant Congress
Cytomegalovirus Infection After Cardiac Transplantation.
University of British Columbia, Vancouver, Canada.
BackgroundOrthotopic heart transplantation (OHT) continues to be the gold standard for the management of patients with end-stage heart failure. However, complications following OHT may result…
American Transplant Congress abstracts