Articles tagged "Heart/lung transplantation"

2019 American Transplant Congress
Geographic Disparities in Heart Transplant Rates
M. Kosztowski, S. Yu, A. Kilic, A. Massie, S. Zhou, D. Segev, S. Gentry
JHU, Baltimore, MD
*Purpose: One of the motivations for the recent changes to the heart allocation policy was to reduce geographic disparities. We investigated whether heart transplant (HT)…
2019 American Transplant Congress
Do Heart Transplant Patients Have Support Personnel Ready to Help Them If Necessary?
A. Velleca, K. Norland, M. Curry, N. Ransbottom, B. Kearney, R. Levine, S. Dimbil, R. Sharoff, E. Passano, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: After heart transplantation (HTx), we mandate that each patient have social support in the first several weeks. It is not known whether these support…
2019 American Transplant Congress
Heart En Bloc Thymus Cotransplantation in NHPs
J. O¹, W. Sommer², K. Pruner³, J. T. Paster⁴, I. M. Hanekamp¹, A. Dehnadi¹, I. Rosales¹, R. N. Smith¹, R. B. Colvin¹, G. Benichou¹, J. S. Allan¹, J. C. Madsen¹
¹Center for Transplantation Sciences, MGH, Boston, MA, ²Hannover Medical School, Hannover, Germany, ³University of Washington, Seattle, WA, ⁴MGH, Boston, MA
*Purpose: Tolerance of isolated cardiac allografts has never been achieved in NHPs. We investigated whether a cotransplanted, vascularized, donor thymus could induce tolerance of a…
2019 American Transplant Congress
Risk Factors to Define an Extended Criteria Donor Heart Do Not Appear to Have Cumulative Adverse Effects after Heart Transplantation
M. Olymbios, S. Dimbil, R. J. Levine, F. Esmailian, J. Patel, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: There remains a disparity between the number of patients awaiting heart transplantation (HTx) and the availability of donor hearts. This is exacerbated by relatively…
2019 American Transplant Congress
Infectious Risk of Rejection Therapy Following Heart Transplantation; Can It Be Avoided?
M. Kittleson, J. Patel, S. Dimbil, R. J. Levine, G. Esmailian, A. Shen, T. Hage, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: The diagnosis of rejection after heart transplantation (HTx) is usually based on the surveillance endomyocardial biopsies (EMB). These protocol biopsies are performed at scheduled…
2019 American Transplant Congress
Circulating Exosomes with Cardiac Self-Antigens (Cardiac Myosin and Vimentin) and De Novo Development of Antibodies to Cardiac Self-Antigens Precedes Chronic Cardiac Allograft Rejection
R. Ravichandran, Y. Itabashi, W. Liu, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The aim of the study is to determine the kinetics of induction of circulating exosomes with cardiac self-antigens (SAgs), cardiac myosin (MYO) and Vimentin…
2019 American Transplant Congress
p40 Homodimer Indirectly Induce Proliferation of Endogenous Donor-Reactive Memory CD8 T Cells within High-Risk Allografts via IL-15 Signaling
H. Tsuda, A. Valujskikh, R. Fairchild
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Increasing the duration of cold ischemic storage (CIS) from 0.5 to 8 hrs prior to transplant induces the increased proliferation of endogenous donor-reactive CD4…
2019 American Transplant Congress
Extracorporeal Photopheresis for Specific Immune Tolerance Responses in Heart Transplant Recipients
M. J. Barten¹, K. Klaeske², J. Wittke², M. Borger², J. Garbade², S. Lehmann³, H. Reichenspurner¹, M. Dieterlen²
¹Cardiovascular Surgery, University Heart Center, Hamburg, Germany, ²Cardiac Surgery, University Heart Center Leipzig, Leipzig, Germany, ³Cardiacr Surgery, University Heart Center Leipzig, Leipzig, Germany
*Purpose: Extracorporeal photopheresis (ECP) treatment following heart transplantation (HTx) may induce transplant tolerance. A monitoring tool for successful ECP treatment would allow determination of patient-specific…
2019 American Transplant Congress
Graft-Infiltrating Regulatory T Cells Are Associated with Long Term Cardiac Xenograft Survival
A. K. Singh¹, G. Braileanu¹, A. Hersfield¹, L. DiChiacchio¹, T. Zhang¹, I. Tatarov¹, D. Parsell¹, B. Lewis¹, F. Sentz¹, D. Ayares², M. Mohiuddin¹
¹Department of Surgery, School of Medicine, University of Maryland Baltimore, Baltimore, MD, ²Revivicor, Inc, Blacksburg, VA
*Purpose: Regulatory T (CD4+CD25HiFoxP3+) cells (Treg) are a very small subset of CD4+ T cells that have been shown to play an important role in…
2019 American Transplant Congress
MDSCs Prolong Allogeneic Cardiac Graft Survival by Regulating Interferon Type 1 Signaling
S. Cai¹, P. T. Sage¹, T. J. Borges¹, T. Ichimura¹, S. K. Eskandari¹, J. Y. Choi¹, I. Salkuj¹, B. S. AI Dulaijan¹, H. Allos¹, J. Miao², L. V. Riella¹, A. K. Chandraker¹, J. R. Azzi¹
¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Boston Children's Hospital, Harvard Medical School, Boston, MA
*Purpose: We previously demonstrated that donor-derived regulatory dendritic cells (DCreg), contrary to recipient derived DCreg, promote antigen-specific allograft protection. As myeloid-derived suppressor cells (MDSC) show…