2018 American Transplant Congress
The LncRNA MALAT1 Induces Tolerogenic DCs and Antigen Specific Tregs Subsequently Mediating Cardiac Allograft Tolerance in Mice via MiR-155/DC-SIGN/IL10 Axis
Background: Tolerogenic dendritic cells(DCs) by shaping T cells immunity and inducing Tregs play critical roles in the induction of allograft tolerance in transplantation. Long noncoding…2018 American Transplant Congress
p40 Homodimer Induced Proliferation of Endogenous Donor-Reactive Memory CD8 T Cells within High Risk Allografts Requires Memory CD8 T Cell Expression of CD122
Immunology, Cleveland Clinic, Cleveland, OH.
Increasing the duration of cold ischemic storage (CIS) from 0.5 to 8 hrs prior to transplant induces the increased proliferation of endogenous donor-reactive CD4 and…2018 American Transplant Congress
The Continuous Debate of Older Donors into Older Recipients: Another Angle
Cedars Sinai Medical Center, Los Angeles.
Purpose: Heart transplantation (HTx) remains limited by donor availability. Many programs accept older donors (≥50 yrs) for older recipients (≥ 60 yrs) in an effort…2018 American Transplant Congress
Senolytic Drug Treatment Attenuates mtDNA-Mediated Inflammatory Injury in Old Donors and Prolongs Cardiac Allograft Survival
Introduction: Solid organ transplantation has seen a increase in the utilization of older organs. Here, we investigate how aging-associated kinetics of damage associated molecular patterns…2018 American Transplant Congress
Heart Transplant across Low or Moderate Level Donor-Specific Antibodies Have Acceptable Outcome
Cedars Sinai Medical Center, Los Angeles.
Purpose: The presence of pre-transplant donor specific antibodies (DSA) can reduce the likelihood of a patient (pt) obtaining a compatible donor heart. The proportion of…2018 American Transplant Congress
Graft Dendritic Cell p40 Homodimers Activate Donor-Reactive Endogenous Memory CD8 T Cells within Higher Risk Allografts
Immunology, Cleveland Clinic, Cleveland, OH.
Memory T cells with donor-reactivity pose a major barrier to successful allograft transplantation and tolerance induction. Longer cold ischemic storage (CIS) prior to transplantation promotes…2018 American Transplant Congress
Assessing Response to Desensitization: What Makes Sense?
Cedars Sinai Medical Center, Los Angeles.
Purpose: Sensitized candidates experience prolonged waiting times for heart transplant (HT). Desensitization therapies can increase access to HT for sensitized candidates, but changes in calculated…2018 American Transplant Congress
The Utility of a CD31/CD68 Dual Immunohistochemical Stain to Improve Accurate Diagnosis of Antibody Mediated Rejection in Cardiac Transplantation
Thoracic Pathology, University of Texas Southwestern Medical Center, Dallas, TX.
Antibody mediated rejection (AMR) occurs in 10%-20% of cardiac transplant patients and is associated with increased mortality. The endomyocardial biopsy, used to identify microvascular injury…2018 American Transplant Congress
Hemodynamic and Functional Analysis of Human DCD Hearts Undergoing Normothermic Ex Vivo Perfusion
Massachusetts General Hospital, Boston.
Heart donation after circulatory death (DCD) is feasible although little is known about the hemodynamic and functional parameters of these marginal donor organs. We conducted…2018 American Transplant Congress
Providing Actual Echocardiographic Images to Centers Markedly Increases Transplantation of Deceased Donor Hearts
Organ Procurement, Lifesharing of San Diego, San Diego, CA.
US transplant centers are cautious in accepting deceased donor hearts (DDHs). Even in previously healthy, young brain dead donors, wall motion and other echographic abnormalities…
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