Articles tagged "Heart/lung transplantation"

2022 American Transplant Congress
Post Heart Transplant Outcomes of Desensitized Durable Mechanical Circulatory Support Patients
J. Youn¹, D. Kim², J. Choi², K. Kim¹, I. Kim³, E. Kransdorf⁴, D. Chang⁴, M. Kittleson⁴, J. Patel⁴, R. Cole⁴, J. Moriguchi⁴, D. Ramzy⁵, F. Esmailian⁵, J. A. Kobashigawa⁴
¹Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea, Republic of, ²Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea, Republic of, ³Keimyung University Dongsan Hospital, Daegu, Korea, Republic of, ⁴Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, ⁵Department of Cardiothoracic Surgery, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Desensitization therapy (DST) is considered to increase the chances of a negative crossmatch, to expand the number of suitable donors, and to improve post-transplant…
2022 American Transplant Congress
Direct Procurement of Heart and Lungs from a Controlled DCD Donor with Ongoing Abdominal Normothermic Regional Perfusion (aNRP) – A Synchronized Retrieval
M. Husain¹, A. Jothidasan¹, C. Zeschky¹, M. Osman², M. Berman², R. Gaurav³, A. Butler³, C. Watson³, B. Stutchfield⁴, I. Currie⁵, G. Oniscu⁵, J. Dunning¹, U. Stock¹
¹Department of Cardiothoracic Surgery, Transplantation and MCS, Royal Brompton & Harefield Hospitals Part of Guy's and St. Thomas' NHS Foundation Trust, London, United Kingdom, ²Department of Heart and Lung Transplant, Royal Papworth Hospital, Cambridge, United Kingdom, ³Roy Calne Transplant Unit, Department of Surgery, Addenbrookes Hospital, Cambridge University NHS Trust, Cambridge, United Kingdom, ⁴Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh, Edinburgh, United Kingdom, ⁵Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom
*Purpose: With the increased number of aNRP in controlled DCD donors comes a high demand for techniques to directly procure cardiothoracic organs during the aNRP.…
2022 American Transplant Congress
Using mTOR Inhibitor Nanoimmunotherapy to Induce Cardiac Allograft Tolerance in Non-Human Primates
J. M. O¹, P. M. Patel², A. J. Teunissen³, C. L. Miller⁴, T. Costa¹, M. Momodu¹, D. Muldoon¹, A. Dehnadi¹, I. M. Hanekamp¹, V. Pothula⁵, R. Sanchez-Tarjuelo⁶, G. Prevot⁶, W. J. Mulder⁶, J. Allan⁷, J. Ochando⁸, J. Madsen⁹
¹MGH, Boston, MA, ²Emory University, Atlanta, GA, ³Icahn School of Medicine at Mount Sinai, New york, NY, ⁴Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ⁵Icahn School of Medicine at Mount Sinai, New York, NM, ⁶Icahn School of Medicine at Mount Sinai, New York, NY, ⁷Massachusetts General Hospital - Harvard Medical S, Marblehead, MA, ⁸Mount Sinai School of Med, New York, NY, ⁹Massachusetts General Hospital, Boston, MA
*Purpose: Though tolerance of kidney allografts has been consistently achieved using a mixed-chimerism model, cardiac allografts remain resistant to tolerance induction. Lipoprotein-based nanobiologics loaded with…
2022 American Transplant Congress
Pre-Emptive Rituximab Use for Epstein-Barr Virus (EBV) Viremia in Cardiothoracic Solid Organ Transplant Recipients
B. Astorga, A. Loethen, L. Potter
University of Chicago Medicine, Chicago, IL
*Purpose: EBV viremia is associated with potentially life-threatening post-transplant lymphoproliferative disorders (PTLD) after solid organ transplantation. The utility of rituximab for treating EBV viremia in…
2022 American Transplant Congress
Status Exception Use in the New Seven-Tiered Heart Allocation System
A. Plana¹, A. Kanelidis¹, W. F. Parker², V. Jeevanandam³, C. Salerno³, B. Smith¹, S. Kalantari¹, S. Pinney¹, J. Grinstein¹
¹Cardiology, University of Chicago, Chicago, IL, ²Pulmonary/Critical Care, University of Chicago, Chicago, IL, ³Cardiac Surgery, University of Chicago, Chicago, IL
*Purpose: The revised seven-tiered US heart allocation policy aimed to improve risk stratification to lower exception status use. However, recent literature has demonstrated that exceptions…
2022 American Transplant Congress
Dendritic Cell Senescence as a Key Contributor to Transplant Rejection
J. Zhao¹, X. Li¹, S. Jung¹, H. Zhang¹, V. Kasinath¹, J. Azzi¹, P. Sage¹, J. Bromberg², R. Abdi¹
¹Brigham and Women’s Hospital, Boston, MA, ²University of Maryland School of Medicine, Baltimore, MD
*Purpose: Intra-graft inflammation initiated by ischemia-reperfusion injury (IRI) is an unavoidable consequence of transplantation surgery and constitutes a key source of alloimmune responses. IRI leads…
2022 American Transplant Congress
Fontan versus Non-Fontan Combined Heart-Liver Transplantation: Proceed but Cautiously
I. A. Ziogas, W. K. Wu, M. Izzy, A. Shingina, C. Benson, K. L. Mishra, A. S. Shah, N. L. Do, W. G. McMaster, J. N. Menachem, S. P. Alexopoulos
Vanderbilt University Medical Center, Nashville, TN
*Purpose: Combined heart-liver transplantation (CHLT) is increasing, corresponding with a growing prevalence of Fontan-associated end-organ damage. We aimed to describe our contemporary institutional experience with…
2022 American Transplant Congress
Cryptococcal Meningitis Presenting as SIADH in a Heart Transplant Recipient
D. Blake, M. Ibrahim, E. Hamad, V. Rakita, J. Hoosain, H. Clauss
Temple University Hospital, Philadelphia, PA
*Purpose: Cryptococcal meningitis is a potentially fatal invasive fungal infection in solid organ transplant recipients. Meningoencephalitis is the most common clinical manifestation of cryptococcal infection.…
2022 American Transplant Congress
Real-Time Biometric Monitoring Using Wearable Devices for Pediatric Heart Transplant Rejection and Infection Surveillance
D. Gandla¹, J. B. Edelson², E. Mukhtar¹, J. Callanan¹, H. Lad¹, H. Gao¹, J. Cornetta¹, B. Keating¹
¹Department of Surgery, Perelman School of Medicine, Philadelphia, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Monitoring for acute rejection (AR) after orthotopic heart transplantation (OHTx) is primarily achieved by evaluating histological endomyocardial biopsies (EMBx). However, this procedure is limited…
2022 American Transplant Congress
Evaluation of Conversion from Immediate Release (IR) Tacrolimus to LCP-Tacrolimus (Envarsus XR®, LCP) in Heart Transplant Recipients
E. Foster¹, A. Iaria¹, J. Negrelli², M. Fine², M. Yu², M. Liebo²
¹University of Illinois at Chicago, Chicago, IL, ²Loyola University Medical Center, Maywood, IL
*Purpose: The purpose of this study was to assess outcomes in heart transplant recipients who were converted from IR tacrolimus to LCPT. Limited data exists…