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Articles tagged "Graft survival"

  • 2017 American Transplant Congress

    Inferior Graft and Patient Survival After Living Donor Renal Transplantation of Negatively Selected Right Kidneys.

    S. Yamanaga,1,2,3 A. Posselt,1 C. Freise,1 C. Niemann,1 A. Rosario,1 D. Fernandez,1 T. Kobayashi,3 A. Ahearn,4 M. Tavakol,1 S.-M. Kang.1

    1Department of Surgery, UCSF, San Francisco, CA; 2Department of General Surgery, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan; 3Department of Renal Transplant Surgery, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan; 4Department of Transplant Surgery, UMass Memorial Medical Center, Worcester, MA

    Purpose: In living donor renal transplantation, the left kidney is usually chosen for anatomical reasons. The right kidney is sometimes chosen if it is believed…
  • 2017 American Transplant Congress

    Transplant Center Variability in Disparities for African-American Kidney Transplant Recipients.

    D. Taber, M. Gebregziabher, L. Egede, P. Baliga.

    MUSC, Charleston, SC

    Disparities research has traditionally focused on patient-level variables to ascertain predominant risk factors driving differences in outcomes for African-American (AA) kidney transplant (KTX) recipients. The…
  • 2017 American Transplant Congress

    iNKT Cell Activation Plus Veto Cell Transfer Yields Complete Chimerism in a Murine Sub-Lethal Bone Marrow Transplant Model.

    R. Ishii,1 T. Hirai,1 Y. Ishii,2 M. Okumi,1 K. Tanabe.1

    1Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; 2Cluster for Industry Partnerships (CIP), RIKEN, Yokohama, Japan

    Transplant tolerance induction makes it possible to preserve functional grafts for a lifetime without immunosuppressants. We have previously established a novel method for mixed chimera…
  • 2017 American Transplant Congress

    Dexamethasone Prolongs Cardiac Allograft Survival in a Murine Model Through Myeloid-Derived Suppressor Cells.

    T. Nakao,1 T. Nakamura,1 K. Masuda,1 T. Matsuyama,1 H. Ushigome,1 E. Ashihara,2 N. Yoshimura.1

    1Organ Transplantation and Regenerative Surgery, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2Clinical and Translational Physiology, Kyoto Pharmaceutical University, Kyoto, Japan

    Recently, myeloid-derived suppressor cells (MDSCs) have attracted considerable attention because of their cancer-promoting and immunosuppressive effects. The glucocorticoid (GC) dexamethasone (Dex) is an important immunosuppressive…
  • 2017 American Transplant Congress

    Recipient iNOS Deficiency Reduces Spontaneous Kidney Allograft Acceptance by Accelerating Allograft Loss.

    I. Aljabban, B. Jiang, C. Yang, D. Ndishabandi, R. White, P. Russell, J. Madsen, R. Colvin, A. Alessandrini.

    Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA

    Nitric oxide (NO) production by inducible nitric oxide synthase (iNOS), encoded by NOS2, is a hallmark of the innate immune axis, and is typically associated…
  • 2017 American Transplant Congress

    Effect of Initial Hepatic Arterial Followed by Portal Reperfusion on Outcomes After Liver Transplantation.

    R. Shahbazov,1 F. Azari,2 J. Alejo,2 M. Talanian,2 M. Fox,2 K. Kennedy,2 S. Kessel,2 A. Nickkholgh,1 D. Maluf,1 S. Pelletier.1

    1Department of Surgery, University of Virginia Medical Center, Charlottesville, VA; 2University of Virginia School of Medicine, Charlottesville, VA

    Background: While initial portal reperfusion (PV) of a liver allograft is nearly standardized, limited data suggests initial hepatic arterial reperfusion (HA) may improve hemodynamics and…
  • 2017 American Transplant Congress

    Three Induction Therapies on Patients with Delayed Graft Function After Kidney Transplantation, a Three-Year Outcome Analysis.

    A. Umber, M. Killackey, A. Paramesh, B. Alper, F. Teran, A. Baudy, Y. Liu, J. Buell, R. Zhang.

    Departments of Medicine and Surgery, Tulane University School of Medicine, New Orleans, LA

    We compare the 3-year outcomes of induction therapies with either methylprednisolone (group 1, n=58), basiliximab (group 2, n=56) or alemtuzumab (group 3, n=98) in primary…
  • 2017 American Transplant Congress

    A Composite Score Associated with Spontaneous Operational Tolerance in Kidney Transplant Recipients.

    R. Danger,1 M. Chesneau,1 C. Paul,1 P. Guérif,1 M. Durand,1 K. Newell,2 S. Kanaparthi,3 L. Turka,4 J.-P. Soulillou,1 R. Houlgatte,5 M. Giral,1,6 G. Ramstein,7 S. Brouard.1,6

    1Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; 2Department of Surgery, Emory University, Atlanta, GA; 3Immune Tolerance Network, Bethesda, MD; 4Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 5INSERM UMR 954,CHU de Nancy, DRCI, Nancy, France; 6CIC Biotherapy, CHU Nantes, Nantes, France; 7LINA DUKe, UMR 6241, Université de Nantes, Ecole des Mines de Nantes & CNRS, Nantes, France

    New challenges in renal transplantation include using biological information to devise a useful clinical test for discerning high- and low-risk patients for individual therapy and…
  • 2017 American Transplant Congress

    Donor Creatinine and Graft Outcomes in Pediatric Kidney Transplant Recipients.

    N. Hayde, M. Del Rio.

    Montefiore Medical Center, Bronx, NY

    Background: The role of donor peak and terminal creatinine on short and long term allograft outcomes in pediatric kidney transplant recipients is unclear.Aim: To determine…
  • 2017 American Transplant Congress

    Regulation of T Cell Migration by Specifically Targeting Lymphotoxin β Receptor (LTβR)-Mediated Non-Canonical NFkB Signaling.

    W. Piao, Y. Xiong, C. Brinkman, J. Bromberg.

    UMB, Baltimore

    Background:Selective recruitment of regulatory T cells (Treg) to draining lymph nodes is crucial for graft survival, and LTαβ-LTβR signaling is required to direct Treg into…
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