2018 American Transplant Congress
Heart Transplant across Low or Moderate Level Donor-Specific Antibodies Have Acceptable Outcome
Cedars Sinai Medical Center, Los Angeles.
Purpose: The presence of pre-transplant donor specific antibodies (DSA) can reduce the likelihood of a patient (pt) obtaining a compatible donor heart. The proportion of…2018 American Transplant Congress
Graft Dendritic Cell p40 Homodimers Activate Donor-Reactive Endogenous Memory CD8 T Cells within Higher Risk Allografts
Immunology, Cleveland Clinic, Cleveland, OH.
Memory T cells with donor-reactivity pose a major barrier to successful allograft transplantation and tolerance induction. Longer cold ischemic storage (CIS) prior to transplantation promotes…2018 American Transplant Congress
Assessing Response to Desensitization: What Makes Sense?
Cedars Sinai Medical Center, Los Angeles.
Purpose: Sensitized candidates experience prolonged waiting times for heart transplant (HT). Desensitization therapies can increase access to HT for sensitized candidates, but changes in calculated…2018 American Transplant Congress
The Utility of a CD31/CD68 Dual Immunohistochemical Stain to Improve Accurate Diagnosis of Antibody Mediated Rejection in Cardiac Transplantation
Thoracic Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
Antibody mediated rejection (AMR) occurs in 10%-20% of cardiac transplant patients and is associated with increased mortality. The endomyocardial biopsy, used to identify microvascular injury…2018 American Transplant Congress
Hemodynamic and Functional Analysis of Human DCD Hearts Undergoing Normothermic Ex Vivo Perfusion
Massachusetts General Hospital, Boston.
Heart donation after circulatory death (DCD) is feasible although little is known about the hemodynamic and functional parameters of these marginal donor organs. We conducted…2018 American Transplant Congress
Providing Actual Echocardiographic Images to Centers Markedly Increases Transplantation of Deceased Donor Hearts
Organ Procurement, Lifesharing of San Diego, San Diego, CA.
US transplant centers are cautious in accepting deceased donor hearts (DDHs). Even in previously healthy, young brain dead donors, wall motion and other echographic abnormalities…2018 American Transplant Congress
Cardiac MRI May Help to Determine When to Refer Heart Transplant Patients for Redo Heart Transplant
Cedars Sinai Medical Center, Los Angeles.
Purpose: Small vessel coronary artery disease is known to cause fibrosis. However, it is not clear whether myocardial fibrosis detected on MRI is associated with…2018 American Transplant Congress
Do Recent Heart Transplant Patients Need to Reside Close to the Transplanting Center? A Look at the Impact of Commuting Times on Clinical Outcomes
Cedars Sinai Medical Center, Los Angeles.
Purpose: Compliance after heart transplantation (HTx) is crucial to ensure adequate drug dosing and avoidance of complications especially within the first six months. To ensure…2018 American Transplant Congress
Incidence of Pneumonitis in Heart Transplant Patients Started on a Proliferation Signal Inhibitor
Cedars Sinai Medical Center, Los Angeles.
Purpose: Proliferation signal inhibitors(PSI) have a high discontinuation rate due to side effects. PSI induced pneumonitis has been reported in 14% in renal cell carcinoma…2018 American Transplant Congress
Macrophage Depletion of RCMV-Latently Infected Allografts Ameliorates Accelerated Chronic Cardiac Rejection
1Abdominal Organ Transplantation, OHSU, Portland, OR; 2VGTI, OHSU, Portland, OR.
PurposeLatent donor rat cytomegalovirus (RCMV) infection accelerates chronic rejection (CR) in a heterotopic rat heart transplant model. RCMV latency is associated with an influx of…
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