Articles tagged "Heart/lung transplantation"

2018 American Transplant Congress
Cardiac Grafts from Insulin Resistant Donors Trigger a Heightened Immune Response via Excessive Induction of Autophagy
S. Cai,¹ J. Miao,² A. Chandraker.¹
¹Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA; ²Division of Endocrinology, Boston Children's Hospital, Boston, MA.
Background Heart transplantation remains the treatment of choice for many patients with medically refractory heart failure. The use of organs from patients with insulin resistant…
2018 American Transplant Congress
Influence of Dendritic Cell Subsets on Enhancing Oral Tolerance in Cardiac Transplantation Model
G. Gu, T. Lu, N. Xu, Q. Xia.
Department of Liver Surgery, Renji Hospital, Affiliated by Shanghai Jiaotong University Medical School, Shanghai, China.
Oral tolerance has been implicated in the protection of transplant rejection in the animal models. Antigen presenting cells (APCs) are responsible for sampling their environment…
2018 American Transplant Congress
IL-10 Requirement in In Vitro Expanded Breg-Mediated Allograft Tolerance is Tissue Specific
C. Dai, K. Lee, L. Kojima, K. Deng, S. Kimura, C. Rickert, H. Yeh, J. Markmann.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Introduction:Regulatory B cells (Bregs) have shown several multiple mechanisms of suppression, including Treg induction and IL-10 production. Consistent with work of other groups on Breg…
2018 American Transplant Congress
CD8-Expressing Transitional B Cells Dominate B Cell Reconstitution in Transplanted Monkeys Receiving Mixed Chimerism Conditioning
K. Pruner, J. Paster, S. Wiebke, O. Jane, H. Isabel, D. Abbas, B. Gilles, M. Joren.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
IntroductionTolerance of heart or lung allografts have been achieved for the first time in nonhuman primates (NHPs) using a mixed chimerism conditioning regimen. However, the…
2018 American Transplant Congress
Long Noncoding RNA NEAT1 Induces Tolerogenic Dendritic Cells in Heart Transplantation
J. Wu,^1,2 Y. Zheng,^1,2 S. Li,^1,2 M. Zhang,^1,2 H. Zhang,^1,2 X. Zheng,^1,2 Y. Sun,^1,2 B. Yu.^1,2
¹Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China; ²The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Purpose: Tolerogenic dendritic cells have been gaining interest as an efficient means of promoting antigen-specific tolerance in organ transplantation. Long noncoding RNA NEAT1 plays an…
2018 American Transplant Congress
Potential Impact of DCD Donor Recoveries on Heart Transplantation: Retrospective Analysis of a Limited UNOS Dataset
J. Lindower,² M. Farr,¹ S. Taylor,² U. Jorde,³ L. Chen,⁴ A. Gass,⁵ L. Truby,¹ S. Delair,² S. Pinney.⁶
¹New York Cardio-Thoracic Transplant Consortium, Troy, NY; ²Columbia/New York Presbyterian Hospital, New York; ³Montefiore Medical Center, Bronx, NY; ⁴Rochester University Medical Center, Rochester, NY; ⁵Westchester Medical Center, Valhalla, NY; ⁶Mount Sinai Medical Center, New York, NY.
Purpose: To review the volume and quality of potential DCD (Donation after Cardiac Death) Heart Transplant (HT) donors in the US, evaluate trends over time…
2018 American Transplant Congress
Heart En Bloc Thymus Cotransplantation in NHPs Controls Cellular but Not Humoral Alloreactivity
W. Sommer, J. O., K. Pruner, J. Paster, M. Hanekamp, A. Dehnadi, I. Rosales, R. Smith, R. Colvin, G. Benichou, J. Allan, J. Madsen.
Massachusetts General Hospital, Boston.
Background: We have achieved tolerance of cardiac allografts in Cynomolgus monkeys for the first time by using a mixed chimerism-based conditioning protocol and by co-transplanting…
2018 American Transplant Congress
α-1 Antitrypsin Facilitate Apoptosis Donor Cells Inducing Donor Specific Protection to Mice Cardiac Allografts
G. Chen, X. Lai, L. Qiu, Y. Zhao, S. Yu, C. Wang, J. Zhang, F. Ning, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Previous study has shown that intravenous infusion of ethylene carbodiimide fixed donor splenocytes(ECDI-SPs) can induce tolerance of mice cardiac allografts with rapidly apoptosis of ECDI-SPs…
2018 American Transplant Congress
The LncRNA MALAT1 Induces Tolerogenic DCs and Antigen Specific Tregs Subsequently Mediating Cardiac Allograft Tolerance in Mice via MiR-155/DC-SIGN/IL10 Axis
M. Zhang,^1,2 J. Wu,^1,2 H. Zhang,^1,2 M. Liu,^1,2 Y. Zheng,^1,2 X. Jin,^1,2 S. Li,^1,2 Q. Zhao,^1,2 X. Liu,^1,2 Y. Sun,^1,2 B. Yu.^1,2
¹Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China; ²The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, Heilongjiang, China.
Background: Tolerogenic dendritic cells(DCs) by shaping T cells immunity and inducing Tregs play critical roles in the induction of allograft tolerance in transplantation. Long noncoding…
2018 American Transplant Congress
p40 Homodimer Induced Proliferation of Endogenous Donor-Reactive Memory CD8 T Cells within High Risk Allografts Requires Memory CD8 T Cell Expression of CD122
H. Tsuda, A. Valujskikh, R. Fairchild.
Immunology, Cleveland Clinic, Cleveland, OH.
Increasing the duration of cold ischemic storage (CIS) from 0.5 to 8 hrs prior to transplant induces the increased proliferation of endogenous donor-reactive CD4 and…