2020 American Transplant Congress
Circulating Exosomes with Cardiac Self-Antigens, Myosin and Vimentin, Induced Immune Responses Leading to Rejection Following Heterotopic Cardiac Transplantation Immunosuppressed with mTOR Inhibitor and Low Dose of IL-2 Therapy
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: The aim of the study is to determine the role for circulating exosomes with cardiac self-antigens (SAgs) (Myosin, Vimentin) in the development of immune…2020 American Transplant Congress
Successful Heart Utilization and Outcomes with Long-Distance Transport of Deceased Donor Hearts: One Large Organ Procurement Organization’s Five-Year Experience
LifeCenter Northwest, Bellevue, WA
*Purpose: Long-distance transport of deceased donor hearts has been associated with reduced organ utilization rates and risk of inferior outcomes. One U.S. Organ Procurement Organization’s…2020 American Transplant Congress
Role of Circulating Exosomes in the Induction of Immune Responses Resulting in Cardiac Allograft Rejection in miR155 Knockout Animals
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Our goal is to define the mechanism by which circulating exosomes with cardiac self-antigens (SAgs), Myosin, Vimentin, and angiotensin Receptor 1 Protein (AGTR1) leads…2020 American Transplant Congress
Evaluation of Oral Candidiasis Incidence at Large Academic Medical Center in Absence of Pharmacologic Prophylaxis at Discharge
*Purpose: Oral candidiasis (OC) is a common complication in solid organ transplant recipients. Despite AST guidelines recommending against universal prophylaxis, it has become common practice…2020 American Transplant Congress
Impact of Dialysis and Diabetes on Survival in Recipients of Combined Heart-Kidney Transplant
*Purpose: Mounting data shows a survival benefit of combined heart-kidney transplantation in patients with heart and renal failure. However, little has been done to understand…2020 American Transplant Congress
Cardiac Transplantation is Accompanied by Major T and NK Cell Alterations within the First 24 Hours
*Purpose: Allogeneic heart transplantation (HTx) displays the only curative approach for terminal heart insufficiency while acute allograft rejection remains a major complication. However, early kinetics…2020 American Transplant Congress
Is Ischemia Reperfusion Injury Immediately after Heart Transplantation Correlated to Increased Intimal Thickening in the First Year?
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Ischemia reperfusion injury (IRI) is not uncommon in heart transplant patients due to high dose inotropes, ischemic time, and technical surgical reasons. Ischemia in…2019 American Transplant Congress
What Are You Smoking? The Impact of Donor Drug Use on Long Term Survival Post-Transplant
*Purpose: Drug use is a common aspect in the history of heart transplant donors. Whether prior or current drug use is associated with inferior post…2019 American Transplant Congress
Slowed Progression of Maximal Intimal Thickening by Intravascular Ultrasound after Initiation of Sirolimus
1Children's Hospital Colorado, Aurora, CO, 2University of Florida Health, Gainesville, FL
*Purpose: Evidence in adult heart transplant (HT) patients (pt) shows that initiating sirolimus (SRL) slows progression of cardiac allograft vasculopathy (CAV) measured by intravascular ultrasound…2019 American Transplant Congress
A Novel Protocol to Produce Massive Amounts of Autologous Thymus-Derived Treg Cells (ThyTreg) to Be Employed as Cellular Therapy in Heart Transplanted Children: A New Paradigm for the Prevention of Graft Rejection
*Purpose: Immune allograft rejection remains the main obstacle to successful transplants. Although transfer of regulatory T cells (Treg) has acquired growing interest in achieving indefinite…
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