ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Graft-versus-host-disease"

  • 2019 American Transplant Congress

    Comparison of Tacrolimus or Cyclosporine Combined with Methotrexate for Graft versus Host Disease Prophylaxis after Allogeneic Hematopoietic Cell Transplantation: A Meta-Analysis

    M. Chen, B. Huang, Y. Zhang, W. Ju, X. He

    Transplant Center, Sun Yat-sen University, Guangzhou, China

    *Purpose: After patients received hematopoietic stem cell transplantation (HSCT) ,both cyclosporine (CsA) and tacrolimus (TAC) in combination with methotrexate (MTX) have been recommended as standard…
  • 2019 American Transplant Congress

    Differential Diagnosis of Membranous Nephropathy Occurs after Bone Marrow Transplantation and Renal Transplantation

    L. Guo1, H. Wang1, Y. Tan2, J. Shen1, R. Wang1, J. Wu1, J. Chen1

    1Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China, 2First Affiliated Hospital of Zhejiang University, Hangzhou, China

    *Purpose: Membranous nephropathy (MN), considered as a rare autoimmune kidney disease, often occurs in synchronization with manifestation of chronic graft-versus-host disease after transplantation. After bone…
  • 2018 American Transplant Congress

    CD8+ Tissue Resident Memory T Cells Are Key Effector Cells in Intestinal Transplantation Patients with GvHD

    O. Aguirre, B. Houlihan, A. Karabala, R. Girlanda, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer.

    Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.

    A. As the pathophysiologic role of Tissue Resident Memory T Cells (TRM) in intestinal transplantation (ITx) is unknown, this study aims to test the hypothesis…
  • 2018 American Transplant Congress

    Recipient Conditioning Results in IL-33 Support of Potent Th1 Alloimmune Responses after CD4+ T Cells Upregulate ST2 during Lymphopenia Induced Proliferation

    G. Dwyer,1 L. Mathews,1 A. Lucas,1 B. Blazar,2 H. Turnquist.1

    1Starzl Transplantation Institute and Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA; 2Department of Pediatrics, University of Minnesota, Minneapolis, MN.

    Purpose: IL-33 is typically associated with support of Th2 and Treg responses. Yet, recipient conditioning before allogeneic hematopoietic cell transplantation (alloHCT) releases IL-33 to promote…
  • 2018 American Transplant Congress

    Lactate/platelet Ratio after Liver Transplantation; a Novel Predictor for Short-Term Graft Failure

    K. Takahashi,1 S. Nagai,2 M. Safwan,2 K. Collins,2 M. Rizzari,2 A. Yoshida,2 N. Ohkohchi,1 M. Abouljoud.2

    1Surgery, University of Tsukuba, Tsukuba, Ibaraki, Japan; 2Transplant, Henry Ford Hospital, Detroit, MI.

    Background; Recently, platelet count and lactate level after liver transplantation (LT) have been both separately reported as predictors of graft failure. In this study, we…
  • 2018 American Transplant Congress

    M-CSF and TNF-α Induce Human MDSCs That Attenuate GVHD

    F. Han, C. Ding, Y. Zhao, P. Tian.

    Department of Kidney Transplantation, Hospital of Nephropathy, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.

    Myeloid-derived suppressor cells (MDSCs) negatively regulate immune response and participate in the induction of prolonged allograft survival in animal models. Human MDSC therapy may be…
  • 2018 American Transplant Congress

    CD4+CD25bright Regulatory T Cells Prevent Acute Xenogeneic GVHD

    Y. Huang, A. Merchak, H. Xu, A. Chhabra, A. Khalil, Y. Wen, M. Binion, M. Badder, L. Kahn, S. Ildstad.

    Institute for Cellular Therapeutics, University of Louisville, Louisville, KY.

    Graft-versus-host disease (GVHD) is a major complication and limitation to the broad application of hematopoietic stem cell transplantation. Cell therapy has emerged as a promising…
  • 2018 American Transplant Congress

    Tipping the “Immune Balance” towards Tolerance by Specific and Systematic Depletion of Donor and Host Effector Cells

    R. Bascom, K. Tao, L. West.

    Alberta Transplant Institute, Canadian National Transplant Research Program, University of Alberta, Edmonton, Canada.

    Purpose: To induce robust transplant tolerance in neonates with fully allogeneic spleen and bone marrow cells (SC/BMC) it is crucial to define the complex interplay…
  • 2018 American Transplant Congress

    Treatment Patterns and Burden among Chronic Graft versus Host Disease Patients on Second-Line Systemic Treatments Including Extracorporeal Photopheresis

    X. Huang,2 N. Joshi,1 L. Luo,1 G. Mitri,3 B. Lovelace,2 A. Pham,3 X. Gao.1

    1Pharmerit International, Bethesda, MD; 2Mallinckrodt Pharmaceuticals, Bedminster, NJ; 3Formerly of Mallinckrodt Pharmaceuticals, Bedminster, NJ.

    Extracorporeal Photopheresis (ECP) is a cell-based immunomodulatory therapeutic procedure reimbursable by the Centers for Medicare and Medicaid Services for patients with chronic Graft versus Host…
  • 2017 American Transplant Congress

    A Novel Method for Detecting and Monitoring Chimerism in Patients with Graft versus Host Disease After Liver Transplantation.

    B. Peng, H. Liu, K. Cheng, Y. Zhao, X. She, Y. Niu, Q. Zhuang, Y. Ming.

    Transplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China; Engineering & Technology Research Center for Transplantation Medicine, National Ministry of Health, Changsha, Hunan, China

    Background Graft versus host disease (GVHD) after orthotopic liver transplantation (OLT) is a rare but lethal complication. Early diagnosis and treatment is critical for a…
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