2017 American Transplant Congress
Immunoregulatory Roles of CD137 Signaling in Graft-versus-Host Disease.
CD137 functions mainly as a costimulatory molecule for T cell activation. However, its functions have been found in a variety of other immune and nonimmune…2017 American Transplant Congress
Depletion of T-Cells from G-CSF Mobilized Human PBMC Prevents Acute GVHD in NSG Mice.
Institute for Cellular Therapeutics, University of Louisville, Louisville, KY
Allogeneic HSC transplantation is commonly utilized for the treatment of hematologic malignancies and autoimmune diseases. However, allogeneic HSC transplantation is limited by potential for the…2017 American Transplant Congress
Graft-versus-Host Disease Following Deceased Donor Liver Transplant.
Henry Ford Hospital, Detroit, MI
We reviewed our institutional experience with graft-versus-host disease (GVHD) following orthotopic liver transplantation (OLT). All OLT from 10/1/2013-10/1/2016 were reviewed. Five cases of GVHD were…2017 American Transplant Congress
Eight Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients.
1Northwestern University, Chicago; 2U of Louisville, Louisville
36 subjects have been transplanted in a phase 2 protocol (IDE 13947) to induce tolerance in recipients of living donor renal allografts (KTx). The protocol…2017 American Transplant Congress
Dominant Role of Clonal Deletion in Achieving Immune Tolerance After Unrelated Cord Blood Transplantation.
The mechanism of immune tolerance after successful hematopoietic stem cell transplantation is not fully understood. Both central (clonal deletion) and peripheral (anergy, Treg, Tr1) mechanisms…2017 American Transplant Congress
Contemporary Outcomes and Risk Factors of Acute Graft-versus-Host Disease After Liver Transplant.
Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, MI
Introduction:Acute graft-versus-host-disease (GVHD) is a rare complication of orthotopic liver transplant (LT) that has an estimated incidence of 0.1%-2% per year. This complication of OLT…2017 American Transplant Congress
Macrophage Specific Deletion of RhoA Inhibits Fractalkine Signaling and Abrogates Chronic Rejection of Cardiac Allograft.
Surgery, Houston Methodist Hospital and Research Institute, Houston
Objective. Chronic rejection of transplanted organs remains unresolved issue in organ transplantation. The chronic rejection is the most common cause of graft loss within 10…2017 American Transplant Congress
Graft-versus-Host Disease in Intestine Transplantation.
Surgery, Indiana University School of Medicine, Indianapolis, IN
PurposeThis study reports the incidence, location, and outcomes of graft-versus-host disease (GVHD) at an active intestine transplant center. Subgroup analysis is employed to assess for…2017 American Transplant Congress
iNKT Cell Activation Plus Veto Cell Transfer Yields Complete Chimerism in a Murine Sub-Lethal Bone Marrow Transplant Model.
Transplant tolerance induction makes it possible to preserve functional grafts for a lifetime without immunosuppressants. We have previously established a novel method for mixed chimera…2017 American Transplant Congress
Immune Monitoring-Guided Treatment of a Pediatric Patient with Sequential GvHD, Acute Rejection and CMV Infection Following Lung Transplantation.
Background: A 17 year old patient with cystic fibrosis (HLA-A11+, CMV-) underwent bilateral sequential lung transplantation (donor: HLA-A32+, CMV+). Immunosuppression (IS) consisted of Tacrolimus, MMF…
American Transplant Congress abstracts