2016 American Transplant Congress
Donor-Specific Antibody Is a Major Independent Predictor of Accelerated Heart Allograft Vasculopathy (CAV).
Introduction The role of circulating DSA in addition to traditional cardiovascular risk factors, in the development of accelerated CAV have not been demonstrated. We investigated…2016 American Transplant Congress
Anti-HLA Antibody Composition and Outcomes in Pediatric Heart Transplant Recipients with a Positive Cross-Match.
Purpose: Utilization of positive (+) cross-match (XM) hearts is tempting when shortages of pediatric donor hearts exist, especially for patients with high pre-transplant panel reactive…2016 American Transplant Congress
The Quilty Effect in Pediatric Heart Transplant Recipients.
Purpose: The Quilty effect is defined as the presence of a nodular endocardial infiltrate of lymphocytes in an endomyocardial biopsy (EMB), and has been described…2016 American Transplant Congress
Predicting Emergence of Anti-HLA Class I and II Antibodies by Time Dependent Phenomapping in Heart Transplant Patients.
Cardiology, University of California-Los Angeles, Los Angeles, CA.
Purpose: The presence of circulating HLA antibodies which is termed allosensitization among heart transplant (HTx) candidates are associated with poorer posttransplant outcomes including increased morbidity…2016 American Transplant Congress
Solid Phase Assay Demonstrates High Rates of Allosensitization in Pediatric Heart Recipients.
Allosensitization is a risk factor for rejection, vasculopathy and graft loss. CTOTC-04 is a prospective study assessing the impact of sensitization on a composite of…2016 American Transplant Congress
Impact of Donor Specific Antibodies on Cardiac Allograft Vasculopathy.
Purpose: Cardiac allograft vasculopathy (CAV) is a significant complication after cardiac transplantation (CTX). The presence of donor specific antibodies (DSA) has been associated with an…2016 American Transplant Congress
A Risk Quantification Score for Heart Transplants: A Heart Donor Risk Index.
Background: To better risk stratify heart transplants, we developed a continuous heart donor risk index (HDRI) based on heart donors to quantify heart allograft failure.Methods:…2016 American Transplant Congress
Relationship Between Changes in Brain Natriuretic Peptide Levels and Cardiac Allograft Rejection Early After Heart Transplantation.
1University of Colorado, Aurora, CO; 2Vanderbilt University, Nashville, TN.
Endomyocardial biopsies (EMBs) are routinely used to detect cardiac allograft rejection after heart transplantation (HTx), but they are invasive and costly. Serial changes in brain…2016 American Transplant Congress
Dilution of Patient Sera Improves MFI Correlation with Complement Fixation in Solid Phase Assay Assessment.
Background: Median Fluorescent Intensity (MFI) by solid phase assays (SPA) has been used to determine risk of donor-recipient reaction prior to transplant. Inconsistency of this…2016 American Transplant Congress
Gene Expression Profiling Score and the Risk of Infection in Heart Transplant Recipients.
Purpose: This study assessed the association of gene expression profiling (GEP, AlloMap®) score with infections in heart transplant recipients (HTR). Although a GEP score below…
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