Articles tagged "Graft survival"

2016 American Transplant Congress
Normothermic Ex-Vivo Perfusion of the Intestine: The Introduction of an Innovative Physiologic Model with Novel Biomarkers.
B. Soliman, T. Okamoto, C. Quintini, Q. Liu, M. Fujiki, A. Khanna, K. Hashimoto, J. Fung, K. Abu-Elmagd.
General Surgery, Transplant Center, Cleveland Clinic Foundation, Cleveland, OH.
Purpose: Ischemia reperfusion injury is a major risk factor for short and long-term functional survival after intestinal transplantation. Normothermic machine perfusion is an emerging biotechnology…
2016 American Transplant Congress
Angiotensin II Type 1 Receptor Antibodies Are Associated with Allograft Loss in Pediatric Renal Transplantation.
M. Pearl,¹ Q. Zhang,² M. Palma Diaz,³ J. Grotts,⁴ J. Brook,⁴ D. Gjertson,² P. Weng,¹ E. Reed,² E. Tsai.¹
¹Pediatrics, University of California-Los Angeles, Los Angeles, CA; ²Pathology and Laboratory Medicine, University of California-Los Angeles, Los Angeles, CA; ³Anatomic & Clinical Pathology, University of California-Los Angeles, Los Angeles, CA; ⁴Biostatistics, University of California-Los Angeles, Los Angeles, CA.
Background: Angiotensin II type 1 receptor antibody (AT1R-Ab) is associated with vascular injury and allograft failure in adult kidney transplantation. Its role in pediatric transplantation…
2016 American Transplant Congress
Clinical Significance of Isolated v1 Arteritis in Renal Transplantation.
D. Mikhail,^1,3 J. Wei,³ D. Kleinsteuber,² M. Gabril,^2,3 A. Sener,^1,3 M. Moussa,^2,3 P. Luke.^1,3
¹Department of Surgery, Division of Urology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ²Department of Pathology and Laboratory Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ³Undergraduate Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada.
INTRO: The presence of intimal arteritis (v) in renal transplant biopsies (Bx) establishes Grade II-III AVR (Acute Vascular Rejection) according to the Banff Classification. The…
2016 American Transplant Congress
Assessing the Induction of Tolerance to Vascularized Composite Allotransplantation in Miniature Swine.
J. Walch, J. Alonso-Escalante, H. Wang, B. Oh, M. Iglesias, A. Lee, G. Brandacher, G. Raimondi.
Plastic and Reconstructive Surgery, Johns Hopkins Medical Institute, Baltimore, MD.
Purpose: Miniature swine is a pre-clinical large animal model well suited to validate protocols of tolerance induction to vascularized composite allotransplantation (VCA). However, tools to…
2016 American Transplant Congress
Cold Ischemia Induced Outcomes in Kidney Transplantation: A Meta-Analysis.
D. Bennett, M. Mustafa, M. Chiles, W. Skillen, S. Mohan.
Columbia University Medical Center, New York, NY.
Objective: To examine the association between cold ischemia time (CIT) and delayed graft function (DGF) and death-censored graft failure in kidney transplantation.Methods: To identify relevant…
2016 American Transplant Congress
Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allografts by Combination of Anti-BTLA mAb (6B2) and Anti-PD-1 mAb (PIM-2).
E. Yin,^1,2 M. Uchiyama,^1,3 X. Jin,^1,4 T. Shimokawa,³ H. Yagita,⁵ M. Niimi.¹
¹Surgery, Teikyo University, Tokyo, Japan; ²Cardiovascular Surgery, The 2nd Affiliated Hospital of Harbin Medical University, Harbin, China; ³Cardiovascular Surgery, Teikyo University, Tokyo, Japan; ⁴Thoracic Surgery, The 3rd Affiliated Hospital of Harbin Medical University, Harbin, China; ⁵Immunology, Juntendo University Hospital, Tokyo, Japan.
Background: The co-inhibitory receptor B and T lymphocyte attenuator (BTLA) and Programmed death (PD)-1 had been suggested to have immunomodulatory activity. This study investigated the…
2016 American Transplant Congress
Pediatric En Bloc Kidney Transplants Reduce DGF and Are Misrepresented by the KDPI.
M. Khan,¹ H. El-Hennawy,¹ A. Farney,¹ J. Rogers,¹ G. Orlando,¹ A. Reeves-Daniel,² A. Palanisamy,² M. Gautreaux,³ S. Iskandar,³ W. Doares,⁴ S. Kaczmorski,⁴ R. Stratta.¹
¹Surgery, Wake Forest, Winston-Salem, NC; ²Internal Medicine, Wake Forest, Winston-Salem, NC; ³Pathology, Wake Forest, Winston-Salem, NC; ⁴Pharmacy, Wake Forest, Winston-Salem, NC.
Controversy exists regarding optimal use of kidneys from small pediatric donors (SPDs). The study purpose was to compare outcomes between single and dual en bloc…
2016 American Transplant Congress
Hydrogen Sulfide Treatment Mitigates Donor Tissue Necrosis During Prolonged Cold Storage and Improves Survival Following Allogeneic Renal Transplantation.
I. Lobb,^1,3 W. Liu,² J. Jiang,³ D. Lian,³ A. Sener.^1,3,4
¹Microbiology and Immunology, Western University Canada, London, ON, Canada; ²Pathology, Western University Canada, London, ON, Canada; ³Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, ON, Canada; ⁴Surgery, Western University Canada, London, ON, Canada.
Organ procurement is inherently associated with ischemia-reperfusion injury (IRI), resulting from loss and subsequent restoration of blood flow, which is detrimental to short- and long-term…
2016 American Transplant Congress
Human Multipotent Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact.
E. Montanari,¹ R. Meier,² D. Bosco,¹ R. Mahou,³ P. Morel,² J. Seebach,⁴ C. Wandrey,³ C. Gonelle-Gispert,¹ L. Bühler.²
¹University of Geneva, Geneva, Switzerland; ²Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; ³Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; ⁴Division of Immunology and Allergy, University Hospitals of Geneva, Geneva, Switzerland.
Background: MSC exhibit immunomodulatory and anti-inflammatory properties. Notably, MSC were shown to preserve human islet function and to prevent cytokine-induced apoptosis. Aim: To evaluate the…
2016 American Transplant Congress
Outcomes of Isolated Pediatric Small Intestine Transplants Using Vascular Homografts.
Y. Kwon, N. Llore, R. Girlanda, K. Etesami, C. Desai, C. Matsumoto, T. Fishbein.
MedStar Georgetown Transplant Institute, MedStar Georgetown University Hospital, Washington, DC.
Background/aim: Pediatric intestinal transplantation has changed recently with more isolated small intestine transplants being performed in small children instead of combined liver-intestine transplants. Consequently, surgical…