ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Heart"

  • 2017 American Transplant Congress

    HCC and Cardiac Cirrhosis After the Fontan Procedure in a Patient with Congenital Heart Disease and Situs Inversus.

    P. Nguyen, N. Galvan, M. Kueht, C. O'Mahony, R. Cotton, A. Rana, J. Goss.

    Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX

    Introduction. Hypoplastic left heart syndrome (HLHS) is a fatal congenital cardiac anomaly for which surgical palliation is needed, the Fontan procedure. HLHS accounts for <5%…
  • 2017 American Transplant Congress

    Carotid Intima-Media Thickness and Myocardial Strain in Pediatric Kidney Transplant Recipients.

    K. Sgambat, S. Clauss, M. Lasota, A. Moudgil.

    Children's National, Washington DC

    A prospective controlled longitudinal study was conducted to investigate determinants of carotid intima-media thickness (CIMT) and myocardial strain in children after kidney transplant (Tx).Methods: 42…
  • 2017 American Transplant Congress

    A Promising MyD88 Inhibitor TJ-M2010-2 Protects Heart from Myocardial Ischemia Reperfusion Injury.

    Y. Miao, L. Xie, X. Zhang, Z.-C. Ding, M. Yang, Y. Yang, P. Zhou.

    Institute of Qrgan Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology; Key Labrory of Organ Transplantation, Wuhan, Hubei, China

    BACKGROUND: The activation of innate immunity via myeloid differentiation factor 88 (MyD88) contributes to myocardial ischemia reperfusion injury (IRI). This study is to investigate the…
  • 2017 American Transplant Congress

    Deleting LAG-3 Accelerates Cardiac Allograft Rejection and Augments T Cell Memory in Mice.

    J. Erfe,1,2 C. Yang,1 D. Ndishabandi,1 I. Rosales,1 R. White,1 P. Russell,1 R. Colvin,1 J. Madsen,1 A. Alessandrini.1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA; 2Yale School of Medicine, New Haven, CT

    Purpose: Lymphocyte Activation Gene-3 (LAG-3) expresses a transmembrane receptor on activated immune cells such as T cells, NK cells, and plasmacytoid dendritic cells. It is…
  • 2017 American Transplant Congress

    Mitochondrial Permeability Can Regulate Endothelial Cell Necroptosis and Promote Cardiac Allograft Rejection.

    I. Gan,1,2 J. Jiang,1 D. Lian,1 A. Jevnikar,1,3 Z.-X. Zhang.1,2

    1Matthew Mailing Centre for Translational Transplant Studies, Western University, London, ON, Canada; 2Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada; 3Department of Medicine, Western University, London, ON, Canada

    Background: Transplant injury is invariably associated with programmed cell death (PCD) resulting in organ rejection. Many forms of PCD have been described including apoptosis, pyroptosis,…
  • 2016 American Transplant Congress

    Recapitulating Peripheral T Cell Development in Neonatal Mice to Induce Transplant Tolerance.

    R. Bascom, K. Tao, L. West.

    University of Alberta, Edmonton, Canada.

    Purpose: Neonatal mice are susceptible to tolerance induction with semi-allogeneic bone marrow and spleen cells (BMC/SC) while allogeneic BMC/SC cause acute lethal graft-versus-host disease (GVHD).…
  • 2016 American Transplant Congress

    Cold Storage Stabilization of Gap Junctions Reduces Post Transplant Ischemia Reperfusion Injury.

    R. Finnegan,1 P. Zhu,1 S. Stephenson,1 K. Patel,2 S. Nadig,1,2,3 C. Atkinson.1,2,3

    1Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; 2Department of Surgery, Medical University of South Carolina, Charleston, SC; 3South Carolina Investigators in Transplantation, Medical University of South Carolina, Charleston, SC.

    Purpose: Organ procurement, cold storage and ischemia reperfusion injury (IRI) promote inflammation, which induces endothelial cell (EC) activation and dysfunction post transplantation. EC gap junctions…
  • 2016 American Transplant Congress

    Rapamycin Prolongs Cardiac Allograft Survival in a Mouse Model by Inducing Myeloid-Derived Suppressor Cells.

    T. Nakamura, K. Masuda, T. Matsuyama, H. Ushigome, N. Yoshimura.

    Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.

    Mammalian target of rapamycin (mTOR) inhibitors are the main immunosuppressive drugs for organ transplant recipients. Nevertheless, the mechanisms by which mTOR inhibitors induce immunosuppression is…
  • 2016 American Transplant Congress

    Thoracic Simulation Allocation Modeling (TSAM) of a 6-Tier Allocation Strategy.

    M. Colvin,1 M. Skeans,1 L. Robbins Callahan,2 L. Edwards,2 J. Zeglin,1 S. Silvestry,3 R. Davies,4 M. Farr,5 A. Israni,1 J. Rogers.6

    1SRTR, Minneapolis; 2UNOS, Richmond; 3Florida Hospital Transplant Inst, Orlando; 4Nemours/AI duPont Hosp for Children, Wilmington; 5Columbia Univ Medical Center, New York; 6Duke Univ, Durham.

    Heart allocation policy (OPTN policy 6) is in development. To stratify medical urgency, the Heart Subcommittee of the OPTN Thoracic Committee developed a 6-tier algorithm…
  • 2016 American Transplant Congress

    Medicaid Insurance Is Associated with Shorter Time to Transplant Listing After LVAD Implantation.

    W. Schultz, M. Yin, Y.-A. Ko, J. Vega, A. Morris.

    Emory University School of Medicine, Atlanta, GA.

    Introduction: Left-ventricular assist devices (LVAD) and total artificial hearts (TAH) are being increasingly utilized as a bridge to heart transplant (HT). Prior studies have demonstrated…
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