Articles tagged "Heart"

2018 American Transplant Congress
Functional Assessment of Kidney Transplant Candidates with the 6 Minute Walk Test and Hand Grip Strength
S. Anand,¹ S. Gilligan,² D. Morris,¹ T. Srinivas.
¹Transplant Nephrology, Intermountain Healthcare, Murray; ²University of Utah, Murray, UT.
Background: The 6 minute walk test distance (6MWT) and Isometric hand grand grip strength (HGS) have been studied in various settings as objective measures of…
2018 American Transplant Congress
Measures of Physical Frailty, Cardiac Function and Cardiac Biomarkers among Kidney Transplant Candidates
S. Gilligan,¹ S. Anand,² D. Morris,² M. Minder,¹ T. Srinivas.²
¹Intermountain Medical Center, Murray, UT; ²University of Utah, Salt Lake City, UT.
Background: Elevated troponin T at transplant evaluation has been reported to confer risk of cardiovascular mortality among renal transplants. We use troponin T along with…
2018 American Transplant Congress
A Single Center Transition of Care Model from Pediatric Heart Recipients to Adult Services Ongoing Study Model
S. Adams, M. Wigger.
Heart Transplant, Vanderbilt Medical Center, Nashville, TN.
This is an ongoing look at designing a pediatric to adult transition model and lessons learned over time. It has been shown that the first…
2018 American Transplant Congress
Mitochondrial Membrane Permeability Plays a Critical Role for Endothelial Cell Necroptosis and Cardiac Allograft Rejection
I. Gan, J. Jiang, D. Lian, X. Huang, W. Liu, A. Haig, A. Jevnikar, Z. Zhang.
Matthew Mailing Centre for Translational Transplant Studies, University of Western Ontario, London, ON, Canada; Multi Organ Transplant Program, London Health Sciences Centre, London, ON, Canada; Pathology and Laboratory Medicine, University of Western Ontario, London, ON, Canada; Medicine, University of Western Ontario, London, ON, Canada.
Background: Transplant injury is invariably associated with programmed cell death resulting in delayed graft function and organ rejection. We were the first to describe receptor-interacting…
2018 American Transplant Congress
ABO Tolerance after Treatment of Infant or Adult Mice with MHC-Matched A-Expressing Blood Cells
B. Motyka,¹ J. Fersovich,¹ B. Lamarche,¹ M. Sosniuk,¹ I. Adam,¹ J. Pearcey,¹ K. Tao,¹ C. Cairo,² P. Cowan,³ L. West.¹
¹Dept Pediatrics, Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada; ²Dept Chemistry, University of Alberta, Edmonton, Canada; ³St Vincent's Hospital, Melbourne, Australia.
Purpose: ABO-incompatible heart transplantation (ABOi HTx) is safe during infancy and allows increased donor access. Post-ABOi HTx B cell tolerance develops to donor blood group…
2018 American Transplant Congress
Geographic Variation in the Treatment of Adult Heart Transplant Candidates in the US
W. Parker,¹ M. Churperk,¹ D. Hedeker,¹ E. Huang,¹ E. Garrity,¹ M. Siegler,¹ A. Anderson.²
¹University of Chicago, Chicago, IL; ²Northwestern University, Chicago, IL.
The current priority ranking system for US heart transplant candidates is based on treatment intensity which may encourage the overtreatment of relatively stable candidates. We…
2018 American Transplant Congress
Myeloid-Derived Suppressor Cells Suppress with Enhanced Donor Specificity in Donor ECDI-SP Treated Recipients
L. Zhang, J. Wang, Z. Zhang, X. Luo.
Northwestern University Feinberg School of Medicine, Chicago.
Introduction: Published data in cancer models have shown that myeloid-derived suppressor cells (MDSCs) can induce antigen-specific CD8 T cell tolerance and promote tumor escape (Nagaraj…
2018 American Transplant Congress
Heart Transplantation in Patients with Complex Congenital Heart Disease
M. Kittleson, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa, R. Garg, E. Zahn.
Cedars Sinai Medical Center, Los Angeles.
Purpose: As medical and surgical management of complex congenital heart disease (CCHD) improves, patients may survive into adulthood to suffer from end-stage heart failure and…
2018 American Transplant Congress
Human Thrombomodulin Expression on Genetically Modified Donor Pigs is Required to Maintain the Anti-Coagulation Profile
A. Singh, L. DiChiacchio, J. Chan, P. Corcoran, B. Lewis, M. Thomas, D. Ayares, K. Horvath, M. Mohiuddin.
CSRP/NHLBI and DVR/ORS, NIH, Bethesda, MD; Revivicor Inc., Blacksburg, VA; Dept of Surgery, University of Maryland, Baltimore, MD.
Introduction: Coagulation dysregulation is major limitation for xenotransplantation but it is resolved to some extent by making genetically engineered (GE) pigs, which express complement inhibitors…
2018 American Transplant Congress
Differences in Pediatric and Adult Lost to Follow-Up Events for Heart, Kidney, and Liver Recipients
A. Robinson,¹ G. Mazariegos,² S. Bartosh,³ W. Mahle.⁴
¹United Network for Organ Sharing, Richmond, VA; ²Children's Hospital of Pittsburgh, Pittsburgh, PA; ³University of Wisconsin Hospital and Clinics, Madison, WI; ⁴Children's Healthcare of Atlanta, Atlanta, GA.
Background: Long-term follow-up data are necessary for accurate survival estimation. While the majority of heart (HR), kidney (KI), and liver (LI) transplant recipients (TxR) are…