Articles tagged "Heart"

2018 American Transplant Congress
Mitochondrial Quality Control through PGC-1α in Syngenic Mouse Heart Transplant
A. Cherry,¹ K. Porter,¹ H. Suliman,¹ J. Wang,² M. Mulvihill,² A. Kirk.²
¹Anesthesiology, Duke University, Durham, NC; ²Surgery, Duke University, Durham, NC.
Intro: Impaired mitochondrial function plays a role in graft dysfunction after transplant, and recovery is facilitated by mitochondrial quality control (MQC). Two key elements of…
2018 American Transplant Congress
Increasing Use of Exceptions after Changes to Pediatric Heart Allocation
A. Robinson,¹ W. Mahle,² R. Davies.³
¹United Network for Organ Sharing, Richmond, VA; ²Children's Healthcare of Atlanta, Atlanta, GA; ³Children's Medical Center of Dallas, Dallas, TX.
Purpose: Pediatric heart allocation in the United States was changed in 2016. The primary goal was to better align candidate status with waitlist mortality. Whether…
2018 American Transplant Congress
T-Cell Expression of C5a Receptor 2 Augments Murine Regulatory T Cell Generation and Regulatory-T-Cell-Dependent Cardiac Allograft Survival
N. Chun,¹ D. Verghese,¹ M. Demir,¹ M. Fribourg,³ I. Llaudo,¹ E. Medof,⁴ P. Heeger.¹
¹Div of Nephrology, Dept of Medicine, Translational Transplant Research Center, Icahn School of Medicine at Mount Sinai, NY, NY; ²Dept of Neurology, Icahn School of Medicine at Mount Sinai, NY, NY; ³Dept of Pathology, Case Western Reserve Univ, Cleveland, OH.
C5aR2 (C5L2/gp77) is a transmembrane receptor that binds C5a but lacks motifs needed to induce G-protein coupled signal transduction. C5aR2 modulates various inflammatory diseases in…
2018 American Transplant Congress
Upregulated IL-33 in Heart Transplants Modulates Local Myeloid Populations to Protect against Chronic Allograft Rejection
Z. Zhang,¹ Q. Liu,¹ G. Hussey,² J. Dziki,² L. Mathews,¹ H. Dai,¹ G. Dwyer,^1,3 A. Lucas,¹ M. Oberbarnscheidt,¹ S. Badylak,² H. Turnquist.^1,3
¹University of Pittsburgh, Starzl Transplant Institute, Pittsburgh, PA; ²University of Pittsburgh, McGowan Institute for Regenerative Medicine, Pittsburgh, PA; ³Immunology, University of Pittsburgh, Pittsburgh, PA.
Purpose: Interleukin-33 (IL-33) is an “alarmin”, or a self-derived molecule that triggers pleotropic immune responses after release from damaged tissue. Yet, how IL-33 shapes alloresponses…
2018 American Transplant Congress
IL-21 Regulates Creation of Tertiary Lymphoid Organs in Chronic Allograft Rejection
J. Breidenbach, C. Baum, P. Schroder, S. Stepkowski.
Medical Microbiology and Immunology, University of Toledo College of Medicine and Life Science, Toledo, OH.
Background: IL-21 is a cytokine expressed almost exclusively by cells of the adaptive immune system, making it an attractive target for reducing chronic allograft rejection…
2018 American Transplant Congress
Role of B Cell Intrinsic NLRP3 in the Development of Chronic Rejection
J. Nie,¹ B. Ramaswami,² X. Guo,³ R. Hoffman,² G. Chalasani.³
¹Thoracic Surgery, Huazhong University of Science and Technology, Wuhan, Hubei, China; ²Surgery, Starzl Transplantation Institute, Pittsburgh, PA; ³Medicine, University of Pittsburgh, Pittsburgh, PA.
Endogenous DAMPs elicited during transplantation are recognized via TLR-MyD88 and NLRP3-inflammosome pathways that are expressed in APCs including B cells. Here, we asked whether B…
2018 American Transplant Congress
Functional Assessment of Kidney Transplant Candidates with the 6 Minute Walk Test and Hand Grip Strength
S. Anand,¹ S. Gilligan,² D. Morris,¹ T. Srinivas.
¹Transplant Nephrology, Intermountain Healthcare, Murray; ²University of Utah, Murray, UT.
Background: The 6 minute walk test distance (6MWT) and Isometric hand grand grip strength (HGS) have been studied in various settings as objective measures of…
2018 American Transplant Congress
Measures of Physical Frailty, Cardiac Function and Cardiac Biomarkers among Kidney Transplant Candidates
S. Gilligan,¹ S. Anand,² D. Morris,² M. Minder,¹ T. Srinivas.²
¹Intermountain Medical Center, Murray, UT; ²University of Utah, Salt Lake City, UT.
Background: Elevated troponin T at transplant evaluation has been reported to confer risk of cardiovascular mortality among renal transplants. We use troponin T along with…
2018 American Transplant Congress
A Single Center Transition of Care Model from Pediatric Heart Recipients to Adult Services Ongoing Study Model
S. Adams, M. Wigger.
Heart Transplant, Vanderbilt Medical Center, Nashville, TN.
This is an ongoing look at designing a pediatric to adult transition model and lessons learned over time. It has been shown that the first…
2018 American Transplant Congress
Mitochondrial Membrane Permeability Plays a Critical Role for Endothelial Cell Necroptosis and Cardiac Allograft Rejection
I. Gan, J. Jiang, D. Lian, X. Huang, W. Liu, A. Haig, A. Jevnikar, Z. Zhang.
Matthew Mailing Centre for Translational Transplant Studies, University of Western Ontario, London, ON, Canada; Multi Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; Pathology and Laboratory Medicine, University of Western Ontario, London, ON, Canada; Medicine, University of Western Ontario, London, ON, Canada.
Background: Transplant injury is invariably associated with programmed cell death resulting in delayed graft function and organ rejection. We were the first to describe receptor-interacting…