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Articles tagged "Graft survival"

  • 2016 American Transplant Congress

    Urinary Virome in Human Kidney Transplants Reveals Multiple Virus Subtypes with Distinct Genome Polymorphisms.

    R. Ranjan,1 A. Rani,1 H. McGee,1 D. Brennan,2 P. Finn,1 D. Perkins.1,3

    1Medicine, University of Illinois, Chicago, IL; 2Division of Renal Diseases, Washington University School of Medicine, St. Louis, MO; 3Surgery, University of Illinois, Chicago, IL.

    Recent studies have established that human urine has its own unique microbiome, but little is known about the virome. The human virome is the collection…
  • 2016 American Transplant Congress

    Fecal Microbiota Transplant Results in Durable Changes to Host Microbiota That Correlate with Allograft Outcome.

    C. Brinkman, L. Hittle, W. Fricke, E. Mongodin, J. Bromberg.

    CVID and IGS, University of Maryland School of Medicine, Baltimore, MD.

    Hypothesis: We previously presented highly significant differences in the bacterial community structures of human renal allograft recipients over time. Likewise, murine normal, colitic, and pregnant…
  • 2016 American Transplant Congress

    Machine Perfusion (MP) at 21[deg]C Simulates Hibernation Metabolic Pathways in a Non-Hibernator Mammal.

    B. Banan, S. Dobrowolski, G. Michalopoulos, P. Fontes.

    University of Pittsburgh, Pittsburgh.

    Background: Hibernation is a complex and multi stage process that leads to unique metabolic changes over an extended period of time. Regulatory genes and transcription…
  • 2016 American Transplant Congress

    The Oldest and Coldest in Kidney Paired Donation: Experience of the National Kidney Registry.

    N. Nassiri,1 L. Kwan,1 J. Sinacore,2 J. Veale.1

    1Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2National Kidney Registry, Babylon, NY.

    OBJECTIVES: To evaluate renal allograft efficacy and survivability in elderly donors and prolonged cold ischemia time (CIT).METHODS: 1,402 living donor kidney transplants from 02/2008-06/2015 recorded…
  • 2016 American Transplant Congress

    Evolving to Everolimus: A Safe and Effective Option for Pancreas Transplant.

    S. Yeager, A. Carlson, C. Truax, N. Kenyon, F. Ahmed, J. Corbett, F. Shihab, L. Smith.

    University of Utah Health Care, Salt Lake City, UT.

    Although everolimus is an attractive option for conversion therapy in pancreas tx pts that experience SE's of commonly used immunosuppression, TAC and MPA, there is…
  • 2016 American Transplant Congress

    Refill-Based Immunosuppression Non-Adherence Is Associated with Increased Death Censored Graft Loss.

    K. Wen, S. Gourishankar, S. Shojai, A. Wong, M. Bae, D. Grynoch, P. Halloran.

    Medicine, University of Alberta, Edmonton, AB, Canada.

    Introduction Medication non-adherence is a major contributor of graft loss in kidney transplant(KTX) recipients. We aim to evaluate the association of immunosuppression non-adherence to graft…
  • 2016 American Transplant Congress

    Heterologous Persistent and Latent Viral Infections Do Not Impact Graft Survival.

    J. Espinosa,1,2 M. McRae,1 J. Wang,1 A. Kirk.1

    1Duke University, Durham; 2Emory University, Atlanta.

    Purpose: Infection induces costimulation-resistant memory T cells with heterologous alloreactivity. Rapamycin has been shown to mitigate the effect of these cells in transplant rejection. Previous…
  • 2016 American Transplant Congress

    Prolonged Pre-Transplant Dialysis Duration Reverses the “Nephroprotective Effect” in Simultaneous Liver-Kidney Transplant Recipients.

    M. Casey, X. Wen, A. Santos, S. Rehman, K. Womer.

    University of Florida, Gainesville.

    Past literature has suggested that simultaneous liver-kidney(SLK) transplant recipients may experience a nephroprotective effect compared to kidney(Ki) alone transplant recipients. Since hepatorenal syndrome is a…
  • 2016 American Transplant Congress

    Clinical Significance of C3d Binding Donor Specific Anti-HLA Antibodies (DSA) Detected by Single Antigen Beads (SAB) After Kidney Transplantation.

    R. Pelletier,1 I. Balazs,2 P. Adams,3 P. Steller,3 N. DiPaola,4 L. Rankin,3 A. Diez,5 M. Henry.1

    1Surgery/Transplant, The Ohio State University Wexner Medical Center, Columbus, OH; 2Discovery Research, Immucor, Inc, Stamford, CT; 3Tissue Typing Laboratory, The Ohio State University Wexner Medical Center, Columbus, OH; 4Methodist Hospital, Houston, TX; 5Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH.

    A new Luminex-based SAB method detects DSA compliment fixing via C3d-binding. This study compares the clinical outcomes in kidney recipients that developed de novo DSA…
  • 2016 American Transplant Congress

    The Combined Effect of Acute Rejection and De Novo Donor-Specific Antibodies on Kidney Allograft Survival.

    S. Davis, J. Gralla, A. Wiseman, J. Cooper.

    Division of Renal Diseases and Hypertension, University of Colorado, Aurora, CO.

    While dnDSA is associated with graft loss in multiple studies, the clinical context in which dnDSA develops and contributes to graft loss is less well…
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