Articles tagged "Graft survival"

2017 American Transplant Congress
Use of Pulsatile Perfusion Modifies the Effect of Delayed Graft Function on Graft Failure.
A. Thomas, A. Shaffer, A. Massie, D. Segev.
JHU, Baltimore
While the causal mechanisms remain elusive, delayed graft function (DGF) has been associated with graft failure in recipients of deceased-donor kidneys. Pulsatile perfusion pump use…
2017 American Transplant Congress
Blocked of Bat3 Expression Promotes Transplant Tolerance by Inducing IL-10 Expression in Dendritic Cells.
G. Gu, H. Hang, Q. Xia.
Department of Hepatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
Objective: To explore the effect of Bat3 on DCs during transplant tolerance induction.Methods: Allogeneic heart transplants were performed between WT and Bat3flox/floxCD11c-Cre+ mice, to test…
2017 American Transplant Congress
Pediatric Recipients of Deceased Adult Donor Kidneys Have Equivalent Outcomes Compared with Pediatric Donors.
D. Mikhail,¹ H. Sharma,^3,4 J. Chen,² M. Cooper,⁴ A. Sener,^1,3 P. Luke.^1,3
¹Urology, Western University, London, ON, Canada; ²Schulich School of Medicine and Dentistry, Western University, London, ON, Canada; ³Multi-Organ Transplant Surgery, Western University, London, ON, Canada; ⁴Transplant Surgery, Georgetown University, Washington, DC
INTRODUCTION:Efforts are made to transplant paediatric deceased donor kidneys into pediatric recipients. To our knowledge, data does not support better graft outcomes with matched pediatric…
2017 American Transplant Congress
Role of Donor-Derived Tissue Resident Memory T cells in Modulating Alloimmunity.
R. Crepeau, D. Liu, M. Ford.
Emory Transplant Center, Emory University, Atlanta, GA
Recipient-derived, graft-specific memory T cells play a critical role in mediating allograft rejection, particularly in the setting of immunosuppression with costimulation blockade. Recently, it is…
2017 American Transplant Congress
Assessment of Islet Damage During Isolation Utilizing miRNAs and Its Significance with Post-Transplant Outcome in TPIAT.
P. Saravanan,¹ M. Kanak,² G. Yoshimatsu,¹ M. Lawrence,¹ B. Naziruddin.³
¹Baylor Scott and White Research Institute, Dallas, TX; ²Virginia Commonwealth University, Richmond, VA; ³Baylor Simmons Transplant Institute, Dallas, TX
Background: Pancreatic islets with high quality are essential for better endocrine function and post-transplant outcome in total pancreatectomy with islet autotransplantation (TPIAT). The islets are…
2017 American Transplant Congress
Outcomes of Organs Transplants When the Donor Is a Prior Recipient.
G. Lee,¹ D. Goldberg,² M. Levine,¹ P. Abt.¹
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Medicine, University of Pennsylvania, Philadelphia, PA
Introduction: Organ scarcity continues to limit the field of transplantation, which leads to death for patients on waiting lists. Organs from “Organ Donors After Transplant”…
2017 American Transplant Congress
CXCL12 Modulation of Localized Immune Responses to Subcutaneous Islet Macrocapsulation.
M. Penson, M. Sremac, R. Sirbulescu, T. Brauns, F. Harrington, M. Poznansky.
Infectious Disease, Massachusetts General Hospital, Boston, MA
Purpose:To determine the impact of CXCL12 on vascularization and immune response to xeno islets transplanted into TheraCyte macroencapsulation device in diabetic C57BL/6 mice.Materials and Methods:Three…
2017 American Transplant Congress
The Feared Five Fungal Infections in Kidney Transplant Recipients: 20-Year Experience at a Midwestern Center.
S. Parajuli, A. Wick, S. Pandeya, B. Astor, J. Smith, A. Djamali, D. Mandelbrot.
University of Wisconsin, Madison, WI
Invasive fungal infections (IFI) are increasing in kidney transplant recipients (KTR). Here we present our experience with five feared IFIs in KTR transplanted between 01/01/1994…
2017 American Transplant Congress
Two Promoter Polymorphisms in the Genes Encoding for Complement Regulating Proteins CD46 and CD59 in Kidney Donors Are Associated with Biopsy Proven Acute Rejection.
L. Michielsen,¹ A. van Zuilen,¹ T. Kardol-Hoefnagel,² M. Verhaar,¹ H. Otten.²
¹Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, Netherlands; ²Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, Netherlands
BackgroundComplement regulating proteins, including CD46, CD55 and CD59, protect cells against self-damage. Because of their expression on the donor endothelium, they are hypothesized to be…
2017 American Transplant Congress
Prolonged Cold Ischemia Time as a Risk for Low Regeneration at the Early Phase After Living Donor Liver Transplantation.
K. Takahashi,^1,2 S. Nagai,¹ M. Safwan,¹ K. Putchakayala,¹ M. Rizzari,¹ K. Collins,¹ A. Yoshida,¹ G. Schnickel,¹ M. Abouljoud.¹
¹Transplant and Hepatobiliary Surgery, Henry Ford Hospital, Detroit, MI; ²Surgery, University of Tsukuba, Tsukuba, Ibaraki, Japan
Background. The objective of this study was to determine the risk factors for low liver regeneration at the early phase after living donor liver transplantation…