Articles tagged "Heart transplant patients"

2016 American Transplant Congress
Delaying the Induction of Mixed Chimerism Until Two Months After NHP Heart and Kidney Cotransplantation Results in Long Term Survival.
K. Huh,¹ M. Tonsho,¹ P. Spencer,¹ J. Paster,¹ X. Wu,¹ I. Hanekamp,¹ T. Kawai,^1,3 R. Smith,² A. Cosimi,¹ A. Dehnadi,¹ G. Benichou,¹ R. Colvin,^1,2 J. Madsen.^1,4
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Boston, MA; ³Department of Surgery, Massachusetts General Hospital, Boston, MA; ⁴Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA.
Background. We have previously achieved delayed tolerance in cynomologous recipients cotransplanted with heart and kidney allografts by treating recipients with standard triple drug immunosuppression for…
2016 American Transplant Congress
Posterior Reversible Encephalopathy Syndrome After Pediatric Heart Transplantation: Increased Risk for Children with Preexisting Glenn/Fontan Physiology.
M. Kemna,¹ B. Eilers,² E. Albers,¹ Y. Law.¹
¹Pediatric Cardiology, Seattle Children's Hospital, Seattle, WA; ²School of Medicine, University of Washington, Seattle, WA.
Study aim:Identification of risk factors for posterior reversible encephalopathy syndrome (PRES) after organ transplant can improve early detection and avoid permanent neurologic injury. High calcineurin-inhibitor…
2016 American Transplant Congress
Renal Outcomes of Pediatric Kidney Transplant Recipients Following a Previous Solid Organ Transplantation.
G. Hamdani,¹ B. Zhang,² J. Goebel,³ E. Nehus.¹
¹Division of Nephrology & Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ²Center for Epidemiology & Biostatistics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH; ³Nephrology, Children's Hospital Colorado, Aurora, CO.
Purpose: We aimed to study the renal outcomes of pediatric kidney transplant recipients following a previous non-renal solid organ transplantation (SOT).Methods: A retrospective analysis of…
2016 American Transplant Congress
Elucidating Clinical Factors Implicated in Primary Graft Dysfunction After Heart Transplantation.
R. Quintana-Quezada, I. Rajapreyar, Y. Yeh, S. Choi, I. Gregoric, P. Loyalka, B. Kar.
Advanced Heart Failure, University of Texas Medical School at Houston, Houston, TX.
Primary graft dysfunction (PGD) is a frequent complication after heart transplantation (HT) and remains among the leading causes of mortality in these patients. We aim…
2016 American Transplant Congress
Natural Killer CD16/FcR Profiles May Associate with Enhanced Humoral Responsiveness in Heart Transplant Recipients with Cardiac Allograft Vasculopathy.
P. Paul,^1,2 C. Picard,^3,4 E. Sampol,⁵ L. Lyonnet,¹ J. Di Cristofaro,^3,4 G. Lano,^6, B. Dussol,^6, F. Collart,⁷ F. Sabatier,^1,2 F. Dignat George,^1,2 A. Mouly Bandini.⁷
¹Hematology, Assistance Publique-Hopitaux Marseille (AP-HM), Marseille, France; ²UMR-1076, Aix Marseille Université (AMU), INSERM, Marseille, France; ³Établissement Français du Sang, Marseille, France; ⁴UMR7268, AMU, CNRS, Marseille, France; ⁵Pharmacokinetics, AP-HM, Marseille, France; ⁶Center for Clinical Investigation, AP-HM, Marseille, France; ⁷Cardiac Surgery, AP-HM, Marseille, France.
Natural Killer cells (NK) are immune effectors of antibody-dependent cellular cytotoxicity (ADCC). Their role in mediating adverse effects of Donor-specific anti-HLA antibodies (DSA) towards cardiac…
2016 American Transplant Congress
Morbidity and Mortality of Early Post-Operative Acute Kidney Injury in Cardiothoracic Transplant Recipients.
J. Casale, A. Logan, C. Doligalski.
Tampa General Hospital, Tampa, FL.
Purpose: Early acute kidney injury (AKI) in cardiothoracic transplant recipients (CTTR) has not been well described; renal injury defined by the RIFLE criteria has been…
2016 American Transplant Congress
A New Diagnostic Score for Microvascular Inflammation in Antibody-Mediated Rejection in Heart Transplantation.
M. Racapé,¹ A. Loupy,² R. Guillemain,¹ A. François,³ P. Rouvier,⁴ C. Toquet,⁵ X. Jouven,¹ J. Venner,⁶ L. Hidalgo,⁶ J. Reeve,⁶ P. Bruneval,¹ J. Duong Van Huyen,² P. Halloran.²
¹European Georges Pompidou Hospital, Paris, France; ²Necker Hospital, Paris, France; ³Rouen University Hospital, Rouen, France; ⁴La Pitié Salpêtrière Hospital, Paris, France; ⁵Laennec Hospital, Nantes, France; ⁶University of Alberta, Edmonton, Canada.
BackgroundThe ISHLT working formulation defines Intravascular Activated Mononuclear Cells (IAMC) as one of the histopathologic features of antibody-mediated rejection (ABMR) in heart transplantation. However, no…
2015 American Transplant Congress
Clinically Relevant Wound Events With Everolimus-Based Immunosuppressive Regimen: Post-Hoc Analysis from a Randomized Heart Transplant Study
A. Zuckermann,¹ M. Rinaldi,¹ N. Yonan,¹ S.-S. Wang,¹ G. Dong,² P. Lopez.²
¹For the A2309 Study Group, Vienna, Austria; ²Novartis, Basel, Switzerland.
Purpose: In the A2310 (NCT00300274) heart transplant (HTx) study with everolimus (EVR) vs mycophenolate mofetil (MMF), information on a broad spectrum of potential wound healing…
2015 American Transplant Congress
Prevalence and Outcomes of Heart Transplantation in Children With Intellectual Disability
A. Wightman,¹ H. Bartlett,¹ Q. Zhao,² J. Smith.³
¹Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI; ²Biostatistics, University of Wisconsin School of Medicine and Public Health, Madison, WI; ³Pediatrics, University of Washington School of Medicine, Seattle, WA.
Background:Heart transplantation in children with intellectual disability (ID) is a controversial issue. Previous research on this population has been limited to small case reports.Objective:To describe…
2015 American Transplant Congress
Late Rejection in Pediatric Heart Transplantation: The Importance of Medical Adherence
A. Letica, W. Zuckerman, L. Addonizio, J. McAllister, T. Lee, M. Richmond.
Division of Pediatric Cardiology, Columbia University, New York, NY.
While the incidence of early rejection (<1 yr post-transplant) after pediatric heart transplant (HT) has decreased, late rejection (> 1 yr post-transplant) remains a constant…