2020 American Transplant Congress
ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Mercuric Chloride-Induced Renal Dysfunction and Mortality in Rats
Angion Biomedica, Uniondale, NY
*Purpose: ANG-3777 is a small-molecule mimetic of hepatocyte growth factor (HGF). In vitro models have shown ANG-3777 to have protective effects in renal cell lines,…2020 American Transplant Congress
Regulatory T Cell-Derived Amphiregulin Activates Fibroblasts to Promote Chronic Rejection after Heart Transplantation
*Purpose: Chronic rejection (CR) after organ transplantation (Tx) manifests as function-limiting allograft fibrosis and vasculopathy. Current immunosuppressants fail to prevent CR and insights into the…2020 American Transplant Congress
The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor C-MET Signaling
Angion Biomedica, Uniondale, NY
*Purpose: Hepatocyte growth factor (HGF) regulates cell growth, development and tissue repair. HGF activity is mediated by the c-MET signaling pathway. The biological effects of…2020 American Transplant Congress
Hepatocyte Growth Factor (HGF) Prevents the Apoptotic and Anti-Angiogenic Effect of Hypercholesterolemia on Hepatocytes in Liver Allografts
*Purpose: Background: Hypercholesterolemia (HC) impairs angiogenesis and induces apoptosis in livers. This hyperlipidemic impairment of angiogenesis reported associated with reduced bFGF. HGF stimulates proliferation, angiogenesis,…2020 American Transplant Congress
Bone Marrow Mesenchymal Stem Cells Improve Rat Islet Angiogenesis by Upregulating of ISL1 and VEGF-A
*Purpose: Islet transplantation is an important therapy to cure diabetes, but poor angiogenesis in the early stage of islet transplantation is one of the main…2020 American Transplant Congress
Multifactorial Effect of Hepatocyte Growth Factor (HGF) on the Microscopic Regeneration of Liver Allograft in Recipients Who Underwent Transplantation from Living Donors
*Purpose: Although partial liver allografts from living donors have near-complete regeneration of their liver volumes within weeks after transplantation, the microscopic range of regeneration is…2020 American Transplant Congress
ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Post-Transplant Renal Dysfunction in Rats
Angion Biomedica, Uniondale, NY
*Purpose: ANG-3777, a small-molecule mimetic of hepatocyte growth factor (HGF), has the potential to exert antifibrotic and nephroprotective effects. A rat model of renal transplantation…2020 American Transplant Congress
ANG-3777 Treatment Attenuates Ischemia-Reperfusion-Induced Renal Injury in Rat and Dog Models
1Angion Biomedica, Uniondale, NY, 2Virginia Commonwealth University, Richmond, VA
*Purpose: The effect of ANG-3777, a small-molecule mimetic of hepatocyte growth factor, was evaluated on reducing ischemia-reperfusion-induced renal injury and mortality in rats and dogs…2020 American Transplant Congress
In Vivo Phosphorylation of C-MET by ANG-3777, A Hepatocyte Growth Factor Mimetic
Angion Biomedica, Uniondale, NY
*Purpose: : The biological effects of hepatocyte growth factor/scatter factor (HGF) and its mimetics are mediated by a signal cascade initiated by binding of HGF…2020 American Transplant Congress
Stem Cell and Novel Neurotrophic Factors to Promote Functional Outcomes in Limb Transplantation
Clinical Investigation, Madigan Army Medical Center, Tacoma, WA
*Purpose: Recently, transplantation of hand and face has become a new clinical specialty. The objective of this study was to determine whether adult Mesenchymal Stem…
American Transplant Congress abstracts