Articles tagged "Heart/lung transplantation"

2020 American Transplant Congress
Is 3-4+ Liver Fibrosis a Contraindication to Heart Transplantation?
M. Kittleson, J. Patel, D. Chang, E. Kransdorf, D. Geft, K. Nishihara, A. Shen, B. May, L. Czer, F. Esmailian, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Chronic liver disease in patients awaiting heart transplant is seen in patients with biventricular heart failure. This is mostly due to congestive hepatopathy due…
2020 American Transplant Congress
Anti-Thymocyte Globulin Promotes Tfh Cells Differentiation and Alloantibody Production
R. Benedetti Gassen, B. Aoyama, M. Lima, T. Borges, M. Pérez-Sáez, N. Murakami, P. Sage, J. Pascual, L. V. Riella
Transplantation Research Center, Brigham and Women's Hospital, Boston, MA
*Purpose: Antibody-mediated rejection is a major cause of long-term graft loss. T follicular helper (Tfh) cell is CD4+ T cell subset that is specialized in…
2020 American Transplant Congress
Foxp3⁺ Innate and TGF-ß⁺ Adaptive Regulatory Immune Cells in Quilty Lesions are Associated with Acceptance of Heart Allograft
S. A. Moore, C. K. Metter, Q. Cai, J. R. Torrealba
University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: To evaluate the cellular composition of Quilty lesions in heart transplant biopsies and their association with acceptance or rejection of cardiac allografts.*Methods: This study…
2020 American Transplant Congress
Heart Transplant Outcomes for Patients with Left Ventricular Assist Devices (LVAD) Before and after the 2018 Revision of the United Network for Organ Sharing (UNOS) Adult Heart Allocation System
J. Pizula¹, K. Yang¹, J. Li¹, S. Shah¹, G. Liu¹, A. Lee¹, P. Banankhah¹, J. Nattiv¹, D. Miklin¹, P. Genyk¹, P. Kingsford¹, K. Pandya¹, R. Joeseph¹, M. Fong¹, G. Luanda¹, A. Kiankhooy¹, S. Hashmi¹, S. Nuno¹, A. Wolfson², A. Salimbangon³, R. Chand⁴, D. Vucicevic⁵, L. Corey⁶, E. Depasquale¹, A. Vaidya¹
¹Cardiology, LAC-USC, Los Angeles, CA, ²University of Arizona Sarver Heart Center, Tuscon, AZ, ³UCLA Medical Center, Los Angeles, CA, ⁴Harbor-UCLA Medical Center, Los Angeles, CA, ⁵Newark Beth-Israel Medical Center, Newark, NJ, ⁶The Queen's Medical Center, Honolulu, HI
*Purpose: In October of 2018 UNOS chaged their adult heart allocation criteria to address disparity in waiting list survival. The implications of this policy change…
2020 American Transplant Congress
Recipient Expression of C-Type Lectin Receptor Mincle Promotes Rapid T Cell Homeostatic Recovery Following Antibody Mediated Lymphoablation
S. Hasgur, R. Fan, A. Valujskikh
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Antibody-mediated lymphocyte depletion is widely used in transplantation. We recently established that T cell recovery in mouse heart allograft recipients treated with anti-thymocyte globulin…
2020 American Transplant Congress
Heart Transplantation Outcomes in Patients with Marfan Syndrome: A UNOS Registry Analysis
P. Genyk¹, K. Yang¹, J. Pizula¹, A. Lee¹, D. Miklin¹, S. Shah¹, S. Nuno¹, S. Hashmi¹, J. Nattiv¹, A. Kiankhooy¹, L. Grazette¹, M. Fong¹, J. Rahman¹, K. Pandya¹, A. Vaidya¹, D. Vucicevic², J. Li¹, P. Kingsford¹, P. Banankhah¹, A. Wolfson³, G. Liu¹, R. Chand⁴, E. Depasquale¹
¹Keck Medicine of USC, Los Angeles, CA, ²Newark Beth-Israel Medical Center, Newark, NJ, ³University of Arizona Sarver Heart Center, Tucson, AZ, ⁴Harbor-UCLA Medical Center, Torrance, CA
*Purpose: Marfan syndrome (MS) is an autosomal dominant connective tissue disorder due to a defect in the fibrillin-1 gene. MS patients can develop a discrete…
2020 American Transplant Congress
Bilateral Lung Transplantation Combined with Cardiac Correction in Treatment of Severe Pulmonary Arterial Hypertension Complicated with Eisenmenger Syndrome in Puerpera, a Feasible Strategy for Future?
J. Huang, Z. Wang, J. Chen
Wuxi Lung Transplant Center, Wuxi People's Hospital affiliated to Nanjing Medical University, Wuxi, China
*Purpose: Though pregnancy is not recommended for patients with pulmonary arterial hypertension (PAH) in current guidelines, some patients do stick to parturition due to varies…
2019 American Transplant Congress
MDSCs Prolong Allogeneic Cardiac Graft Survival by Regulating Interferon Type 1 Signaling
S. Cai¹, P. T. Sage¹, T. J. Borges¹, T. Ichimura¹, S. K. Eskandari¹, J. Y. Choi¹, I. Salkuj¹, B. S. AI Dulaijan¹, H. Allos¹, J. Miao², L. V. Riella¹, A. K. Chandraker¹, J. R. Azzi¹
¹Brigham and Women's Hospital, Harvard Medical School, Boston, MA, ²Boston Children's Hospital, Harvard Medical School, Boston, MA
*Purpose: We previously demonstrated that donor-derived regulatory dendritic cells (DCreg), contrary to recipient derived DCreg, promote antigen-specific allograft protection. As myeloid-derived suppressor cells (MDSC) show…
2019 American Transplant Congress
Intravenous Methamphetamine Does Not Appear To Be A Contraindication For Heart Donation In Heart Transplantation
A. Velleca, J. Patel, M. Kittleson, R. Levine, S. Dimbil, S. Mersola, M. Hamilton, F. Esmailian, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Intravenous methamphetamine (IV meth) use in potential heart donors has been of concern due to the possibility of methamphetamine cardiomyopathy and transmission of infections.…
2019 American Transplant Congress
Perioperative Cardiac Xenograft Dysfunction after Orthotopic Transplantation is for Real
M. Mohiuddin¹, A. Singh¹, L. DiChiacchio¹, D. Kaczorowski¹, B. Lewis¹, T. Zhang¹, F. Sentz¹, I. Tatarov¹, D. Parsell¹, P. Odonkor¹, E. Strauss¹, B. Williams¹, K. Deatrick¹, D. Ayares², B. Griffith¹, S. Bartlett¹
¹Department of Surgery, University of Maryland Baltimore, Baltimore, MD, ²Revivicor, Inc, Blacksburg, VA
*Purpose: After successful prolongation of cardiac xenograft survival in a heterotopic position, the next step is to evaluate genetically engineered (GE) pig hearts for their…

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