Articles tagged "Heart"

2021 American Transplant Congress
Changes to Adult Heart Allocation Improve Candidate Stratification
K. Bradbrook¹, K. Lindblad¹, R. R. Goff¹, R. Daly², S. Hall³
¹Research, United Network for Organ Sharing, Richmond, VA, ²Mayo Clinic, Rochester, MN, ³Baylor University Medical Center, Dallas, TX
*Purpose: Historically, heart allocation has been driven by waitlist (WL) mortality rather than post-transplant survival. On 10/18/2018 the Organ Procurement and Transplantation Network (OPTN) implemented…
2021 American Transplant Congress
DSA is Associated with Molecular Changes in Many Hearts with Minor Abnormalities but Not Diagnosed as Antibody-Mediated Rejection
P. Halloran¹, K. S. Madill-Thomsen¹, &. the INTERHEART Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: We previously developed a microarray-based diagnostic system (MMDx) for heart transplant endomyocardial biopsies, measuring gene expression and interpreting antibody-mediated and T cell-mediated rejection (ABMR,…
2021 American Transplant Congress
Cd4 T Cells Can Trigger Nk-dependent Chronic Rejection Independent of Antibodies
R. G. Gill¹, B. Mehrad², C. M. Lin²
¹Surgery, University of Colorado Denver, Aurora, CO, ²Medicine, University of Florida, Gainesville, FL
*Purpose: In transplantation, recipient CD4+ T cells have two potential means of MHC class II-restricted donor antigen detection: (1) the direct recognition of allogeneic MHC…
2021 American Transplant Congress
Change in Deceased Donor Demographics with Drug Intoxication Deaths: 2010 – 2019
D. Musgrove, D. Zaun, A. Israni, J. Snyder
SRTR, Minneapolis, MN
*Purpose: To understand the demographic change in deceased donor causes of death associated with drug intoxication, we explored trends over the 10-year period ending in…
2021 American Transplant Congress
Pig Orthotopic Heart Transplantation (ohtx) in Baboons: Is an Acute Pulmonary Inflammatory Response the Key Problem?
A. Jagdale¹, D. Cleveland², M. Bikhet¹, J. Foote³, G. Walcott⁴, H. Iwase¹, T. Yamamoto¹, H. Hara¹, C. Hansens-Estruch¹, D. Ayares⁵, S. Litovsky⁶, L. Rhodes², W. Carlo⁷, J. Crawford², R. Dabal², S. Borasino², D. Cooper¹
¹Surgery, University of Alabama at Birmingham, Birmingham, AL, ²Cardiothoracic Surgery, Children's of Alabama, Birmingham, AL, ³Medicine and Cardiovascular Diseases, University of Alabama at Birmingham, Birmingham, AL, ⁴Medicine, University of Alabama at Birmingham, Birmingham, AL, ⁵Surgery, Revivicor, Blacksburg, VA, ⁶Pathology, University of Alabama at Birmingham, Birmingham, AL, ⁷Division of Pediatric Cardiology, Department of Pediatrics, University of Alabama at Birmingham, Children's of Alabama, Birmingham, AL
*Purpose: To investigate the mechanism of early cardio-pulmonary dysfunction after genetically engineered pig OHTx in baboons.*Methods: OHTx from pigs expressing different genetic modifications, α‐galactosyltransferase knockout…
2021 American Transplant Congress
Predicted Heart Mass Difference as a Risk Factor for Severe Primary Graft Dysfunction in the Contemporary Era of Heart Transplantation: A Report from the International Consortium on Primary Graft Dysfunction
F. Foroutan¹, L. K. Truby², Y. Moayedi¹, J. Han³, J. Guzman⁴, M. Farrero⁴, E. Baughan⁵, M. Farr⁵, H. Zafar⁶, J. Felius⁶, J. van Zyl⁷, D. Law⁸, S. Chih⁸, P. Angleitner⁹, M. Sabatino¹⁰, A. DeVore², R. J. Miller¹¹, L. Potena¹⁰, A. Zuckermann⁹, K. K. Khush³, S. A. Hall⁶, H. J. Ross¹
¹Ted Rogers Centre for Heart Research, Toronto, ON, Canada, ²Duke University School of Medicine, Durham, NC, ³Stanford University, Stanford, CA, ⁴Clinic Barcelona Hospital Universitari, Barcelona, Spain, ⁵Columbia University Medical Center, New York, NY, ⁶Baylor University Medical Center, Dallas, TX, ⁷Dallas University Medical Center, Dallas, TX, ⁸University of Ottawa Heart Institute, Ottawa, ON, Canada, ⁹Medical University of Vienna, Vienna, Austria, ¹⁰Bologna University Hospital, Bologna, Italy, ¹¹University of Calgary, Calgary, AB, Canada
*Purpose: Primary Graft Dysfunction (PGD) increases early mortality after heart transplant (HT). Predicted heart mass (PHM) difference may be a risk factor for PGD. Lack…
2021 American Transplant Congress
A Novel Mouse Model of Cardiac Allograft Vasculopathy
H. Tsuda¹, E. Reed², W. Baldwin¹, R. Fairchild¹
¹Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, ²Pathology and Laboratory Medicine, University of California, Los Angeles, CA
*Purpose: Cardiac allograft vasculopathy (CAV) is a major long-term complication of heart transplantation and the presence of donor specific antibodies (DSA) is associated with an…
2021 American Transplant Congress
Effects of IL-2 and/ or Anti-IL6R Therapy on Long-term Cardiac Allograft Survival in Non-Human Primates (NHPs)
C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, J. A. Morrissette, D. Becerra, T. Costa, A. Dehnadi, I. M. Hanekamp, G. Benichou, J. C. Madsen
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA
*Purpose: Cardiac allograft tolerance in NHPs has been achieved by our group using a mixed chimerism model with allogeneic bone marrow transplant after non-myeloablative conditioning…
2021 American Transplant Congress
Association of Immune Cell Markers with Adverse Outcomes in the First 6 Months Post-pediatric Heart Transplantation
J. Chen¹, D. Salerno², H. Corbo¹, S. Shah³, A. Rothkopf⁴, I. D. Lytrivi⁴
¹Department of Pharmacy, Columbia University Irving Medical Center, New York, NY, ²Department of Pharmacy, Weill Cornell Medical Center, New York, NY, ³College of Pharmacy and Health Sciences, St. John's University, Queens, NY, ⁴Pediatric Cardiology, Columbia University Irving Medical Center, New York, NY
*Purpose: Immunosuppression titration post-orthotopic heart transplant (OHT) is limited to trough level monitoring and does not provide data pertaining to overall state of immunosuppression. Additional…
2021 American Transplant Congress
De Novo Donor Specific Antibodies After Heart Transplantation in Fontan Patients with Protein Losing Enteropathy
D. A. Magnetta¹, V. Hoch², D. Pinelli³, M. Monge⁴, E. Pahl¹, P. T. Thrush¹
¹Pediatric Cardiology, Lurie Children's Hospital, Chicago, IL, ²Northwestern School of Medicine, Chicago, IL, ³Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Pediatric Cardiothoracic Surgery, Lurie Children's Hospital, Chicago, IL
*Purpose: Protein Losing Enteropathy (PLE) complicates Fontan physiology and can be an indication for heart transplantation (HT). PLE is accompanied by immune dysregulation, potentially impacting…

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