ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Growth factors"

  • 2022 American Transplant Congress

    A Sustained Injury Response by Regulatory T Cells (Treg) Contributes to Fibrosis to Promote Chronic Rejection After Heart Transplantation

    J. Bou Saba1, L. Fan1, X. Zhang1, T. Li1, L. R. Mathews1, G. Dwyer2, E. Colon2, M. J. Calderon3, K. E. Helfrich3, M. A. Ross3, S. C. Watkins3, H. Turnquist1

    1Surgery, University of Pittsburgh, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, 2Immunology, University of Pittsburgh, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, 3Cell Biology, University of Pittsburgh, Center for Biologic Imaging, Pittsburgh, PA

    *Purpose: Chronic rejection (CR) results from the development of immunosuppressant-resistant allograft vasculopathy and fibrosis and remains a leading cause of recipient death one-year post-heart transplant…
  • 2021 American Transplant Congress

    Growth Differentiation Factor 15 Predictor Value is Superior to Troponin I in the Evaluation of Kidney Transplant Candidates

    M. de Cos Gomez1, M. Garcia Unzueta2, A. Benito Hernandez1, J. Mazon Ruiz1, M. Perez Arnedo1, A. Aguilera Fernandez1, R. Valero San Cecilio1, J. Ruiz San Millan1, E. Rodrigo Calabia1

    1Nephrology, Marques de Valdecilla University Hospital - IDIVAL, Santander, Spain, 2Clinical Analysis, Marques de Valdecilla University Hospital - IDIVAL, Santander, Spain

    *Purpose: Pretransplant cardiac troponin I (cTNI) has demonstrated its predictor value of survival after kidney transplant in previous studies. Growth differentiation factor 15 (GDF-15) is…
  • 2021 American Transplant Congress

    Liver Kinase B1 Knockdown Induces Platelet-Derived Growth Factor Receptor B Expression in Human Airway Epithelial Cells: A Potential Mechanism for Development of Fibrosis Leading to Chronic Lung Allograft Dysfunction

    M. Rahman, J. Lee, R. Ravichandran, T. Fleming, M. Smith, R. Bremner, T. Mohanakumar

    St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: The platelet-derived growth factor and its receptor (PDGFRb) signaling pathway can be activated by epithelial mesenchymal transition which facilitates fibrosis. It is not known…
  • 2020 American Transplant Congress

    ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Post-Transplant Renal Dysfunction in Rats

    P. Narayan, I. D. Goldberg

    Angion Biomedica, Uniondale, NY

    *Purpose: ANG-3777, a small-molecule mimetic of hepatocyte growth factor (HGF), has the potential to exert antifibrotic and nephroprotective effects. A rat model of renal transplantation…
  • 2020 American Transplant Congress

    ANG-3777 Treatment Attenuates Ischemia-Reperfusion-Induced Renal Injury in Rat and Dog Models

    P. Narayan1, M. Mangino2, I. D. Goldberg1

    1Angion Biomedica, Uniondale, NY, 2Virginia Commonwealth University, Richmond, VA

    *Purpose: The effect of ANG-3777, a small-molecule mimetic of hepatocyte growth factor, was evaluated on reducing ischemia-reperfusion-induced renal injury and mortality in rats and dogs…
  • 2020 American Transplant Congress

    In Vivo Phosphorylation of C-MET by ANG-3777, A Hepatocyte Growth Factor Mimetic

    L. Paka, I. D. Goldberg

    Angion Biomedica, Uniondale, NY

    *Purpose: : The biological effects of hepatocyte growth factor/scatter factor (HGF) and its mimetics are mediated by a signal cascade initiated by binding of HGF…
  • 2020 American Transplant Congress

    Stem Cell and Novel Neurotrophic Factors to Promote Functional Outcomes in Limb Transplantation

    S. K. Salgar, J. Weiss, C. Phillips, E. Malin, V. Gorantla, J. Harding

    Clinical Investigation, Madigan Army Medical Center, Tacoma, WA

    *Purpose: Recently, transplantation of hand and face has become a new clinical specialty. The objective of this study was to determine whether adult Mesenchymal Stem…
  • 2020 American Transplant Congress

    ANG-3777, A Hepatic Growth Factor Mimetic, Attenuates Mercuric Chloride-Induced Renal Dysfunction and Mortality in Rats

    P. Narayan, I. D. Goldberg

    Angion Biomedica, Uniondale, NY

    *Purpose: ANG-3777 is a small-molecule mimetic of hepatocyte growth factor (HGF). In vitro models have shown ANG-3777 to have protective effects in renal cell lines,…
  • 2020 American Transplant Congress

    Regulatory T Cell-Derived Amphiregulin Activates Fibroblasts to Promote Chronic Rejection after Heart Transplantation

    L. Fan1, X. Zhang1, T. Li1, L. R. Mathews1, G. K. Dwyer2, M. J. Calderon3, K. E. Helfrich3, M. A. Ross3, S. C. Watkins3, H. R. Turnquist1

    1Surgery, University of Pittsburgh, Pittsburgh, PA, 2Immunology, University of Pittsburgh, Pittsburgh, PA, 3Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Chronic rejection (CR) after organ transplantation (Tx) manifests as function-limiting allograft fibrosis and vasculopathy. Current immunosuppressants fail to prevent CR and insights into the…
  • 2020 American Transplant Congress

    The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor C-MET Signaling

    L. Paka, I. D. Goldberg

    Angion Biomedica, Uniondale, NY

    *Purpose: Hepatocyte growth factor (HGF) regulates cell growth, development and tissue repair. HGF activity is mediated by the c-MET signaling pathway. The biological effects of…
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