ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft-versus-host-disease"

  • 2019 American Transplant Congress

    In Vivo/In Situ Behaviour of Allogeneic Spleen versus Bone Marrow Cells in Wild-Type Neonatal Mice: Insights into Robust Transplant Tolerance Induction

    R. A. Bascom, K. Tao, L. J. West

    Pediatrics, University of Alberta, Edmonton, AB, Canada

    *Purpose: Comparing the behaviour of fully allogeneic spleen (SC) vs bone marrow cells (BMC) in non-conditioned neonatal mice is important for maximizing synergistic interactions between…
  • 2019 American Transplant Congress

    Superiority of Donor-Specifically vs. Polyclonally Expanded Regulatory T Cells in Controlling Graft Rejection in the NSG Mouse Human Skin Graft Model

    J. H. Voss1, F. Zheng1, M. D. Jendrisak2, J. R. Leventhal1, Z. J. Zhang1, J. M. Mathew1

    1Surgery – Comprehensive Transplant Center, Northwestern University, Chicago, IL, 2Gift of Hope Organ & Tissue Donor Network, Itasca, IL

    *Purpose: Naturally occurring CD4+CD25highFOXP3+ Regulatory T cells (Tregs) function as mediators of immune homeostasis. So, they are beginning to be utilized for controlling hyper-immunity and…
  • 2018 American Transplant Congress

    CD4+CD25bright Regulatory T Cells Prevent Acute Xenogeneic GVHD

    Y. Huang, A. Merchak, H. Xu, A. Chhabra, A. Khalil, Y. Wen, M. Binion, M. Badder, L. Kahn, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.

    Graft-versus-host disease (GVHD) is a major complication and limitation to the broad application of hematopoietic stem cell transplantation. Cell therapy has emerged as a promising…
  • 2018 American Transplant Congress

    Tipping the “Immune Balance” towards Tolerance by Specific and Systematic Depletion of Donor and Host Effector Cells

    R. Bascom, K. Tao, L. West.

    Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada.

    Purpose: To induce robust transplant tolerance in neonates with fully allogeneic spleen and bone marrow cells (SC/BMC) it is crucial to define the complex interplay…
  • 2018 American Transplant Congress

    Treatment Patterns and Burden among Chronic Graft versus Host Disease Patients on Second-Line Systemic Treatments Including Extracorporeal Photopheresis

    X. Huang,2 N. Joshi,1 L. Luo,1 G. Mitri,3 B. Lovelace,2 A. Pham,3 X. Gao.1

    1Pharmerit International, Bethesda, MD; 2Mallinckrodt Pharmaceuticals, Bedminster, NJ; 3Formerly of Mallinckrodt Pharmaceuticals, Bedminster, NJ.

    Extracorporeal Photopheresis (ECP) is a cell-based immunomodulatory therapeutic procedure reimbursable by the Centers for Medicare and Medicaid Services for patients with chronic Graft versus Host…
  • 2018 American Transplant Congress

    CD8+ Tissue Resident Memory T Cells Are Key Effector Cells in Intestinal Transplantation Patients with GvHD

    O. Aguirre, B. Houlihan, A. Karabala, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.

    Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.

    A. As the pathophysiologic role of Tissue Resident Memory T Cells (TRM) in intestinal transplantation (ITx) is unknown, this study aims to test the hypothesis…
  • 2018 American Transplant Congress

    Recipient Conditioning Results in IL-33 Support of Potent Th1 Alloimmune Responses after CD4+ T Cells Upregulate ST2 during Lymphopenia Induced Proliferation

    G. Dwyer,1 L. Mathews,1 A. Lucas,1 B. Blazar,2 H. Turnquist.1

    1Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Pediatrics, University of Minnesota, Minneapolis, MN.

    Purpose: IL-33 is typically associated with support of Th2 and Treg responses. Yet, recipient conditioning before allogeneic hematopoietic cell transplantation (alloHCT) releases IL-33 to promote…
  • 2018 American Transplant Congress

    Lactate/platelet Ratio after Liver Transplantation; a Novel Predictor for Short-Term Graft Failure

    K. Takahashi,1 S. Nagai,2 M. Safwan,2 K. Collins,2 M. Rizzari,2 A. Yoshida,2 N. Ohkohchi,1 M. Abouljoud.2

    1Surgery, University of Tsukuba, Tsukuba, Ibaraki, Japan; 2Transplant, Henry Ford Hospital, Detroit, MI.

    Background; Recently, platelet count and lactate level after liver transplantation (LT) have been both separately reported as predictors of graft failure. In this study, we…
  • 2018 American Transplant Congress

    M-CSF and TNF-α Induce Human MDSCs That Attenuate GVHD

    F. Han, C. Ding, Y. Zhao, P. Tian.

    Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

    Myeloid-derived suppressor cells (MDSCs) negatively regulate immune response and participate in the induction of prolonged allograft survival in animal models. Human MDSC therapy may be…
  • 2017 American Transplant Congress

    Eight Year Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients.

    J. Leventhal,1 J. Galvin,1 J. Mathew,1 L. Gallon,1 D. Stare,1 A. Sweeney,1 J. Miller,1 M. Abecassis,1 S. Ildstad.2

    1Northwestern University, Chicago; 2U of Louisville, Louisville

    36 subjects have been transplanted in a phase 2 protocol (IDE 13947) to induce tolerance in recipients of living donor renal allografts (KTx). The protocol…
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