Articles tagged "Heart transplant patients"

2017 American Transplant Congress
Timing, Frequency, and Precipitating Factors of Early Readmission After Heart Transplant.
J. Van Liew, L. Potter, N. Uriel, L. Lourenco.
University of Chicago Medicine, Chicago, IL
Purpose: Early hospital readmission after organ transplantation, defined as readmission within 30 days of discharge, has been found to be associated with increased morbidity and…
2017 American Transplant Congress
Is Thymic Function Determining Rejection Onset in Heart Transplantation?
A. Sannier,^1,2 R. Dorent,^1,3 M. Le Borgne,¹ N. Stroumza,¹ J. Senemaud,¹ L. Louedec,¹ F. Andreata,¹ A. Gaston,¹ C. Deschildre,¹ P. Nataf,^1,3 A. Couvelard,² G. Caligiuri,¹ A. Nicoletti.¹
¹Inserm U1148, Diderot University, Paris, France; ²Pathology Department, Bichat Hospital, Paris, France; ³Cardiac Surgery Department, Bichat Hospital, Paris, France
The thymus is the primary site of T cell development, involuting into fatty tissue in adults. Thymic function persists in the adulthood and may be…
2017 American Transplant Congress
CD16+ Monocytes and Skewed Macrophage Polarization Towards M2 Type Hallmark Heart Transplant Acute Cellular Rejection.
T. van den Bosch,¹ K. Caliskan,² M. Kraaij,¹ A. Constantinescu,² O. Manintveld,² P. Leenen,³ J. von der Thüsen,⁴ M. Clahsen-van Groningen,⁴ C. Baan,¹ A. Rowshani.¹
¹Internal Medicine and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands; ²Cardiology, Erasmus University Medical Center, Rotterdam, Netherlands; ³Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; ⁴Pathology, Erasmus University Medical Center, Rotterdam, Netherlands
Purpose: During acute heart transplant rejection, infiltration of lymphocytes and monocytes is followed by endothelial injury and eventually myocardial fibrosis. To date, no information is…
2017 American Transplant Congress
CD4 T Cells and Co-Engagement with Foreign Protein Are Required in Antibody Response to Non-Self Blood Group A-Antigen.
I. Adam, B. Motyka, L. West.
Micro & Immunology, ATI, CNTRP, University of Alberta, Edmonton, AB, Canada; Pediatrics, ATI, CNTRP, University of Alberta, Edmonton, AB, Canada; Pediatrics, Surgerey, and Immunology, ATI, CNTRP, University of Alberta, Edmonton, AB, Canada
Background: ABO-incompatible heart transplantation (ABOi HTx) is safe during infancy and allows increased donor access. B-cell tolerance develops to donor A/B-antigen(s) (Ag) after ABOi HTx…
2017 American Transplant Congress
Two Months Delayed Induction of Mixed Chimerism After Heart and Kidney Cotransplantation in Nonhuman Primates.
K. Huh,¹ W. Sommer,¹ K. Robinson,¹ X. Wu,¹ J. Paster,¹ I. Hanekamp,¹ A. Dehnadi,¹ T. Kawai,^1,2 R. Smith,³ R. Colvin,^1,3 G. Benichou,¹ J. Madsen.^1,4
¹Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital, Boston, MA; ²Department of Surgery, Massachusetts General Hospital, Boston, MA; ³Department of Pathology, Massachusetts General Hospital, Boston, MA; ⁴Division of Cardiac Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA
Background We have previously achieved transplant tolerance in cynomolgus recipients cotransplanted with heart and kidney by treating recipients with standard triple drug immunosuppression for 4…
2017 American Transplant Congress
Optimal Induction Therapy for Kidney Transplantation in Previous Heart Transplant Recipients: Analysis of OPTN/UNOS Registry.
M. Sampaio, S. Hussain, B. Chopra, K. Sureshkumar.
Nephrology, Internal Medicine, Allegheny General Hospital, Pittsburgh, PA
It is unclear as to which induction agent is optimal for kidney transplant (KT) in prior heart transplant (HT) recipients who are already immunocompromised from…
2017 American Transplant Congress
Identification of Promising Targets for Tolerance Induction Following Heart Transplantation.
K. Klaeske, M.-T. Dieterlen, J. Fischer, J. Hahn, K. Jawad, J. Garbade, F. Mohr, S. Lehmann.
Clinic for Cardiac Surgery, Heart Center Leipzig, Leipzig, Germany
Introduction: Tolerance-inducing cell subsets which can support the organ acceptance following heart transplantation (HTx) can be found among dendritic cells (DCs) and regulatory T cells…
2017 American Transplant Congress
Photopheresis for Recalcitrant Rejection After Heart Transplantation: Worthwhile?
J. Patel, M. Kittleson, X. Zhang, E. Klapper, T. Aintablian, K. Murayama, L. Czer, D. Geft, D. Chang, J. Kobashigawa.
Cedars-Sinai Heart Institute, Los Angeles
Background: Rejection is leading cause of mortality after heart transplantation (HTx). While the rates of rejection have declined over the past few decades from improvement…
2017 American Transplant Congress
Refinement of an Old Faithful: A Standardized Flow Cytometry Approach to Measure Donor-Recipient Alloreactivity (a Pilot Study).
A. Halpin,¹ M. Sosniuk,¹ S. Urschel,¹ P. Campbell,² I. Larsen,¹ L. West.¹
¹Pediatrics, Alberta Transplant Institute, Canadian National Transplant Reseach Program, University of Alberta, Edmonton, Canada; ²Lab Medicine and Pathology, University of Alberta, Edmonton, Canada
Purpose: Donor-specific antibody (DSA) and antibody (Ab)-mediated rejection are challenges in long-term outcomes and limit re-transplantation. Sensitizing events such as homografts in surgical procedures, assist…
2017 American Transplant Congress
Improved Creatinine Immediately Post-LVAD Predicts Lower AKI Risk After Heart Transplant.
A. Nanavati,¹ Y. He,³ N. Moazami,² S. Demirjian,¹ B. Stephany.¹
¹Nephrology, Cleveland Clinic, Cleveland, OH; ²Heart and Vascular Institute,Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, OH; ³University of Rochester, Rochester, NY
Background-Left ventricular assist device(LVAD) placement often improves renal function in patients with advanced heart failure. In those bridged to transplant with LVAD support it is…