ATC Abstracts

American Transplant Congress abstracts

  • Home
  • Meetings Archive
    • 2020 American Transplant Congress
    • 2019 American Transplant Congress
    • 2018 American Transplant Congress
    • 2017 American Transplant Congress
    • 2016 American Transplant Congress
    • 2015 American Transplant Congress
    • 2013 American Transplant Congress
  • Keyword Index
  • Resources
    • 2016 Resources
      • 2016 Welcome Letter
      • ATC 2016 Program Planning Committees
      • ASTS Council 2015-2016
      • AST Board of Directors 2015-2016
    • 2015 Resources
      • 2015 Welcome Letter
      • ATC 2015 Program Planning Committees
      • ASTS Council 2014-2015
      • AST Board of Directors 2014-2015
      • 2015 Conference Schedule
  • Advanced Search

Comparison of Tacrolimus or Cyclosporine Combined with Methotrexate for Graft versus Host Disease Prophylaxis after Allogeneic Hematopoietic Cell Transplantation: A Meta-Analysis

M. Chen, B. Huang, Y. Zhang, W. Ju, X. He

Transplant Center, Sun Yat-sen University, Guangzhou, China

Meeting: 2019 American Transplant Congress

Abstract number: C9

Keywords: Graft-versus-host-disease, Immunosuppression

Session Information

Date: Monday, June 3, 2019

Session Name: Poster Session C: Immunosuppression Preclinical Studies

Session Time: 6:00pm-7:00pm

 Presentation Time: 6:00pm-7:00pm

Location: Hall C & D

Related Abstracts
  • CNI-Related Renal Impairment in Liver Transplantation: A Comparison of Cyclosporine and Tacrolimus-Based Regimens
  • Outcomes of Hispanic Kidney Transplant Recipients Under a Cyclosporine Versus Tacrolimus Based Immunosuppression Regimen

*Purpose: After patients received hematopoietic stem cell transplantation (HSCT) ,both cyclosporine (CsA) and tacrolimus (TAC) in combination with methotrexate (MTX) have been recommended as standard prophylaxis strategy for GVHD by European Group of Blood and Marrow Transplantation (EBMT). However, the advantage of TAC combined with MTX lacks conclusive evidence.

*Methods: We searched online databases for studies on the comparsion of CsA+MTX and TAC+MTX on patients received HSCT. Odds ratio (OR) and 95% confidence interval (CI) was applied to compare the pooled data.

*Results: We found that there is a significant reduction of Grade II to IV aGVHD(OR 0.42; [CI], 0.28-0.61; p<0.00001), Grade III to IV aGVHD (OR 0.59; [CI], 0.38-0.92; p=0.02), chronic GVHD (OR 0.79; [CI], 0.62-1.00; p=0.05)and non-relapse mortality (OR 0.62; [CI], 0.40-0.95; p=0.03), and increased OS rate (only in those received from unrelated donor) (OR 1.30; [CI], 1.15-1.48; p<0.0001)in TAC+MTX group. And similar outcomes occurred in relapse rate and disease free survival rate in both groups.

*Conclusions: We conclude that TAC+MTX is superior to CsA+MTX on the prevention aGVHD in patients received HSCT, which further prolongs OS in some specific populations. Further studies are still required to evaluate effect of TAC or CsA combined with other suppressors in the therapy of HSCT.

  • Tweet
  • Email
  • Print

To cite this abstract in AMA style:

Chen M, Huang B, Zhang Y, Ju W, He X. Comparison of Tacrolimus or Cyclosporine Combined with Methotrexate for Graft versus Host Disease Prophylaxis after Allogeneic Hematopoietic Cell Transplantation: A Meta-Analysis [abstract]. Am J Transplant. 2019; 19 (suppl 3). https://atcmeetingabstracts.com/abstract/comparison-of-tacrolimus-or-cyclosporine-combined-with-methotrexate-for-graft-versus-host-disease-prophylaxis-after-allogeneic-hematopoietic-cell-transplantation-a-meta-analysis/. Accessed March 2, 2021.

« Back to 2019 American Transplant Congress

Most Viewed Abstracts

  • This Week
  • This Month
  • All Time
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes
  • Penis Transplantation: First U.S. Experience.
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Subtherapeutic Low Tacrolimus Trough Levels (≤3.5 Ng /ml) Are A Risk Factor For Acute Rejection And Creatinine Doubling.
  • Penis Transplantation: First U.S. Experience.
  • A Decade of Donor-Derived Disease: A Report of the OPTN Ad Hoc Disease Transmission Advisory Committee (DTAC).
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Penis Transplantation: First U.S. Experience.
  • Is There a Difference Between DCD and DBD Kidney Transplantation with Similar KDPI?
  • Low GFR after Kidney Donation Is Not Chronic Kidney Disease
  • Evidence of a Clinically Significant Drug-Drug Interaction between Cannabidiol and Tacrolimus: A Case Report
  • Kidney Dialysis after Heart Transplantation: The Short and Long Term Outcomes

Visit Our Partner Sites

American Transplant Congress (ATC)

Visit the official site for the American Transplant Congress »

American Journal of Transplantation

The official publication for the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS) »

American Society of Transplantation (AST)

An organization of more than 3000 professionals dedicated to advancing the field of transplantation. »

American Society of Transplant Surgeons (ASTS)

The society represents approximately 1,800 professionals dedicated to excellence in transplantation surgery. »

Copyright © 2013-2021 by American Society of Transplantation and the American Society of Transplant Surgeons. All rights reserved.

Privacy Policy

loading Cancel
Post was not sent - check your email addresses!
Email check failed, please try again
Sorry, your blog cannot share posts by email.
This site uses cookies: Find out more.