Articles tagged "Heart/lung transplantation"

2019 American Transplant Congress
Characterization of Circulating T-cell Specific Exosomes during Acute Rejection in Murine Heart Transplantation Model
R. Hu¹, V. Korutla¹, L. Korutla¹, S. Rostami¹, A. Habertheuer¹, S. Addya², J. Harmon¹, P. Zielinski¹, S. Reddy¹, A. Freas¹, C. Ram¹, A. Naji¹, P. Vallabhajosyula¹
¹Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, ²Thomas Jefferson University, Philadelphia, PA
*Purpose: Exosomes are nanoparticles (30-200nm) released by many cell types. They carry nucleic acid and proteins that may reflect conditional changes in their tissue counterparts.…
2019 American Transplant Congress
Prolonged Heterotopic Cardiac Xenograft Survival from Thrombomudulin Expressing Multigene Donor Pig
A. K. Singh¹, L. DiChiacchio¹, T. Zhang¹, A. Hersfield¹, I. Tatarov¹, D. Parsell¹, B. Lewis¹, F. Sentz¹, D. Ayares², M. Mohiuddin¹
¹Department of Surgery, University of Maryland Baltimore, Baltimore, MD, ²Revivicor, Inc, Blacksburg, VA
*Purpose: Genetic engineering (GE) technology has made knockout and multigene expressing animals available. These animals can be used for xenotransplantation (xTX)to treat end stage diseases.…
2019 American Transplant Congress
Increasing Doses of Pain Medications Pre-Heart Transplant as a Risk Factor for Outcomes after Transplant
K. Shah, D. H. Chang, J. Patel, R. J. Levine, S. Dimbil, E. Passano, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Chronic pain syndromes prior to heart transplantation (HTx) are not uncommon. However, the use of morphine equivalents in higher doses may be indicative of…
2019 American Transplant Congress
Anti-CD272 Antibody (6B2) Induced Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allograft
E. Yin, M. Uchiyama, Y. Yamamoto, M. Niimi
Teikyo University, Tokyo, Japan
*Purpose: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA; CD272) has been implicated in the regulation of autoimmune and may potentially play an important…
2019 American Transplant Congress
Amiodarone And Primary Graft Dysfunction In Heart Transplantation: Reality Or Myth?
M. Kittleson, J. Patel, D. H. Chang, E. Kransdorf, S. Dimbil, R. Levine, K. Yabuno, L. Czer, M. Hamilton, F. Esmailian, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Primary graft dysfunction (PGD) after heart transplantation (HTx) is seen in approximately 10-30% of patients immediately post-transplant. The cause of PGD is not clear…
2019 American Transplant Congress
Safety and Efficacy of Anti Xa Inhibitors Post-Transplant with Concomitant Calcineurin Inhibitors
K. A. McMurry¹, J. Shuster², K. Bain², T. Horwedel³, J. Hartupee²
¹Michigan Medicine, Ann Arbor, MI, ²Barnes-Jewish Hospital, St. Louis, MO, ³Veloxis Pharmaceuticals, Cary, NC
*Purpose: Despite demonstrated benefits of Anti-Xa Inhibitors (ATIs) in the general population, ATIs have not gained uniform acceptance in SOT due to lack of supportive…
2019 American Transplant Congress
Incidence and Risk of Allograft Rejection after Cardiac Transplantation in Left Ventricular Assist Device Patients
R. C. Patel¹, L. B. Cooper², S. D. Barnett², R. T. Cole², M. A. Psotka², A. Cochrane², S. Sinha², L. J. Bogar², S. S. Desai², P. Shah²
¹Virginia Commonwealth University School of Medicine, Inova Fairfax Hospital, Falls Church, VA, ²Department of Heart Failure and Transplant, Inova Heart and Vascular Institute, Falls Church, VA
*Purpose: Left ventricular assist devices (LVAD) are made of biomaterials that have been shown to cause allosensitization. Single center studies have suggested that patients bridged…
2019 American Transplant Congress
3-year Outcome Of Heart Transplantation In Patients With Amyloidosis
J. Patel, M. Kittleson, D. H. Chang, R. Levine, S. Dimbil, L. Czer, F. Esmailian, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Both amyloid light chain (AL) amyloidosis and transthyretin-related (TTR) amyloid are expanding indications for heart transplantation (HTx). In the past, AL amyloid, in particular,…
2019 American Transplant Congress
Correlation between Self-Reported Medication Adherence and Side Effects in Transplant Recipients
T. Harrison¹, K. Foster¹, N. Patel¹, H. Meadows¹, C. Perez¹, H. Corbo¹, J. Fleming¹, N. Pilch¹, D. DuBay², J. McGillicuddy², S. Nadig², V. Rohan², D. Taber¹
¹Pharmacy Services, Medical University of South Carolina, Charleston, SC, ²Transplant Surgery, Medical University of South Carolina, Charleston, SC
*Purpose: Medication non-adherence (MNA) is a major risk factor for acute rejection and graft loss amongst all organ groups. It is unclear how medication side…
2019 American Transplant Congress
Does the Type of Pre-Heart Transplant Desensitization Therapy Affect 5-Year Post-Transplant Outcomes?
J. Patel, E. Kransdorf, R. Levine, S. Dimbil, L. Czer, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: As many patients with severe heart disease require mechanical circulatory support (MCS), the number of sensitized patients developing circulating antibodies continues to rise. In…