Articles tagged "Graft survival"

2017 American Transplant Congress
Correlation of Complement Activating Donor Specific Antibodies as Measured by C3d and Cross-Match Status.
A. Babu,^1,2,3 N. Krishnan,² D. Briggs,³ D. Mitchell,¹ S. Daga.^1,2,4
¹Warwick Medical School, University of Warwick, Coventry, United Kingdom; ²Nephrology and Transplantation, University Hospitals Coventrya and Warwickshire, Coventry, United Kingdom; ³Histocompatibility and Immunogenetics, NHS Blood and Transfusion, Birmingham, United Kingdom; ⁴Nephrology and Transplantation, Leeds Teaching Hospitals NHS Trust, Leeds, United Kingdom
Introduction. Complement dependent cytotoxicity, first described in 1969 is the only functional assay studying complement activation. C3d assay is developed recently to study complement activation…
2017 American Transplant Congress
Beta Cell-Specific Free Circulating DNA May Predict the Outcome After Clinical Islet Transplantation.
B. Gala-Lopez,¹ D. Neiman,² T. Kin,¹ D. O'Gorman,¹ A. Pepper,¹ A. Malcolm,¹ B. Glaser,³ R. Shemer,² Y. Dor,² J. Shapiro.¹
¹Department of Surgery, Clinical Islet Transplant Program, University of Alberta, Edmonton, AB, Canada; ²Department of Developmental Biology and Cancer Research, The Hebrew University-Hadassah Medical School, Jerusalem, Israel; ³Endocrinology and Metabolism Service, Department of Internal Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Optimizing engraftment and early survival of human beta cells after clinical islet transplantation is critical to long-term function, but there are no reliable, quantifiable measures…
2017 American Transplant Congress
Obesity Is an Important Factor in Deceased but Not Living Donor Kidney Transplants.
A. Asderakis, A. Ilham, U. Khalid, R. Chavez.
Cardiff Transplant Unit, University Hospital of Wales, Cardiff, United Kingdom
Introduction There is an increasing obesity among potential kidney transplant recipients. We had in the past shown that obesity did increase the wound infection rate,…
2017 American Transplant Congress
Metabolomics Study for Identification of Potential Biomarkers of Long-Term Survival in Kidney Transplantation Recipients.
C.-D. Kim, H.-Y. Jung, R.-H. Kim, S.-M. Park, J.-H. Park, K.-H. Lee, E.-S. Lee, K.-Y. Kim, J.-Y. Choi, J.-H. Cho, S.-H. Park, Y.-L. Kim.
Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea
Background: The development of new strategies to improve long-term survival outcome after kidney transplantation is also becoming important. Although current diagnosis of allograft dysfunction relies…
2017 American Transplant Congress
The Benefits of Pancreas After Kidney (PAK) Transplantation.
M. Curry,¹ J. Odorico,² J. Fridell.³
¹Research, UNOs, Richmond, VA; ²Department of Surgery, University of Wisconsin, Madison, WI; ³Department of Surgery, Indiana University, Indianpolis, IN
Background: PAK transplantation has been perceived as inferior to Simultaneous Pancreas and Kidney (SPK) transplantation with respect to patient and pancreas (PA) allograft survival. However,…
2017 American Transplant Congress
A Multidimensional Prognostic Score and Nomogram to Predict Kidney Transplant Survival: The Integrative Box (iBox) System.
A. Loupy,¹ O. Aubert,¹ B. Orandi,² A. Jackson,² M. Naesens,³ N. Kamar,¹ O. Thaunat,¹ E. Morelon,¹ M. Delahousse,¹ D. Viglietti,¹ D. Glotz,¹ C. Legendre,¹ X. Jouven,¹ R. Montgomery,² M. Stegall,⁴ D. Segev,² C. Lefaucheur.¹
¹Paris Translational Research Center for Organ Transplantation, Paris, France; ²Johns-Hopkins, Baltimore; ³Leuven University, Leuven, Belgium; ⁴Mayo Clinic, Rochester
The transplant field currently lacks of robust risk stratification models leading to major problems for clinical care, clinical trials, and medical progress. The goal of…
2017 American Transplant Congress
Early Detection of Xenograft Rejection or Injury by Donor Derived Cell Free DNA in Pig to Baboon Cardiac Xenotransplantation.
A. Singh,¹ S. Agbor-Enoh,² J. Chan,¹ S. Groham,² P. Corcoran,¹ B. Lewis,³ M. Thomas,³ D. Ayares,⁴ K. Horvath,¹ H. Valantine,² M. Mohiuddin.¹
¹CSRP, NHLBI/NIH, Bethesda, MD; ²LTG, NHLBI/NIH, Bethesda, MD; ³ORS/NIH, Bethesda, MD; ⁴Revivicor, Inc, Blacksburg, VA
Detection of early graft rejection (EGR) is a great deal in the field of transplantation (Tx). A number of biomarkers have been used to determine…
2017 American Transplant Congress
Can Pre-Treatment CDC Titres Predict Graft Outcomes in HLA Incompatible Transplants?
A. Prasad,¹ A. Yuvaraj,¹ D. Briggs,² N. Krishnan.¹
¹Renal Transplant, University Hospitals Coventry and Warwickshire, Coventry, United Kingdom; ²NHSBT, Birmingham, United Kingdom
Introduction: Complement Dependent Cytotoxic (CDC) (non-augmented) cross matching and Flow cytometric (FC) cross matching are two commonly used techniques to identify anti- Human Leucocyte Antigen…
2017 American Transplant Congress
Identification of NKG2D as Senescence Marker in Zero-Hour Kidney Biopsies Is Indicative for Clinical Outcome.
T. Resch,¹ J. Günther,¹ H. Hackl,² A. Sattler,³ S. Ebner,¹ P. Ritschl,³ M. Biebl,³ R. Öllinger,³ S. Schneeberger,¹ G. Brandacher,⁴ H. Schwelberger,¹ B. Zelger,⁵ D. Stauch,³ A. Pascher,³ J. Pratschke,³ K. Kotsch.³
¹Center of Operative Medicine, Department for Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria; ²Division of Bioinformatics, Biocenter, Medical University of Innsbruck, Innsbruck, Austria; ³Department for General, Visceral and Transplantation Surgery, Charité-Universitätsmedizin Berlin, Berlin, Germany; ⁴Department of Plastic and Reconstructive Surgery, Vascularized Composite Allotransplantation Laboratory, John Hopkins University School of Medicine, Baltimore; ⁵Institute of Pathology, Medical University of Innsbruck, Innsbruck, Austria
The definition of biological donor organ age rather than chronological age seems an obvious factor for the establishment of valid pre-transplant risk assessment. We therefore…
2017 American Transplant Congress
A Novel Microsurgical Penis Transplant Model to Study Distinct Immunologic Features of Urogenital Tissues.
G. Furtmüller, S. Fidder, B. Simons, B. Oh, B. Kern, D. Lough, M. Chicco, C. Brayton, W. Lee, D. Cooney, R. Redett, G. Brandacher.
Johns Hopkins University, Baltimore, MD
Background: Penis transplantation has been successfully employed in the recent past and represents an exciting avenue for restoration of male urogenitalia and function by using…