ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Heart"

  • 2021 American Transplant Congress

    Predicted Heart Mass Difference as a Risk Factor for Severe Primary Graft Dysfunction in the Contemporary Era of Heart Transplantation: A Report from the International Consortium on Primary Graft Dysfunction

    F. Foroutan1, L. K. Truby2, Y. Moayedi1, J. Han3, J. Guzman4, M. Farrero4, E. Baughan5, M. Farr5, H. Zafar6, J. Felius6, J. van Zyl7, D. Law8, S. Chih8, P. Angleitner9, M. Sabatino10, A. DeVore2, R. J. Miller11, L. Potena10, A. Zuckermann9, K. K. Khush3, S. A. Hall6, H. J. Ross1

    1Ted Rogers Centre for Heart Research, Toronto, ON, Canada, 2Duke University School of Medicine, Durham, NC, 3Stanford University, Stanford, CA, 4Clinic Barcelona Hospital Universitari, Barcelona, Spain, 5Columbia University Medical Center, New York, NY, 6Baylor University Medical Center, Dallas, TX, 7Dallas University Medical Center, Dallas, TX, 8University of Ottawa Heart Institute, Ottawa, ON, Canada, 9Medical University of Vienna, Vienna, Austria, 10Bologna University Hospital, Bologna, Italy, 11University of Calgary, Calgary, AB, Canada

    *Purpose: Primary Graft Dysfunction (PGD) increases early mortality after heart transplant (HT). Predicted heart mass (PHM) difference may be a risk factor for PGD. Lack…
  • 2021 American Transplant Congress

    A Novel Mouse Model of Cardiac Allograft Vasculopathy

    H. Tsuda1, E. Reed2, W. Baldwin1, R. Fairchild1

    1Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, 2Pathology and Laboratory Medicine, University of California, Los Angeles, CA

    *Purpose: Cardiac allograft vasculopathy (CAV) is a major long-term complication of heart transplantation and the presence of donor specific antibodies (DSA) is associated with an…
  • 2021 American Transplant Congress

    Effects of IL-2 and/ or Anti-IL6R Therapy on Long-term Cardiac Allograft Survival in Non-Human Primates (NHPs)

    C. L. Miller, K. J. Ahrens, J. M. O, P. M. Patel, J. A. Morrissette, D. Becerra, T. Costa, A. Dehnadi, I. M. Hanekamp, G. Benichou, J. C. Madsen

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    *Purpose: Cardiac allograft tolerance in NHPs has been achieved by our group using a mixed chimerism model with allogeneic bone marrow transplant after non-myeloablative conditioning…
  • 2021 American Transplant Congress

    Association of Immune Cell Markers with Adverse Outcomes in the First 6 Months Post-pediatric Heart Transplantation

    J. Chen1, D. Salerno2, H. Corbo1, S. Shah3, A. Rothkopf4, I. D. Lytrivi4

    1Department of Pharmacy, Columbia University Irving Medical Center, New York, NY, 2Department of Pharmacy, Weill Cornell Medical Center, New York, NY, 3College of Pharmacy and Health Sciences, St. John's University, Queens, NY, 4Pediatric Cardiology, Columbia University Irving Medical Center, New York, NY

    *Purpose: Immunosuppression titration post-orthotopic heart transplant (OHT) is limited to trough level monitoring and does not provide data pertaining to overall state of immunosuppression. Additional…
  • 2021 American Transplant Congress

    De Novo Donor Specific Antibodies After Heart Transplantation in Fontan Patients with Protein Losing Enteropathy

    D. A. Magnetta1, V. Hoch2, D. Pinelli3, M. Monge4, E. Pahl1, P. T. Thrush1

    1Pediatric Cardiology, Lurie Children's Hospital, Chicago, IL, 2Northwestern School of Medicine, Chicago, IL, 3Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, 4Pediatric Cardiothoracic Surgery, Lurie Children's Hospital, Chicago, IL

    *Purpose: Protein Losing Enteropathy (PLE) complicates Fontan physiology and can be an indication for heart transplantation (HT). PLE is accompanied by immune dysregulation, potentially impacting…
  • 2021 American Transplant Congress

    Core Signature of Rejection-Specific Cytokines and Chemokines in Heart Biopsies After Transplantation

    L. M. Radomsky1, Y. Scheibner2, J. F. Kuehne1, J. Keil1, K. Beushausen1, K. Ludmilla2, A. Schick2, F. Ius2, G. Warnecke3, C. Bara2, C. S. Falk1

    1Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, 2Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany, 3Clinic for Cardiac Surgery, University of Heidelberg, Heidelberg, Germany

    *Purpose: Allograft rejection remains one of the limiting factors for survival after HTX. The aim of this project was to characterize the cytokine/chemokine network in…
  • 2021 American Transplant Congress

    Association Between Cumulative Antithymocyte Globulin Dosing and Adverse Outcomes in Pediatric Heart Transplant Recipients

    J. Chen1, D. Salerno1, H. Corbo1, S. Shah2, A. Rothkopf3, I. D. Lytrivi3

    1Department of Pharmacy, NewYork-Presbyterian Hospital, New York, NY, 2College of Pharmacy and Health Sciences, St. John's University, Queens, NY, 3Pediatric Cardiology, Columbia University Irving Medical Center, New York, NY

    *Purpose: Lymphocyte depletion via rabbit antithymocyte globulin (rATG) is the most frequently used induction immunosuppressive in pediatric orthotopic heart transplant (OHT). Although outcomes are often…
  • 2021 American Transplant Congress

    Impact of New Onset Diabetes After Transplantation on Heart Transplant Recipients

    W. Kang1, W. Keattiyoat2, M. Kim1, C. Bhardwaj2

    1Department of Internal Medicine, University of Illinois College of Medicine at Peoria, Peoria, IL, 2Department of Cardiology, University of Illinois College of Medicine at Peoria, Peoria, IL

    *Purpose: The purpose of this study is to investigate New Onset Diabetes After Transplantation (NODAT) incidence and its impact on post-transplant prognosis in adult heart…
  • 2021 American Transplant Congress

    The Gut Microbiome in Heart Transplantation: A Prospective Pilot Study

    M. Dela Cruz1, E. Littmann2, R. Nayak2, C. Lehmann2, R. Keskey3, T. Baker3, H. Lin2, A. Bennett1, G. Kim1, S. Pinney1, E. Pamer2, A. B. Nguyen1

    1Cardiology, University of Chicago, Chicago, IL, 2Medicine, University of Chicago, Chicago, IL, 3Surgery, University of Chicago, Chicago, IL

    *Purpose: The contribution of the intestinal microbiome to alloimmunity in heart transplantation (HT) is unknown. We examined the fecal microbiota of HT recipients at the…
  • 2021 American Transplant Congress

    Breakthrough Cytomegalovirus DNAemia in High vs Intermediate Risk Heart Transplant Recipients

    G. Huang1, O. E. Beaird1, M. Davis2, M. Carlson1, S. Chang1, P. Gaynor1, A. Fan2, M. Deng3, A. Multani1, A. Nsair3, J. Schaenman1

    1Infectious Diseases, UCLA, Los Angeles, CA, 2Pharmacy, UCLA, Los Angeles, CA, 3Cardiology, UCLA, Los Angeles, CA

    *Purpose: Cytomegalovirus (CMV) is one of the most common infections after transplantation and continues to cause significant morbidity and mortality despite prophylaxis and screening strategies.…
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