ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Heart"

  • 2016 American Transplant Congress

    Neonatal Tolerance to Blood Group A-Antigen in a Mouse Model of ABO-Incompatible Heart Transplantation (ABOi HTx).

    B. Motyka,1 B. Lamarche,1 K. Labonte,1 S. Wang,1 J. Pearcey,1 K. Tao,1 M. Mengel,1 B. Sis,1 P. Cowan,2 L. West.1

    1Alberta Transplant Institute/CNTRP, University of Alberta, Edmonton, Canada; 2Immunology Research Centre, St Vincent's Hospital, Melbourne, Australia.

    Purpose: ABOi HTx can be performed safely in infants due to lack of natural anti-A/B antibodies (Ab), in contrast to adults. Following ABOi HTx, B…
  • 2016 American Transplant Congress

    C5a Induces CSF1-Dependent Regulatory Macrophage (Mreg) Development Required for Murine Allograft Tolerance.

    I. Llaudo, P. Conde, J. Ochando, P. Heeger.

    Icahn School of Medicine at Mount Sinai, New York, NY.

    Anti-CD40L (MR1) induced heart transplant tolerance has been recently shown to be dependent on early post-transplant intragraft accumulation of CD11b+Ly6CLoLy6G- DC-SIGN expressing Mreg that develop…
  • 2016 American Transplant Congress

    Recapitulating Peripheral T Cell Development in Neonatal Mice to Induce Transplant Tolerance.

    R. Bascom, K. Tao, L. West.

    University of Alberta, Edmonton, Canada.

    Purpose: Neonatal mice are susceptible to tolerance induction with semi-allogeneic bone marrow and spleen cells (BMC/SC) while allogeneic BMC/SC cause acute lethal graft-versus-host disease (GVHD).…
  • 2016 American Transplant Congress

    Cold Storage Stabilization of Gap Junctions Reduces Post Transplant Ischemia Reperfusion Injury.

    R. Finnegan,1 P. Zhu,1 S. Stephenson,1 K. Patel,2 S. Nadig,1,2,3 C. Atkinson.1,2,3

    1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; 2Department of Surgery, Medical University of South Carolina, Charleston, SC; 3South Carolina Investigators in Transplantation, Medical University of South Carolina, Charleston, SC.

    Purpose: Organ procurement, cold storage and ischemia reperfusion injury (IRI) promote inflammation, which induces endothelial cell (EC) activation and dysfunction post transplantation. EC gap junctions…
  • 2016 American Transplant Congress

    Rapamycin Prolongs Cardiac Allograft Survival in a Mouse Model by Inducing Myeloid-Derived Suppressor Cells.

    T. Nakamura, K. Masuda, T. Matsuyama, H. Ushigome, N. Yoshimura.

    Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.

    Mammalian target of rapamycin (mTOR) inhibitors are the main immunosuppressive drugs for organ transplant recipients. Nevertheless, the mechanisms by which mTOR inhibitors induce immunosuppression is…
  • 2016 American Transplant Congress

    Thoracic Simulation Allocation Modeling (TSAM) of a 6-Tier Allocation Strategy.

    M. Colvin,1 M. Skeans,1 L. Robbins Callahan,2 L. Edwards,2 J. Zeglin,1 S. Silvestry,3 R. Davies,4 M. Farr,5 A. Israni,1 J. Rogers.6

    1SRTR, Minneapolis; 2UNOS, Richmond; 3Florida Hospital Transplant Inst, Orlando; 4Nemours/AI duPont Hosp for Children, Wilmington; 5Columbia Univ Medical Center, New York; 6Duke Univ, Durham.

    Heart allocation policy (OPTN policy 6) is in development. To stratify medical urgency, the Heart Subcommittee of the OPTN Thoracic Committee developed a 6-tier algorithm…
  • 2016 American Transplant Congress

    Medicaid Insurance Is Associated with Shorter Time to Transplant Listing After LVAD Implantation.

    W. Schultz, M. Yin, Y.-A. Ko, J. Vega, A. Morris.

    Emory University School of Medicine, Atlanta, GA.

    Introduction: Left-ventricular assist devices (LVAD) and total artificial hearts (TAH) are being increasingly utilized as a bridge to heart transplant (HT). Prior studies have demonstrated…
  • 2016 American Transplant Congress

    Pre-Transplant Coronary Artery Disease: An Underestimated Risk Factor for Post-Transplant Mortality?

    D. Khadzhynov, F. Halleck, L. Lehner, M. Duerr, A. Kleinsteuber, K. Budde, O. Staeck.

    Nephrology, Charite Universitaetsmedizin, Berlin, Germany.

    Background: Coronary artery disease is a frequent comorbidity among transplant candidates. Limited data exist on the long-term outcomes of kidney transplant recipients (KTR) with pre-existing…
  • 2016 American Transplant Congress

    Thoracic Simulated Allocation Modeling (TSAM) of Broader Sharing.

    M. Colvin,1 M. Skeans,1 L. Robbins Callahan,2 L. Edwards,2 J. Zeglin,1 S. Silvestry,3 R. Davies,4 M. Farr,5 A. Israni,1 J. Rogers.6

    1SRTR, Minneapolis, MN; 2UNOS, Richmond, VA; 3Florida Hospital Transplant Institute, Orlando, FL; 4Nemours/A.I. duPont Hospital for Children, Wilmington, DE; 5Columbia University Medical Center, New York, NY; 6Duke University, Durham, NC.

    Heart allocation policy (OPTN policy 6) is in development. The Heart Subcommittee of the OPTN Thoracic Committee developed a 6-tiered medical urgency algorithm, then investigated…
  • 2016 American Transplant Congress

    Cardiovascular Prognosis and Adverse Cardiac Events After Orthotopic Liver Transplantation.

    L. Potena, V. Manfredini, P. Prestinenzi, R. Alabrese, V. Bertuzzo, L. Borgese, M. Masetti, C. Morelli, F. Grigioni, A. Pinna.

    University of Bologna, Bologna, Italy.

    Cardiovascular (CV) disease is a major cause of morbidity and mortality among transplant candidate and recipients of noncardiac organs. Aiming to analyze the impact of…
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