2017 American Transplant Congress
HCC and Cardiac Cirrhosis After the Fontan Procedure in a Patient with Congenital Heart Disease and Situs Inversus.
Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX
Introduction. Hypoplastic left heart syndrome (HLHS) is a fatal congenital cardiac anomaly for which surgical palliation is needed, the Fontan procedure. HLHS accounts for <5%…2017 American Transplant Congress
Carotid Intima-Media Thickness and Myocardial Strain in Pediatric Kidney Transplant Recipients.
Children's National, Washington DC
A prospective controlled longitudinal study was conducted to investigate determinants of carotid intima-media thickness (CIMT) and myocardial strain in children after kidney transplant (Tx).Methods: 42…2017 American Transplant Congress
A Promising MyD88 Inhibitor TJ-M2010-2 Protects Heart from Myocardial Ischemia Reperfusion Injury.
BACKGROUND: The activation of innate immunity via myeloid differentiation factor 88 (MyD88) contributes to myocardial ischemia reperfusion injury (IRI). This study is to investigate the…2017 American Transplant Congress
Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.
Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…2017 American Transplant Congress
Mitochondrial Permeability Can Regulate Endothelial Cell Necroptosis and Promote Cardiac Allograft Rejection.
Background: Transplant injury is invariably associated with programmed cell death (PCD) resulting in organ rejection. Many forms of PCD have been described including apoptosis, pyroptosis,…2016 American Transplant Congress
Recapitulating Peripheral T Cell Development in Neonatal Mice to Induce Transplant Tolerance.
University of Alberta, Edmonton, Canada.
Purpose: Neonatal mice are susceptible to tolerance induction with semi-allogeneic bone marrow and spleen cells (BMC/SC) while allogeneic BMC/SC cause acute lethal graft-versus-host disease (GVHD).…2016 American Transplant Congress
Cold Storage Stabilization of Gap Junctions Reduces Post Transplant Ischemia Reperfusion Injury.
Purpose: Organ procurement, cold storage and ischemia reperfusion injury (IRI) promote inflammation, which induces endothelial cell (EC) activation and dysfunction post transplantation. EC gap junctions…2016 American Transplant Congress
Rapamycin Prolongs Cardiac Allograft Survival in a Mouse Model by Inducing Myeloid-Derived Suppressor Cells.
Mammalian target of rapamycin (mTOR) inhibitors are the main immunosuppressive drugs for organ transplant recipients. Nevertheless, the mechanisms by which mTOR inhibitors induce immunosuppression is…2016 American Transplant Congress
Thoracic Simulation Allocation Modeling (TSAM) of a 6-Tier Allocation Strategy.
Heart allocation policy (OPTN policy 6) is in development. To stratify medical urgency, the Heart Subcommittee of the OPTN Thoracic Committee developed a 6-tier algorithm…2016 American Transplant Congress
Medicaid Insurance Is Associated with Shorter Time to Transplant Listing After LVAD Implantation.
Emory University School of Medicine, Atlanta, GA.
Introduction: Left-ventricular assist devices (LVAD) and total artificial hearts (TAH) are being increasingly utilized as a bridge to heart transplant (HT). Prior studies have demonstrated…
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