Articles tagged "Heart/lung transplantation"

2022 American Transplant Congress
Real-Time Biometric Monitoring Using Wearable Devices for Pediatric Heart Transplant Rejection and Infection Surveillance
D. Gandla¹, J. B. Edelson², E. Mukhtar¹, J. Callanan¹, H. Lad¹, H. Gao¹, J. Cornetta¹, B. Keating¹
¹Department of Surgery, Perelman School of Medicine, Philadelphia, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Monitoring for acute rejection (AR) after orthotopic heart transplantation (OHTx) is primarily achieved by evaluating histological endomyocardial biopsies (EMBx). However, this procedure is limited…
2022 American Transplant Congress
Evaluation of Conversion from Immediate Release (IR) Tacrolimus to LCP-Tacrolimus (Envarsus XR®, LCP) in Heart Transplant Recipients
E. Foster¹, A. Iaria¹, J. Negrelli², M. Fine², M. Yu², M. Liebo²
¹University of Illinois at Chicago, Chicago, IL, ²Loyola University Medical Center, Maywood, IL
*Purpose: The purpose of this study was to assess outcomes in heart transplant recipients who were converted from IR tacrolimus to LCPT. Limited data exists…
2022 American Transplant Congress
Donor Derived Cell-Free DNA Median and Distribution in Pediatric Heart Transplant Patients
J. N. Gray¹, J. Miles¹, K. Oreschak¹, L. Jenkins¹, B. Feingold²
¹CareDx, South San Francisco, CA, ²Children's Hosp of Pittsburgh, Pittsburgh, PA
*Purpose: The utilization of endomyocardial biopsy (EMB) in the post-transplant surveillance of pediatric heart transplant (pHT) recipients can be challenging for a myriad of reasons;…
2022 American Transplant Congress
Superoxide in Cardiac Allografts from Donors After Circulatory Death
M. Urban¹, T. Bruett², K. F. Duncan¹, N. W. Markin³, M. M. Chacon³, M. C. Zimmerman⁴
¹Department of Surgery. Division of Cardiothoracic Surgery, University of Nebraska Medical Center, Omaha, NE, ²College of Medicine. Department of Cellular and Integtrative Physiology., University of Nebraska Medical Center, Omaha, NE, ³Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE
*Purpose: Quality of cardiac allografts from donors after circulatory death (DCD) is adversely impacted by warm ischemia and subsequent reperfusion during organ resuscitation. Post-transplant myocardial…
2022 American Transplant Congress
Early Retrieval of the Right Kidney for Combined Heart and Kidney Transplantation is Feasible and Reduces Costs
H. Podder¹, R. McMillan², S. Yi², M. Hobeika³, D. Nguyen², E. Graviss², R. Whitehead², R. J. Knight⁴, M. Ghobrial², A. O. Gaber²
¹The Methodist Hospital, Houston, TX, ²Houston Methodist Hospital, Houston, TX, ³Houston Methodist, Houston, TX, ⁴Surgery, Houston Methodist Hospital, Houston, TX
*Purpose: Combined heart and kidney transplants (cHKT) have increased in recent years. Standard procurement practice often necessitates kidney extraction and packaging after the heart team…
2022 American Transplant Congress
p40 Homodimers Stimulate Graft Dendritic Cells to Produce IL-15 Driving Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts
H. Tsuda¹, A. Valujskikh², R. Fairchild³
¹Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, ²The Cleveland Clinic Fdn, Cleveland, OH, ³Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Acute allograft injury occurring during the first 1-2 days post-transplant is mediated by graft infiltrating endogenous donor-reactive memory CD8 T cells and requires their…
2022 American Transplant Congress
Anti-CD80/86 Antibody (RM80/GL-1) Suppressed Murine Donor Specific Antibody Through Anergy CD4⁺T Cells
Y. Yamamoto¹, K. Uchida², K. Iguchi¹, M. Niimi³, M. Uchiyama¹
¹Department of Cardiovascular Surgery, Teikyo University, Tokyo, Japan, ²Juntendo University, Tokyo, Japan, ³Department of Surgery, Teikyo University, Tokyo, Japan
*Purpose: The interactions between CD80 and CD86 on antigen-presenting cells and CD28 on T cells may play an important role in alloimmune responses. We investigated…
2022 American Transplant Congress
Humoral Response After a Third Dose of Sars-CoV-2 mRNA Vaccine in Transplant Recipients
A. E. Woolley, N. Sharma, G. Zhou, A. Kim, E. Ryan, M. Joyce, H. Goldberg, M. Givertz, M. Mehra, E. Woodcome, V. Durney, S. Marshall, K. Townsend, A. Coppolino, S. Tullius, S. Malek, H. Mallidi, L. Baden, A. Chandraker
Brigham & Women's Hospital, Boston, MA
*Purpose: Prior studies demonstrated an increased immune response post-3rd COVID-19 vaccine dose when given 1-month post-2nd dose in solid organ transplant recipients (SOT). This study…
2022 American Transplant Congress
Role of Group 2 Innate Lymphoid Cells in Murine Heart Transplant
J. Ge¹, L. Ott¹, A. Das¹, J. Markmann², A. Cuenca¹
¹Department of Surgery, Boston Children's Hospital, Boston, MA, ²Division of Transplant Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Group 2 innate lymphoid cells (ILC2s) have been shown to play key roles in manipulating adaptive immunity. They regulate CD4+ T cell biology not…
2022 American Transplant Congress
Life Supporting Orthotopic Cardiac Xenotransplantation Using Multiple Human Gene Expressing Pigs in Non Human Primates
A. K. Singh¹, C. Goerlich¹, T. Zhang¹, I. Tatarov¹, P. Odonkor¹, E. Strauss¹, B. Williams¹, B. Lewis¹, A. Hershfeld¹, F. Sentz¹, D. Ayares², D. Kaczorowski¹, B. Griffith¹, M. Mohiuddin¹
¹Department of Surgery, University of Maryland, Baltimore, MD, ²Revivicor Inc, Blacksburg, WV
*Purpose: Cardiac xenotransplantation (CXTx) is proposed as an alternate treatment for end-stage cardiac failure patients. The prolonged survival of a heterotopic genetically engineered (GE) pig…