Articles tagged "Heart/lung transplantation"

2019 American Transplant Congress
IL-1β and IL-6 Facilitate T Cell Reconstitution in Heart Allograft Recipients Treated with Anti-Thymocyte Globulin
S. Hasgur, R. Fan, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Antibody-mediated lymphocyte depletion is used in solid organ and stem cell transplantation. However, T cell reconstitution after lymphoablation may lead to acute rejection and…
2019 American Transplant Congress
Anti-Complement Component 5 Antibody Based Immunosuppression Induced Accommodation in ABO Incompatible Heart Transplantation
S. Park¹, S. Lee¹, J. Hwang¹, J. Ryu², T. Koo², C. Ahn³, J. Yang⁴
¹Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of, ²Transplantation Center, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Surgery, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Plasmapheresis in combination with immunoglobulin and rituximab is often used to induce accommodation in ABO-incompatible (ABOi) living-donor transplantation; however, this regimen cannot be applied…
2019 American Transplant Congress
Heart-Associated Cytokine and Endothelial Patterns Dominate the Ischemia/Reperfusion Response in Recipients of Combined Heart/Lung Transplantation in Comparison to Lung Transplantation
F. Wandrer¹, B. Wiegmann², N. Ledwoch¹, R. Bellmas Sanz¹, F. Ius², W. Sommer², S. Rojas², C. Kühn², I. Tudorache², M. Avsar², A. Haverich², G. Warnecke², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation (Tx) but rarely compared directly in a clinical setting. Therefore, we compared a…
2019 American Transplant Congress
Treprostinil as a Bridge Therapy to Heart-Lung Transplants with Severe Pulmonary Arterial Hypertension
C. Ju, Q. Lian, B. Wei, X. Xu, J. He, R. Chen
State Key Lab of the Respiratory Disease, Guangzhou Institute of Respiratory Disease, Guangzhou, China
*Purpose: Heart-lung transplants (HLTx) is the only one effective strategy for advanced pulmonary arterial hypertension (PAH) with refractory right heart failure. But limited availability of…
2019 American Transplant Congress
Characterization of Intra-Exosomal Cargoes of Circulating Donor Heart Specific Exosomes in Murine Heart Transplantation Model
J. Harmon, V. Korutla, L. Korutla, R. Hu, S. Rostami, A. Habertheuer, P. Zielinski, A. Freas, C. Ram, A. Naji, M. Davis, P. Vallabhajosyula
Department of Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: Exosomes are tissue specific, bilayered, membrane-bound nanoparticles released by many types of cells into bodily fluids including blood and urine. Exosomes carry protein and…
2019 American Transplant Congress
Pre-Transplant Patient and Caregiver Assessments: A Systematic Review and Meta-Analysis
J. Lau, A. A. Rmilah, R. Mendpara, P. J. Erwin, C. C. Kennedy
Mayo Clinic, Rochester, MN
*Purpose: We sought to summarize the available literature regarding the psychosocial effects of the waiting period on pre-transplant adult heart or lung transplant candidates and…
2019 American Transplant Congress
Erk-elk1-mir-711 Signalling In Cardiac Ischemia Reperfusion Injury In Heart Transplantation
H. Zheng, Y. Su, C. Zhu, V. Veramkovich, X. Zheng
Pathology, University of Western Ontario, London, ON, Canada
*Purpose: This study aims to discover new molecular mechanisms involved in and to develop new treatment for preventing ischemia reperfusion injury in heart transplantation.*Methods: The…
2019 American Transplant Congress
QA of MMR/VZV Protocol-Driven Serologic Screening and Infectious Disease Consultation (IDC) Are Strongly Recommended in Heart, Lung, Liver (HLL) SOTs
Z. Seckin, L. Brumble, C. Libertin
Mayo Clinic, Jacksonville, FL
*Purpose: SOT recipients are at risk of acquiring life-threatening infections putting their graft and life at risk. Prevention, including immunization with live virus vaccines pre-transplantation…
2019 American Transplant Congress
Characterization of Circulating T-cell Specific Exosomes during Acute Rejection in Murine Heart Transplantation Model
R. Hu¹, V. Korutla¹, L. Korutla¹, S. Rostami¹, A. Habertheuer¹, S. Addya², J. Harmon¹, P. Zielinski¹, S. Reddy¹, A. Freas¹, C. Ram¹, A. Naji¹, P. Vallabhajosyula¹
¹Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, ²Thomas Jefferson University, Philadelphia, PA
*Purpose: Exosomes are nanoparticles (30-200nm) released by many cell types. They carry nucleic acid and proteins that may reflect conditional changes in their tissue counterparts.…
2019 American Transplant Congress
Prolonged Heterotopic Cardiac Xenograft Survival from Thrombomudulin Expressing Multigene Donor Pig
A. K. Singh¹, L. DiChiacchio¹, T. Zhang¹, A. Hersfield¹, I. Tatarov¹, D. Parsell¹, B. Lewis¹, F. Sentz¹, D. Ayares², M. Mohiuddin¹
¹Department of Surgery, University of Maryland Baltimore, Baltimore, MD, ²Revivicor, Inc, Blacksburg, VA
*Purpose: Genetic engineering (GE) technology has made knockout and multigene expressing animals available. These animals can be used for xenotransplantation (xTX)to treat end stage diseases.…